Chenguang Lou
TitleCited byYear
Next-generation bis-locked nucleic acids with stacking linker and 2-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes
S Geny, PMD Moreno, T Krzywkowski, O Gissberg, NK Andersen, AJ Isse, ...
Nucleic Acids Research 44 (5), 2007-2019, 2016
202016
Enhanced H-bonding and π-stacking in DNA: a potent duplex-stabilizing and mismatch sensing nucleobase analogue
C Lou, A Dallmann, P Marafini, R Gao, T Brown
Chemical Science 5 (10), 3836 - 3844, 2014
172014
Synthesis and properties of triplex-forming oligonucleotides containing 2′-O-(2-methoxyethyl)-5-(3-aminoprop-1-ynyl)-uridine
C Lou, Q Xiao, L Brennan, ME Light, N Vergara-Irigaray, EM Atkinson, ...
Bioorganic & medicinal chemistry 18 (17), 6389-6397, 2010
142010
Peptide-oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic
C Lou, MC Martos-Maldonado, CS Madsen, RP Thomsen, SR Midtgaard, ...
Nature Communications 7, 12294, 2016
132016
Oligonucleotides containing a piperazino-modified 2′-amino-LNA monomer exhibit very high duplex stability and remarkable nuclease resistance
C Lou, B Vester, J Wengel
Chemical Communications 51 (19), 4024-4027, 2015
112015
2′‐Aminoethoxy‐2‐amino‐3‐methylpyridine in Triplex‐Forming Oligonucleotides: High Affinity, Selectivity and Resistance to Enzymatic Degradation
C Lou, M Shelbourne, KR Fox, T Brown
Chemistry–A European Journal 17 (52), 14851-14856, 2011
102011
2′-Substituted 2-amino-3-methylpyridine ribonucleosides in triplex-forming oligonucleotides: triplex stability is determined by chemical environment
C Lou, Q Xiao, RR Tailor, NB Gaied, N Gale, ME Light, KR Fox, T Brown
MedChemComm 2 (6), 550-558, 2011
102011
Oligonucleotides Containing Aminated 2’-Amino-LNA Nucleotides: Synthesis and Strong Binding to Complementary DNA and RNA
C Lou, SV Samuelsen, NJ Christensen, B Vester, J Wengel
Bioconjugate Chemistry 28 (4), 1214−1220, 2017
92017
Folding Topology of a Short Coiled Coil Peptide Structure Templated by an Oligonucleotide Triplex
C Lou, NJ Christensen, MC Martos-Maldonado, SR Midtgaard, M Ejlersen, ...
Chemistry-A European Journal 23 (39), 9297 –9305, 2017
52017
Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions
M Ejlersen, C Lou, YS Sanghvi, Y Tor, J Wengel
Chemical Communications 54 (57), 8003-8006, 2018
42018
Synthesis and Biophysical Investigations of Oligonucleotides Containing Galactose-Modified DNA, LNA and 2ʹ-Amino-LNA Monomers
A Ries, R Kumar, C Lou, T Kosbar, E Vengut-Climent, PT Jørgensen, ...
The Journal of Organic Chemistry 81 (22), 10845–10856, 2016
32016
Synergy of two highly specific biomolecular recognition events: aligning an AT-hook peptide in DNA minor grooves via covalent conjugation to 2ʹ-amino-LNA
M Ejlersen, NJ Christensen, KK Sørensen, KJ Jensen, J Wengel, C Lou
Bioconjugate chemistry 29 (4), 1025–1029, 2018
12018
Gapmer antisense oligonucleotides containing 2’, 3’‐dideoxy‐2’‐fluoro‐3’‐C‐hydroxymethyl‐β‐D‐lyxofuranosyl nucleotides display site‐specific RNase H cleavage and induce gene …
MB Danielsen, C Lou, J Lisowiec-Wachnicka, A Pasternak, PT Jørgensen, ...
Chemistry–A European Journal, 2019
2019
Albumin-binding fatty acid-modified gapmer antisense oligonucleotides for modulation of pharmacokinetics
Y Cai, C Lou, J Wengel, K Howard
Methods in Molecular Biology, 2019
2019
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Articles 1–14