| Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells L Gattinoni, SE Finkelstein, CA Klebanoff, PA Antony, DC Palmer, ... The Journal of experimental medicine 202 (7), 907-912, 2005 | 1214 | 2005 |
| Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells CA Klebanoff, L Gattinoni, P Torabi-Parizi, K Kerstann, AR Cardones, ... Proceedings of the national academy of sciences 102 (27), 9571-9576, 2005 | 1176 | 2005 |
| Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells L Gattinoni, CA Klebanoff, DC Palmer, C Wrzesinski, K Kerstann, Z Yu, ... The Journal of clinical investigation 115 (6), 1616-1626, 2005 | 1173 | 2005 |
| Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8+ T Cells WW Overwijk, MR Theoret, SE Finkelstein, DR Surman, LA De Jong, ... The Journal of experimental medicine 198 (4), 569-580, 2003 | 1122 | 2003 |
| Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells L Gattinoni, XS Zhong, DC Palmer, Y Ji, CS Hinrichs, Z Yu, C Wrzesinski, ... Nature medicine 15 (7), 808-813, 2009 | 1075 | 2009 |
| Tumor-specific Th17-polarized cells eradicate large established melanoma P Muranski, A Boni, PA Antony, L Cassard, KR Irvine, A Kaiser, ... Blood, The Journal of the American Society of Hematology 112 (2), 362-373, 2008 | 1016 | 2008 |
| CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells PA Antony, CA Piccirillo, A Akpinarli, SE Finkelstein, PJ Speiss, ... The Journal of Immunology 174 (5), 2591-2601, 2005 | 954 | 2005 |
| Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function M Sukumar, J Liu, Y Ji, M Subramanian, JG Crompton, Z Yu, ... The Journal of clinical investigation 123 (10), 4479-4488, 2013 | 900 | 2013 |
| IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells CA Klebanoff, SE Finkelstein, DR Surman, MK Lichtman, L Gattinoni, ... Proceedings of the National Academy of Sciences 101 (7), 1969-1974, 2004 | 676 | 2004 |
| Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling CM Paulos, C Wrzesinski, A Kaiser, CS Hinrichs, M Chieppa, L Cassard, ... The Journal of clinical investigation 117 (8), 2197-2204, 2007 | 606 | 2007 |
| Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy CA Klebanoff, HT Khong, PA Antony, DC Palmer, NP Restifo Trends in immunology 26 (2), 111-117, 2005 | 553 | 2005 |
| Ionic immune suppression within the tumour microenvironment limits T cell effector function R Eil, SK Vodnala, D Clever, CA Klebanoff, M Sukumar, JH Pan, ... Nature 537 (7621), 539-543, 2016 | 539 | 2016 |
| IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy CS Hinrichs, R Spolski, CM Paulos, L Gattinoni, KW Kerstann, DC Palmer, ... Blood, The Journal of the American Society of Hematology 111 (11), 5326-5333, 2008 | 514 | 2008 |
| Th17 cells are long lived and retain a stem cell-like molecular signature P Muranski, ZA Borman, SP Kerkar, CA Klebanoff, Y Ji, L Sanchez-Perez, ... Immunity 35 (6), 972-985, 2011 | 484 | 2011 |
| Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity CS Hinrichs, ZA Borman, L Cassard, L Gattinoni, R Spolski, Z Yu, ... Proceedings of the National Academy of Sciences 106 (41), 17469-17474, 2009 | 459 | 2009 |
| T cell stemness and dysfunction in tumors are triggered by a common mechanism SK Vodnala, R Eil, RJ Kishton, M Sukumar, TN Yamamoto, NH Ha, ... Science 363 (6434), eaau0135, 2019 | 399 | 2019 |
| Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy CS Hinrichs, ZA Borman, L Gattinoni, Z Yu, WR Burns, J Huang, ... Blood, The Journal of the American Society of Hematology 117 (3), 808-814, 2011 | 363 | 2011 |
| High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation Y Zhao, Z Zheng, CJ Cohen, L Gattinoni, DC Palmer, NP Restifo, ... Molecular therapy 13 (1), 151-159, 2006 | 357 | 2006 |
| Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics JG Crompton, M Sukumar, R Roychoudhuri, D Clever, A Gros, RL Eil, ... Cancer research 75 (2), 296-305, 2015 | 348 | 2015 |
| Mitochondrial membrane potential identifies cells with enhanced stemness for cellular therapy M Sukumar, J Liu, GU Mehta, SJ Patel, R Roychoudhuri, JG Crompton, ... Cell metabolism 23 (1), 63-76, 2016 | 344 | 2016 |
Nicholas P Restifo, MDCellular Immunotherapy ExplorerVerified email at marbletx.com
