John K. Walker
John K. Walker
Saint Louis University, Pfizer, University of Missouri-St. Louis
Verified email at slu.edu - Homepage
Title
Cited by
Cited by
Year
Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis
CA Flaveny, K Griffett, BEDM El-Gendy, M Kazantzis, M Sengupta, ...
Cancer cell 28 (1), 42-56, 2015
942015
Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804
L Xing, HS Shieh, SR Selness, RV Devraj, JK Walker, B Devadas, ...
Biochemistry 48 (27), 6402-6411, 2009
562009
Substituted pyridinones
B Devadas, J Walker, S Selness, T Boehm, R Durley, R Devraj, B Hickory, ...
US Patent App. 10/918,826, 2005
512005
New fluorobutenolide templates for synthesis
TB Patrick, MV Lanahan, C Yang, JK Walker, CL Hutchinson, BE Neal
The Journal of Organic Chemistry 59 (5), 1210-1212, 1994
511994
Substituted pyridinones
B Devadas, J Walker, SR Selness, TL Boehm, RC Durley, R Devraj, ...
US Patent 7,067,540, 2006
502006
Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase
SR Selness, RV Devraj, B Devadas, JK Walker, TL Boehm, RC Durley, ...
Bioorganic & medicinal chemistry letters 21 (13), 4066-4071, 2011
352011
Substituted pyrazoles as p38 kinase inhibitors
AS Naraian, M Clare, PW Collins, JZ Crich, R Devraj, DL Flynn, L Geng, ...
US Patent 6,979,686, 2005
352005
1-(2-(2, 2, 2-Trifluoroethoxy) ethyl-1H-pyrazolo [4, 3-d] pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors
MB Tollefson, BA Acker, EJ Jacobsen, RO Hughes, JK Walker, DNA Fox, ...
Bioorganic & medicinal chemistry letters 20 (10), 3125-3128, 2010
332010
Reviving antibiotics: efflux pump inhibitors that interact with AcrA, a membrane fusion protein of the AcrAB-TolC multidrug efflux pump
N Abdali, JM Parks, KM Haynes, JL Chaney, AT Green, D Wolloscheck, ...
ACS infectious diseases 3 (1), 89-98, 2017
322017
Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase
SR Selness, RV Devraj, JB Monahan, TL Boehm, JK Walker, B Devadas, ...
Bioorganic & medicinal chemistry letters 19 (20), 5851-5856, 2009
312009
Cationic [5+ 2] cycloaddition reactions promoted by trimethylsilyl triflate in highly polar media
JL Collins, PA Grieco, JK Walker
Tetrahedron letters 38 (8), 1321-1324, 1997
281997
Discovery and characterization of atropisomer PH‐797804, a p38 MAP kinase inhibitor, as a clinical drug candidate
L Xing, B Devadas, RV Devraj, SR Selness, H Shieh, JK Walker, M Mao, ...
ChemMedChem 7 (2), 273-280, 2012
262012
Intramolecular cationic [5+ 2] cycloaddition reactions promoted by trimethylsilyl triflate in 3.0 M lithium perchlorate-ethyl acetate: Application to a formal total synthesis …
PA Grieco, JK Walker
Tetrahedron 53 (26), 8975-8996, 1997
251997
Acute Lymphoid and Gastrointestinal Toxicity Induced by Selective p38α Map Kinase and Map Kinase–Activated Protein Kinase-2 (MK2) Inhibitors in the Dog
DL Morris, SP O’Neil, RV Devraj, JP Portanova, RW Gilles, CJ Gross, ...
Toxicologic pathology 38 (4), 606-618, 2010
242010
Identification, synthesis and SAR of amino substituted pyrido [3, 2b] pyrazinones as potent and selective PDE5 inhibitors
DR Owen, JK Walker, EJ Jacobsen, JN Freskos, RO Hughes, DL Brown, ...
Bioorganic & medicinal chemistry letters 19 (15), 4088-4091, 2009
212009
Identification and Structure–Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli
KM Haynes, N Abdali, V Jhawar, HI Zgurskaya, JM Parks, AT Green, ...
Journal of medicinal chemistry 60 (14), 6205-6219, 2017
202017
Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase
JK Walker, SR Selness, RV Devraj, ME Hepperle, W Naing, H Shieh, ...
Bioorganic & medicinal chemistry letters 20 (8), 2634-2638, 2010
202010
Substituted pyridazinones
M Hepperle, K Jerome, J Walker, S Selness, R Devraj
US Patent App. 10/893,073, 2005
202005
Substituted pyridazinones
M Hepperle, K Jerome, J Walker, S Selness, R Devraj
US Patent App. 10/893,073, 2005
202005
Therapeutic effect of a synthetic RORα/γ agonist in an animal model of autism
Y Wang, C Billon, JK Walker, TP Burris
ACS chemical neuroscience 7 (2), 143-148, 2016
172016
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