Madan Kharel
Madan Kharel
Assistant Prof. of Pharmaceutical sciences, University of Maryland Eastern Shore
Verified email at - Homepage
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Cited by
Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis
MK Kharel, P Pahari, MD Shepherd, N Tibrewal, SE Nybo, KA Shaaban, ...
Natural product reports 29 (2), 264-325, 2012
A comprehensive review of glycosylated bacterial natural products
SI Elshahawi, KA Shaaban, MK Kharel, JS Thorson
Chemical Society Reviews 44 (21), 7591-7697, 2015
Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration
SF Sleiman, BC Langley, M Basso, J Berlin, L Xia, JB Payappilly, ...
Journal of Neuroscience 31 (18), 6858-6870, 2011
Isolation and characterization of the tobramycin biosynthetic gene cluster from Streptomyces tenebrarius
MK Kharel, DB Basnet, HC Lee, K Liou, JS Woo, BG Kim, JK Sohng
FEMS microbiology letters 230 (2), 185-190, 2004
A gene cluster for biosynthesis of kanamycin from Streptomyces kanamyceticus: comparison with gentamicin biosynthetic gene cluster
MK Kharel, B Subba, DB Basnet, JS Woo, HC Lee, K Liou, JK Sohng
Archives of biochemistry and biophysics 429 (2), 204-214, 2004
Baeyer–Villiger C–C bond cleavage reaction in gilvocarcin and jadomycin biosynthesis
N Tibrewal, P Pahari, G Wang, MK Kharel, C Morris, T Downey, Y Hou, ...
Journal of the American Chemical Society 134 (44), 18181-18184, 2012
Multi-oxygenase complexes of the gilvocarcin and jadomycin biosyntheses
MK Kharel, L Zhu, T Liu, J Rohr
Journal of the American Chemical Society 129 (13), 3780-3781, 2007
Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis
P Pahari, MK Kharel, MD Shepherd, SG van Lanen, J Rohr
Angewandte Chemie 124 (5), 1242-1246, 2012
Laboratory Maintenance of Streptomyces Species
MD Shepherd, MK Kharel, MA Bosserman, J Rohr
Current protocols in microbiology 18 (1), 10E. 1.1-10E. 1.8, 2010
On the Acceptor Substrate of C‐Glycosyltransferase UrdGT2: Three Prejadomycin C‐Glycosides from an Engineered Mutant of Streptomyces globisporus 1912 ΔlndE (urdGT2)
I Baig, M Kharel, A Kobylyanskyy, L Zhu, Y Rebets, B Ostash, ...
Angewandte Chemie International Edition 45 (46), 7842-7846, 2006
Molecular cloning and characterization of a 2-deoxystreptamine biosynthetic gene cluster in gentamicin-producing Micromonospora echinospora ATCC15835.
MK Kharel, DB Basnet, HC Lee, K Liou, YH Moon, JJ Kim, JS Woo, ...
Molecules & Cells (Springer Science & Business Media BV) 18 (1), 2004
Frenolicins C–G, Pyranonaphthoquinones from Streptomyces sp. RM-4-15
X Wang, KA Shaaban, SI Elshahawi, LV Ponomareva, M Sunkara, ...
Journal of natural products 76 (8), 1441-1447, 2013
Cloning and characterization of the ravidomycin and chrysomycin biosynthetic gene clusters
MK Kharel, SE Nybo, MD Shepherd, J Rohr
ChemBioChem 11 (4), 523-532, 2010
Inactivation of gilGT, Encoding a C‐Glycosyltransferase, and gilOIII, Encoding a P450 Enzyme, Allows the Details of the Late Biosynthetic Pathway to Gilvocarcin …
T Liu, MK Kharel, C Fischer, A McCormick, J Rohr
ChemBioChem 7 (7), 1070-1077, 2006
Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic
MK Kharel, P Pahari, H Lian, J Rohr
Organic letters 12 (12), 2814-2817, 2010
Moromycins A and B, Isolation and Structure Elucidation of C-Glycosylangucycline-Type Antibiotics from Streptomyces sp. KY002
MS Abdelfattah, MK Kharel, JA Hitron, I Baig, J Rohr
Journal of natural products 71 (9), 1569-1573, 2008
The ribostamycin biosynthetic gene cluster in Streptomyces ribosidificus: comparison with butirosin biosynthesis.
B Subba, MK Kharel, HC Lee, K Liou, BG Kim, JK Sohng
Molecules & Cells (Springer Science & Business Media BV) 20 (1), 2005
GilR, an Unusual Lactone‐Forming Enzyme Involved in Gilvocarcin Biosynthesis
MK Kharel, P Pahari, H Lian, J Rohr
ChemBioChem 10 (8), 1305-1308, 2009
Inactivation of the ketoreductase gilU gene of the gilvocarcin biosynthetic gene cluster yields new analogues with partly improved biological activity
T Liu, MK Kharel, L Zhu, SA Bright, C Mattingly, VR Adams, J Rohr
Chembiochem: a European journal of chemical biology 10 (2), 278, 2009
Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691
KA Shaaban, SI Elshahawi, X Wang, J Horn, MK Kharel, M Leggas, ...
Journal of natural products 78 (7), 1723-1729, 2015
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