John Silke
John Silke
Professor, The Walter and Eliza Hall Institute
Verified email at - Homepage
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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
L Galluzzi, I Vitale, SA Aaronson, JM Abrams, D Adam, P Agostinis, ...
Cell Death & Differentiation 25 (3), 486-541, 2018
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
AM Verhagen, PG Ekert, M Pakusch, J Silke, LM Connolly, GE Reid, ...
cell 102 (1), 43-53, 2000
IAP antagonists target cIAP1 to induce TNFα-dependent apoptosis
JE Vince, WWL Wong, N Khan, R Feltham, D Chau, AU Ahmed, ...
Cell 131 (4), 682-693, 2007
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
L Zender, MS Spector, W Xue, P Flemming, C Cordon-Cardo, J Silke, ...
Cell 125 (7), 1253-1267, 2006
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism
JM Murphy, PE Czabotar, JM Hildebrand, IS Lucet, JG Zhang, ...
Immunity 39 (3), 443-453, 2013
Linear ubiquitination prevents inflammation and regulates immune signalling
B Gerlach, SM Cordier, AC Schmukle, CH Emmerich, E Rieser, TL Haas, ...
Nature 471 (7340), 591-596, 2011
Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
TL Haas, CH Emmerich, B Gerlach, AC Schmukle, SM Cordier, E Rieser, ...
Molecular cell 36 (5), 831-844, 2009
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins
AM Verhagen, J Silke, PG Ekert, M Pakusch, H Kaufmann, LM Connolly, ...
Journal of Biological Chemistry 277 (1), 445-454, 2002
IAPs, RINGs and ubiquitylation
DL Vaux, J Silke
Nature reviews Molecular cell biology 6 (4), 287-297, 2005
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
VS Marsden, L O'Connor, LA O'Reilly, J Silke, D Metcalf, PG Ekert, ...
Nature 419 (6907), 634-637, 2002
Caspase inhibitors
PG Ekert, J Silke, DL Vaux
Cell Death & Differentiation 6 (11), 1081-1086, 1999
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
KE Lawlor, N Khan, A Mildenhall, M Gerlic, BA Croker, AA D’Cruz, C Hall, ...
Nature communications 6 (1), 6282, 2015
RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis
JA Rickard, JA O’Donnell, JM Evans, N Lalaoui, AR Poh, TW Rogers, ...
Cell 157 (5), 1175-1188, 2014
XIAP discriminates between type I and type II FAS-induced apoptosis
PJ Jost, S Grabow, D Gray, MD McKenzie, U Nachbur, DCS Huang, ...
Nature 460 (7258), 1035-1039, 2009
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
JM Hildebrand, MC Tanzer, IS Lucet, SN Young, SK Spall, P Sharma, ...
Proceedings of the National Academy of Sciences 111 (42), 15072-15077, 2014
Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation
JE Vince, WWL Wong, I Gentle, KE Lawlor, R Allam, L O'Reilly, K Mason, ...
Immunity 36 (2), 215-227, 2012
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
V Sagulenko, SJ Thygesen, DP Sester, A Idris, JA Cridland, PR Vajjhala, ...
Cell Death & Differentiation 20 (9), 1149-1160, 2013
The diverse role of RIP kinases in necroptosis and inflammation
J Silke, JA Rickard, M Gerlic
Nature immunology 16 (7), 689-697, 2015
The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity
RB Damgaard, U Nachbur, M Yabal, WWL Wong, BK Fiil, M Kastirr, ...
Molecular cell 46 (6), 746-758, 2012
The Drosophila caspase DRONC is regulated by DIAP1
P Meier, J Silke, SJ Leevers, GI Evan
The EMBO journal 19 (4), 598-611, 2000
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