| The CamSol method of rational design of protein mutants with enhanced solubility P Sormanni, FA Aprile, M Vendruscolo Journal of molecular biology 427 (2), 478-490, 2015 | 312 | 2015 |
| A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ... Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017 | 244 | 2017 |
| MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins D Piovesan, F Tabaro, L Paladin, M Necci, I Mičetić, C Camilloni, N Davey, ... Nucleic acids research 46 (D1), D471-D476, 2018 | 185 | 2018 |
| Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, ... Nature communications 10 (1), 1-11, 2019 | 119 | 2019 |
| Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, ... Science advances 3 (6), e1700488, 2017 | 114 | 2017 |
| Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins P Sormanni, FA Aprile, M Vendruscolo Proceedings of the National Academy of Sciences 112 (32), 9902-9907, 2015 | 110 | 2015 |
| Simultaneous quantification of protein order and disorder P Sormanni, D Piovesan, GT Heller, M Bonomi, P Kukic, C Camilloni, ... Nature chemical biology 13 (4), 339-342, 2017 | 103 | 2017 |
| Rapid and accurate in silico solubility screening of a monoclonal antibody library P Sormanni, L Amery, S Ekizoglou, M Vendruscolo, B Popovic Scientific reports 7 (1), 1-9, 2017 | 94 | 2017 |
| Parapred: antibody paratope prediction using convolutional and recurrent neural networks E Liberis, P Veličković, P Sormanni, M Vendruscolo, P Liò Bioinformatics 34 (17), 2944-2950, 2018 | 92 | 2018 |
| A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease R Freer, P Sormanni, G Vecchi, P Ciryam, CM Dobson, M Vendruscolo Science advances 2 (8), e1600947, 2016 | 87 | 2016 |
| The s2D method: simultaneous sequence-based prediction of the statistical populations of ordered and disordered regions in proteins P Sormanni, C Camilloni, P Fariselli, M Vendruscolo Journal of molecular biology 427 (4), 982-996, 2015 | 86 | 2015 |
| Third generation antibody discovery methods: in silico rational design P Sormanni, FA Aprile, M Vendruscolo Chemical Society Reviews 47 (24), 9137-9157, 2018 | 82 | 2018 |
| Proteome-wide observation of the phenomenon of life on the edge of solubility G Vecchi, P Sormanni, B Mannini, A Vandelli, GG Tartaglia, CM Dobson, ... Proceedings of the National Academy of Sciences 117 (2), 1015-1020, 2020 | 76 | 2020 |
| Targeting disordered proteins with small molecules using entropy GT Heller, P Sormanni, M Vendruscolo Trends in biochemical sciences 40 (9), 491-496, 2015 | 76 | 2015 |
| Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability C Camilloni, BM Sala, P Sormanni, R Porcari, A Corazza, M De Rosa, ... Scientific reports 6 (1), 1-11, 2016 | 56 | 2016 |
| In vitro and in silico assessment of the developability of a designed monoclonal antibody library AM Wolf Pérez, P Sormanni, JS Andersen, LI Sakhnini, I Rodriguez-Leon, ... MAbs 11 (2), 388-400, 2019 | 55 | 2019 |
| Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein S Gianni, C Camilloni, R Giri, A Toto, D Bonetti, A Morrone, P Sormanni, ... Proceedings of the National Academy of Sciences 111 (39), 14141-14146, 2014 | 53 | 2014 |
| Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity T Le Marchand, M de Rosa, N Salvi, BM Sala, LB Andreas, ... Nature communications 9 (1), 1-11, 2018 | 49 | 2018 |
| Oxetane Grafts Installed Site‐Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo N Martínez‐Sáez, S Sun, D Oldrini, P Sormanni, O Boutureira, F Carboni, ... Angewandte Chemie International Edition 56 (47), 14963-14967, 2017 | 49 | 2017 |
| Developability assessment of engineered monoclonal antibody variants with a complex self-association behavior using complementary analytical and in silico tools L Shan, N Mody, P Sormani, KL Rosenthal, MM Damschroder, ... Molecular pharmaceutics 15 (12), 5697-5710, 2018 | 47 | 2018 |
Michele VendruscoloProfessor of Biophysics, University of CambridgeVerified email at cam.ac.uk
