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Thibault Annaval
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Heparan sulfate proteoglycans biosynthesis and post synthesis mechanisms combine few enzymes and few core proteins to generate extensive structural and functional diversity
T Annaval, R Wild, Y Crétinon, R Sadir, RR Vivès, H Lortat-Jacob
Molecules 25 (18), 4215, 2020
642020
Characterization of Intersubunit Communication in the Virginiamycin trans-Acyl Transferase Polyketide Synthase
J Dorival, T Annaval, F Risser, S Collin, P Roblin, C Jacob, A Gruez, ...
Journal of the American Chemical Society 138 (12), 4155-4167, 2016
462016
Evaluating ketoreductase exchanges as a means of rationally altering polyketide stereochemistry
T Annaval, C Paris, PF Leadlay, C Jacob, KJ Weissman
ChemBioChem 16 (9), 1357-1364, 2015
452015
Comparative studies of the biosynthetic gene clusters for anthraquinone-fused enediynes shedding light into the tailoring steps of tiancimycin biosynthesis
X Yan, JJ Chen, A Adhikari, CN Teijaro, H Ge, I Crnovcic, CY Chang, ...
Organic Letters 20 (18), 5918-5921, 2018
392018
ADAPTABLE: A comprehensive web platform of antimicrobial peptides tailored to the user’s research
F Ramos-Martín, T Annaval, S Buchoux, C Sarazin, N D’amelio
Life science alliance 2 (6), 2019
282019
Resistance to enediyne antitumor antibiotics by sequestration
CY Chang, X Yan, I Crnovcic, T Annaval, C Chang, B Nocek, JD Rudolf, ...
Cell chemical biology 25 (9), 1075-1085. e4, 2018
232018
Biochemical and structural characterization of TtnD, a prenylated FMN-dependent decarboxylase from the tautomycetin biosynthetic pathway
T Annaval, L Han, JD Rudolf, G Xie, D Yang, CY Chang, M Ma, I Crnovcic, ...
ACS Chemical Biology 13 (9), 2728-2738, 2018
232018
Characterization of TnmH as an O-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody …
A Adhikari, CN Teijaro, X Yan, CY Chang, C Gui, YC Liu, I Crnovcic, ...
Journal of medicinal chemistry 63 (15), 8432-8441, 2020
192020
Discovery of alternative producers of the enediyne antitumor antibiotic C-1027 with high titers
X Yan, Hindra, H Ge, D Yang, T Huang, I Crnovcic, CY Chang, SM Fang, ...
Journal of natural products 81 (3), 594-599, 2018
142018
Crystal structure of thioesterase SgcE10 supporting common polyene intermediates in 9-and 10-membered enediyne core biosynthesis
T Annaval, JD Rudolf, CY Chang, JR Lohman, Y Kim, L Bigelow, ...
ACS omega 2 (8), 5159-5169, 2017
122017
Cytochrome P450 hydroxylase TnmL catalyzing sequential hydroxylation with an additional proofreading activity in tiancimycin biosynthesis
T Annaval, CN Teijaro, A Adhikari, X Yan, JJ Chen, I Crnovcic, D Yang, ...
ACS chemical biology 16 (7), 1172-1178, 2021
102021
Hindra; Babnigg, G.; et al
CY Chang, X Yan, I Crnovcic, T Annaval, C Chang, B Nocek, JD Rudolf, ...
Resistance to enediyne antitumor antibiotics by sequestration. Cell Chem …, 2018
72018
Antimicrobial bombinin-like peptide 3 selectively recognizes and inserts into bacterial biomimetic bilayers in multiple steps
T Annaval, F Ramos-Martin, C Herrera-Leon, M Adelaide, V Antonietti, ...
Journal of Medicinal Chemistry 64 (8), 5185-5197, 2021
62021
Functional characterization of cytochrome P450 hydroxylase YpmL in yangpumicin A biosynthesis and its application for anthraquinone-fused enediyne structural diversification
D Yang, F Ye, CN Teijaro, D Hwang, T Annaval, A Adhikari, G Li, X Yan, ...
Organic letters 24 (5), 1219-1223, 2022
42022
Functional and structural insights into human N‐deacetylase/N‐sulfotransferase activities
SD Vallet, T Annaval, RR Vives, E Richard, J Hénault, C Le Narvor, ...
Proteoglycan Research 1 (3), e8, 2023
32023
Étude multidisciplinaire des aspects clés de la biosynthèse des polykétides par des polykétide synthases modulaires
T Annaval
Université de Lorraine, 2015
12015
Discovery and diversification of tiancimycin (TMN) natural products for Antibody Drug Conjugates (ADCs)
C Teijaro, A Adhikari, X Yan, T Annaval, I Crnovcic, CY Chang, C Rader, ...
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 257, 2019
2019
ADAPTABLE: a web platform for antimicrobial peptides
F Ramos-Martin, T Annaval, S Buchoux, C Sarazin, N d'Amelio
European Biophysics Journal 48 (1), S224, 2019
2019
Enediyne diversification by a cofactor-promiscuous methyltransferase
A Adhikari, X Yan, T Annaval, I Crnovcic, CY Chang, B Shen
Natural Product Discovery and Development in the Genomic Era, 2018
2018
Comparative studies of the biosynthetic pathways for anthraquinone-fused enediynes
X Yan, J Chen, T Annaval, A Adhikari, I Crnovcic, CY Chang, D Yang, ...
Natural Product Discovery and Development in the Genomic Era, 2018
2018
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