| Control and regulation of the cellular responses to cold shock: the responses in yeast and mammalian systems MB Al-Fageeh, CM Smales Biochemical Journal 397 (2), 247-259, 2006 | 334 | 2006 |
| How can thermal processing modify the antigenicity of proteins? PJ Davis, CM Smales, DC James Allergy 56, 56-60, 2001 | 239 | 2001 |
| Credit/financing process JM Lazerson US Patent 7,680,728, 2010 | 198 | 2010 |
| The cold‐shock response in cultured mammalian cells: Harnessing the response for the improvement of recombinant protein production MB Al‐Fageeh, RJ Marchant, MJ Carden, CM Smales Biotechnology and bioengineering 93 (5), 829-835, 2006 | 197 | 2006 |
| The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk‐based management for their control DG Bracewell, R Francis, CM Smales Biotechnology and bioengineering 112 (9), 1727-1737, 2015 | 167 | 2015 |
| Biochemical and structural insights into bacterial organelle form and biogenesis JB Parsons, SD Dinesh, E Deery, HK Leech, AA Brindley, D Heldt, ... Journal of biological chemistry 283 (21), 14366-14375, 2008 | 163 | 2008 |
| Comparative proteomic analysis of GS‐NS0 murine myeloma cell lines with varying recombinant monoclonal antibody production rate CM Smales, DM Dinnis, SH Stansfield, D Alete, EA Sage, JR Birch, ... Biotechnology and bioengineering 88 (4), 474-488, 2004 | 151 | 2004 |
| Host cell protein dynamics in the supernatant of a mAb producing CHO cell line AS Tait, CEM Hogwood, CM Smales, DG Bracewell Biotechnology and Bioengineering 109 (4), 971-982, 2012 | 136 | 2012 |
| Comparison of the effects of 2, 2, 2-trifluoroethanol on peptide and protein structure and function JF Povey, CM Smales, SJ Hassard, MJ Howard Journal of Structural Biology 157 (2), 329-338, 2007 | 133 | 2007 |
| The dynamics of the CHO host cell protein profile during clarification and protein A capture in a platform antibody purification process CEM Hogwood, AS Tait, N Koloteva‐Levine, DG Bracewell, CM Smales Biotechnology and bioengineering 110 (1), 240-251, 2013 | 128 | 2013 |
| Biochemical insights into the mechanisms central to the response of mammalian cells to cold stress and subsequent rewarming A Roobol, MJ Carden, RJ Newsam, CM Smales The FEBS journal 276 (1), 286-302, 2009 | 122 | 2009 |
| Host cell protein adsorption characteristics during protein A chromatography RDR Tarrant, ML Velez‐Suberbie, AS Tait, CM Smales, DG Bracewell Biotechnology progress 28 (4), 1037-1044, 2012 | 104 | 2012 |
| Cold-inducible RNA binding protein (CIRP) expression is modulated by alternative mRNAs MB Al-Fageeh, CM Smales Rna 15 (6), 1164-1176, 2009 | 104 | 2009 |
| Measurement and control of host cell proteins (HCPs) in CHO cell bioprocesses CEM Hogwood, DG Bracewell, CM Smales Current opinion in biotechnology 30, 153-160, 2014 | 103 | 2014 |
| Control of translation elongation in health and disease JRP Knight, G Garland, T Pöyry, E Mead, N Vlahov, A Sfakianos, ... Disease models & mechanisms 13 (3), dmm043208, 2020 | 77 | 2020 |
| Functional proteomic analysis of GS‐NS0 murine myeloma cell lines with varying recombinant monoclonal antibody production rate DM Dinnis, SH Stansfield, S Schlatter, CM Smales, D Alete, JR Birch, ... Biotechnology and bioengineering 94 (5), 830-841, 2006 | 75 | 2006 |
| Engineering an improved IgG4 molecule with reduced disulfide bond heterogeneity and increased Fab domain thermal stability SJ Peters, CM Smales, AJ Henry, PE Stephens, S West, DP Humphreys Journal of Biological Chemistry 287 (29), 24525-24533, 2012 | 72 | 2012 |
| mTORC1 signalling and eIF4E/4E-BP1 translation initiation factor stoichiometry influence recombinant protein productivity from GS-CHOK1 cells L Jossé, J Xie, CG Proud, CM Smales Biochemical Journal 473 (24), 4651-4664, 2016 | 68 | 2016 |
| RTN3 is a novel cold-induced protein and mediates neuroprotective effects of RBM3 A Bastide, D Peretti, JRP Knight, S Grosso, RV Spriggs, X Pichon, ... Current Biology 27 (5), 638-650, 2017 | 67 | 2017 |
| Metabolic rates, growth phase, and mRNA levels influence cell-specific antibody production levels from in vitro-cultured mammalian cells at sub-physiological temperatures RJ Marchant, MB Al-Fageeh, MF Underhill, AJ Racher, CM Smales Molecular biotechnology 39, 69-77, 2008 | 64 | 2008 |
