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Cristina Cecchi
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A causative link between the structure of aberrant protein oligomers and their toxicity
S Campioni, B Mannini, M Zampagni, A Pensalfini, C Parrini, ...
Nature chemical biology 6 (2), 140-147, 2010
5752010
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
G Fusco, SW Chen, PTF Williamson, R Cascella, M Perni, JA Jarvis, ...
Science 358 (6369), 1440-1443, 2017
3952017
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ...
Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017
2292017
Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer’s patients
C Cecchi, C Fiorillo, S Sorbi, S Latorraca, B Nacmias, S Bagnoli, P Nassi, ...
Free Radical Biology and Medicine 33 (10), 1372-1379, 2002
1982002
Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity
B Mannini, E Mulvihill, C Sgromo, R Cascella, R Khodarahmi, ...
ACS chemical biology 9 (10), 2309-2317, 2014
1722014
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers
B Mannini, R Cascella, M Zampagni, M van Waarde-Verhagen, S Meehan, ...
Proceedings of the National Academy of Sciences 109 (31), 12479-12484, 2012
1502012
Gluthatione level is altered in lymphoblasts from patients with familial Alzheimer's disease
C Cecchi, S Latorraca, S Sorbi, T Iantomasi, F Favilli, MT Vincenzini, ...
Neuroscience letters 275 (2), 152-154, 1999
1401999
SIRT1 modulates MAPK pathways in ischemic–reperfused cardiomyocytes
M Becatti, N Taddei, C Cecchi, N Nassi, PA Nassi, C Fiorillo
Cellular and Molecular Life Sciences 69 (13), 2245-2260, 2012
1242012
Insights into the molecular basis of the differing susceptibility of varying cell types to the toxicity of amyloid aggregates
C Cecchi, S Baglioni, C Fiorillo, A Pensalfini, G Liguri, D Nosi, S Rigacci, ...
Journal of Cell Science 118 (15), 3459-3470, 2005
1062005
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, ...
Nature communications 10 (1), 1-13, 2019
962019
The amyloid-cell membrane system. The interplay between the biophysical features of oligomers/fibrils and cell membrane defines amyloid toxicity
C Cecchi, M Stefani
Biophysical chemistry 182, 30-43, 2013
962013
Curcumin protects cardiac cells against ischemia-reperfusion injury: effects on oxidative stress, NF-κB, and JNK pathways
C Fiorillo, M Becatti, A Pensalfini, C Cecchi, L Lanzilao, G Donzelli, ...
Free Radical Biology and Medicine 45 (6), 839-846, 2008
932008
Seladin‐1/DHCR24 protects neuroblastoma cells against Aβ toxicity by increasing membrane cholesterol content
C Cecchi, F Rosati, A Pensalfini, L Formigli, D Nosi, G Liguri, F Dichiara, ...
Journal of cellular and molecular medicine 12 (5b), 1990-2002, 2008
892008
Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases
E Evangelisti, R Cascella, M Becatti, G Marrazza, CM Dobson, F Chiti, ...
Scientific reports 6 (1), 1-14, 2016
872016
Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers
E Evangelisti, C Cecchi, R Cascella, C Sgromo, M Becatti, CM Dobson, ...
Journal of cell science 125 (10), 2416-2427, 2012
832012
A protective role for lipid raft cholesterol against amyloid-induced membrane damage in human neuroblastoma cells
C Cecchi, D Nichino, M Zampagni, C Bernacchioni, E Evangelisti, ...
Biochimica et Biophysica Acta (BBA)-Biomembranes 1788 (10), 2204-2216, 2009
772009
Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro
R Cascella, S Conti, B Mannini, X Li, JN Buxbaum, B Tiribilli, F Chiti, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1832 (12 …, 2013
762013
Extracellular chaperones prevent Aβ42-induced toxicity in rat brains
R Cascella, S Conti, F Tatini, E Evangelisti, T Scartabelli, F Casamenti, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1832 (8 …, 2013
692013
TDP-43 inclusion bodies formed in bacteria are structurally amorphous, non-amyloid and inherently toxic to neuroblastoma cells
C Capitini, S Conti, M Perni, F Guidi, R Cascella, A De Poli, A Penco, ...
PloS one 9 (1), e86720, 2014
672014
Increased susceptibility to amyloid toxicity in familial Alzheimer's fibroblasts
C Cecchi, C Fiorillo, S Baglioni, A Pensalfini, S Bagnoli, B Nacmias, ...
Neurobiology of aging 28 (6), 863-876, 2007
672007
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