CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer LM McLane, MS Abdel-Hakeem, EJ Wherry Annual Review of Immunology 37, 2019 | 1385 | 2019 |
Developmental relationships of four exhausted CD8+ T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms JC Beltra, S Manne, MS Abdel-Hakeem, M Kurachi, JR Giles, Z Chen, ... Immunity 52 (5), 825-841. e8, 2020 | 581 | 2020 |
Early Interferon Therapy for Hepatitis C Virus Infection Rescues Polyfunctional, Long-Lived CD8+ Memory T Cells G Badr, N Bédard, MS Abdel-Hakeem, L Trautmann, B Willems, ... Journal of virology 82 (20), 10017-10031, 2008 | 167 | 2008 |
Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation. MS Abdel-Hakeem, S Manne, JC Beltra, E Stelekati, Z Chen, K Nzingha, ... Nature Immunology 22, 1008-1019, 2021 | 138 | 2021 |
Protective immunity against hepatitis C: many shades of gray MS Abdel-Hakeem, NH Shoukry Frontiers in immunology 5, 96299, 2014 | 124 | 2014 |
In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer SJ Chen Z, Arai E, Khan O, Zhang Z, Ngiow SF, He Y, Huang H, Manne S, Cao Z ... Cell 184 (5), 1262-1280, 2021 | 114 | 2021 |
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics JR Giles, SF Ngiow, S Manne, AE Baxter, O Khan, P Wang, R Staupe, ... Nature immunology 23 (11), 1600-1613, 2022 | 76 | 2022 |
Comparison of immune restoration in early versus late alpha interferon therapy against hepatitis C virus MS Abdel-Hakeem, N Bédard, G Badr, M Ostrowski, RP Sékaly, ... Journal of virology 84 (19), 10429-10435, 2010 | 68 | 2010 |
Signatures of protective memory immune responses during hepatitis C virus reinfection MS Abdel-Hakeem, N Bédard, D Murphy, J Bruneau, NH Shoukry Gastroenterology 147 (4), 870-881. e8, 2014 | 67 | 2014 |
Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage JB Johnnidis, Y Muroyama, SF Ngiow, Z Chen, S Manne, Z Cai, S Song, ... Science Immunology 6 (55), 2021 | 64 | 2021 |
HCV RNA Activates APCs via TLR7/TLR8 While Virus Selectively Stimulates Macrophages Without Inducing Antiviral Responses. YW Zhang, M El-Far, FP Dupuy, MS Abdel-Hakeem, Z He, FA Procopio, ... Scientific Reports 6, 2016 | 60 | 2016 |
The long noncoding RNA Morrbid regulates CD8 T cells in response to viral infection JJ Kotzin, F Iseka, J Wright, MB Basavappa, ML Clark, MA Ali, ... PNAS, 2019 | 52 | 2019 |
Signaling through FcγRIIA and the C5a-C5aR pathway mediate platelet hyperactivation in COVID-19 SA Apostolidis, A Sarkar, HM Giannini, RR Goel, D Mathew, A Suzuki, ... Frontiers in immunology 13, 834988, 2022 | 46 | 2022 |
Selective expansion of high functional avidity memory CD8 T cell clonotypes during hepatitis C virus reinfection and clearance MS Abdel Hakeem, M Boisvert, J Bruneau, H Soudeyns, NH Shoukry PLOS Pathogen 13 (2), e1006191, 2017 | 42 | 2017 |
Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries MS Abdel-Hakeem Viruses 11 (2), 2019 | 33 | 2019 |
Glycogen synthase kinase 3β inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolism MA Sarhan, MS Abdel-Hakeem, AL Mason, DL Tyrrell, M Houghton Scientific Reports 7 (1), 2495, 2017 | 33 | 2017 |
The hedgehog pathway suppresses neuropathogenesis in CD4 T cell-driven inflammation N Benallegue, H Kebir, R Kapoor, A Crockett, C Li, L Cheslow, ... Brain 144 (6), 1670-1683, 2021 | 19 | 2021 |
Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state JC Beltra, MS Abdel-Hakeem, S Manne, Z Zhang, H Huang, M Kurachi, ... BioRxiv, 2022.10. 03.509766, 2022 | 12 | 2022 |
Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure JC Beltra, MS Abdel-Hakeem, S Manne, Z Zhang, H Huang, M Kurachi, ... Immunity 56 (12), 2699-2718. e11, 2023 | 11 | 2023 |
The 7th Canadian Symposium on hepatitis C virus:“Toward elimination of HCV: how to get there” ML Cheng, MS Abdel-Hakeem, SE Cousineau, J Grebely, AD Marshall, ... Canadian Liver Journal, 139-152, 2018 | 9 | 2018 |