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michele perni
michele perni
Verified email at cam.ac.uk
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Year
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
G Fusco, SW Chen, PTF Williamson, R Cascella, M Perni, JA Jarvis, ...
Science 358 (6369), 1440-1443, 2017
3952017
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ...
Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017
2292017
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease
J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, ...
Science advances 2 (2), e1501244, 2016
1752016
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease
J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, ...
Proceedings of the National Academy of Sciences 114 (2), E200-E208, 2017
1722017
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, ...
Science advances 3 (6), e1700488, 2017
1052017
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, ...
Nature communications 10 (1), 1-13, 2019
962019
TDP-43 inclusion bodies formed in bacteria are structurally amorphous, non-amyloid and inherently toxic to neuroblastoma cells
C Capitini, S Conti, M Perni, F Guidi, R Cascella, A De Poli, A Penco, ...
PloS one 9 (1), e86720, 2014
672014
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine
M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, ...
ACS chemical biology 13 (8), 2308-2319, 2018
662018
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery
M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, ...
Journal of neuroscience methods 306, 57-67, 2018
452018
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
GT Heller, FA Aprile, TCT Michaels, R Limbocker, M Perni, FS Ruggeri, ...
Science advances 6 (45), eabb5924, 2020
372020
Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions
B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, ...
ACS chemical neuroscience 9 (12), 2959-2971, 2018
362018
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism
R Limbocker, B Mannini, FS Ruggeri, R Cascella, CK Xu, M Perni, S Chia, ...
Communications biology 3 (1), 1-10, 2020
332020
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers
FA Aprile, P Sormanni, M Podpolny, S Chhangur, LM Needham, ...
Proceedings of the National Academy of Sciences 117 (24), 13509-13518, 2020
332020
Probing the origin of the toxicity of oligomeric aggregates of α-synuclein with antibodies
R Cascella, M Perni, SW Chen, G Fusco, C Cecchi, M Vendruscolo, ...
ACS Chemical Biology 14 (6), 1352-1362, 2019
282019
Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans
RF Laine, T Sinnige, KY Ma, AJ Haack, C Poudel, P Gaida, N Curry, ...
ACS chemical biology 14 (7), 1628-1636, 2019
232019
Delivery of native proteins into C. elegans using a transduction protocol based on lipid vesicles
M Perni, FA Aprile, S Casford, B Mannini, P Sormanni, CM Dobson, ...
Scientific reports 7 (1), 1-8, 2017
152017
Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins
U Nowicka, P Chroscicki, K Stroobants, M Sladowska, M Turek, ...
Elife 10, 2021
132021
Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation
DC Delivoria, S Chia, J Habchi, M Perni, I Matis, N Papaevgeniou, ...
Science advances 5 (10), eaax5108, 2019
132019
Enhancement of the anti-aggregation activity of a molecular chaperone using a rationally designed post-translational modification
PR Lindstedt, FA Aprile, MJ Matos, M Perni, JB Bertoldo, B Bernardim, ...
ACS central science 5 (8), 1417-1424, 2019
132019
Squalamine and its derivatives modulate the aggregation of amyloid-β and α-synuclein and suppress the toxicity of their oligomers
R Limbocker, R Staats, S Chia, FS Ruggeri, B Mannini, CK Xu, M Perni, ...
Frontiers in neuroscience, 541, 2021
122021
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