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Christopher R. Horne
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Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis
SE Garnish, Y Meng, A Koide, JJ Sandow, E Denbaum, AV Jacobsen, ...
Nature communications 12 (1), 2211, 2021
562021
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis
Y Meng, KA Davies, C Fitzgibbon, SN Young, SE Garnish, CR Horne, ...
Nature Communications 12 (1), 6783, 2021
412021
A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells
AL Samson, C Fitzgibbon, KM Patel, JM Hildebrand, LW Whitehead, ...
Cell Death & Differentiation 28 (7), 2126-2144, 2021
392021
“Just a spoonful of sugar...”: import of sialic acid across bacterial cell membranes
RA North, CR Horne, JS Davies, DM Remus, AC Muscroft-Taylor, P Goyal, ...
Biophysical Reviews 10, 219-227, 2018
382018
Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL
A Sethi, CR Horne, C Fitzgibbon, K Wilde, KA Davies, SE Garnish, ...
Cell Death & Differentiation 29 (9), 1804-1815, 2022
212022
The web of death: the expanding complexity of necroptotic signaling
CR Horne, AL Samson, JM Murphy
Trends in Cell Biology, 2023
182023
Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism
CR Horne, H Venugopal, S Panjikar, DM Wood, A Henrickson, E Brookes, ...
Nature communications 12 (1), 1988, 2021
182021
Functional and solution structure studies of amino sugar deacetylase and deaminase enzymes from Staphylococcus aureus
JS Davies, D Coombes, CR Horne, FG Pearce, R Friemann, RA North, ...
FEBS letters 593 (1), 52-66, 2019
172019
Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2
AV Peskin, FC Meotti, KM Kean, C Göbl, AS Peixoto, PE Pace, CR Horne, ...
Journal of Biological Chemistry 296, 2021
142021
Multi-wavelength analytical ultracentrifugation as a tool to characterise protein–DNA interactions in solution
CR Horne, A Henrickson, B Demeler, RCJ Dobson
European Biophysics Journal 49 (8), 819-827, 2020
142020
On the structure and function of Escherichia coli YjhC: An oxidoreductase involved in bacterial sialic acid metabolism
CR Horne, L Kind, JS Davies, RCJ Dobson
Proteins: Structure, Function, and Bioinformatics 88 (5), 654-668, 2020
142020
The basis for non-canonical ROK family function in the N-acetylmannosamine kinase from the pathogen Staphylococcus aureus
D Coombes, JS Davies, MC Newton-Vesty, CR Horne, TG Setty, ...
Journal of Biological Chemistry 295 (10), 3301-3315, 2020
122020
Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker
BC Lechtenberg, MP Gehring, TP Light, CR Horne, MW Matsumoto, ...
Nature communications 12 (1), 7047, 2021
112021
The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs
LY Liang, M Roy, CR Horne, JJ Sandow, M Surudoi, LF Dagley, ...
Biochemical Journal 478 (17), 3351-3371, 2021
92021
Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling
Y Meng, CR Horne, AL Samson, LF Dagley, SN Young, JJ Sandow, ...
Cell Death & Disease 13 (6), 565, 2022
72022
Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix
MR Oliver, CR Horne, S Shrestha, JR Keown, LY Liang, SN Young, ...
Nature Communications 12 (1), 1002, 2021
72021
Using cryo-EM to uncover mechanisms of bacterial transcriptional regulation
DM Wood, RCJ Dobson, CR Horne
Biochemical Society Transactions 49 (6), 2711-2726, 2021
52021
N-acetylmannosamine-6-phosphate 2-epimerase uses a novel substrate-assisted mechanism to catalyze amino sugar epimerization
MJ Currie, L Manjunath, CR Horne, PM Rendle, R Subramanian, ...
Journal of Biological Chemistry 297 (4), 2021
42021
A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation
SE Garnish, KR Martin, M Kauppi, VE Jackson, R Ambrose, VV Eng, ...
Nature Communications 14 (1), 6046, 2023
32023
Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL
T Sadras, FB Jalud, HJ Kosasih, CR Horne, LM Brown, S El-Kamand, ...
Leukemia 37 (4), 905-909, 2023
32023
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