| Stimulation of homologous recombination through targeted cleavage by chimeric nucleases M Bibikova, D Carroll, DJ Segal, JK Trautman, J Smith, YG Kim, ... Molecular and cellular biology 21 (1), 289-297, 2001 | 879 | 2001 |
| Toward controlling gene expression at will: Specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular … RR Beerli, DJ Segal, B Dreier, CF Barbas III Proceedings of the National Academy of Sciences 95 (25), 14628-14633, 1998 | 806 | 1998 |
| Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases M Szczepek, V Brondani, J Büchel, L Serrano, DJ Segal, T Cathomen Nature biotechnology 25 (7), 786-793, 2007 | 647 | 2007 |
| Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5′-GNN-3′ DNA target sequences DJ Segal, B Dreier, RR Beerli, CF Barbas III Proceedings of the National Academy of Sciences 96 (6), 2758-2763, 1999 | 599 | 1999 |
| Methods and compositions for using zinc finger endonucleases to enhance homologous recombination M Liljedahl, S Aspland, D Segal US Patent App. 10/395,816, 2003 | 509 | 2003 |
| Design of polydactyl zinc-finger proteins for unique addressing within complex genomes Q Liu, DJ Segal, JB Ghiara, CF Barbas III Proceedings of the National Academy of Sciences 94 (11), 5525-5530, 1997 | 483 | 1997 |
| Development of zinc finger domains for recognition of the 5′-ANN-3′ family of DNA sequences and their use in the construction of artificial transcription factors B Dreier, RR Beerli, DJ Segal, JD Flippin, CF Barbas Journal of Biological Chemistry 276 (31), 29466-29478, 2001 | 395 | 2001 |
| Keep your fingers off my DNA: protein–protein interactions mediated by C2H2 zinc finger domains KJ Brayer, DJ Segal Cell biochemistry and biophysics 50, 111-131, 2008 | 382 | 2008 |
| SRA-and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation LM Johnson, J Du, CJ Hale, S Bischof, S Feng, RK Chodavarapu, ... Nature 507 (7490), 124-128, 2014 | 333 | 2014 |
| Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain J Gallego-Bartolomé, J Gardiner, W Liu, A Papikian, B Ghoshal, HY Kuo, ... Proceedings of the National Academy of Sciences 115 (9), E2125-E2134, 2018 | 261 | 2018 |
| Development of zinc finger domains for recognition of the 5′-CNN-3′ family DNA sequences and their use in the construction of artificial transcription factors B Dreier, RP Fuller, DJ Segal, CV Lund, P Blancafort, A Huber, B Koksch, ... Journal of Biological Chemistry 280 (42), 35588-35597, 2005 | 258 | 2005 |
| A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture H O'Geen, IM Henry, MS Bhakta, JF Meckler, DJ Segal Nucleic acids research 43 (6), 3389-3404, 2015 | 257 | 2015 |
| Design, construction and in vitro testing of zinc finger nucleases D Carroll, JJ Morton, KJ Beumer, DJ Segal Nature protocols 1 (3), 1329-1341, 2006 | 252 | 2006 |
| Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins DJ Segal, RR Beerli, P Blancafort, B Dreier, K Effertz, A Huber, B Koksch, ... Biochemistry 42 (7), 2137-2148, 2003 | 249 | 2003 |
| Designing transcription factor architectures for drug discovery P Blancafort, DJ Segal, CF Barbas Molecular pharmacology 66 (6), 1361-1371, 2004 | 226 | 2004 |
| Custom zinc-finger nucleases for use in human cells S Alwin, MB Gere, E Guhl, K Effertz, CF Barbas, DJ Segal, MD Weitzman, ... Molecular Therapy 12 (4), 610-617, 2005 | 218 | 2005 |
| dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression H O’Geen, C Ren, CM Nicolet, AA Perez, J Halmai, VM Le, JP Mackay, ... Nucleic acids research 45 (17), 9901-9916, 2017 | 217 | 2017 |
| Insights into the molecular recognition of the 5′-GNN-3′ family of DNA sequences by zinc finger domains B Dreier, DJ Segal, CF Barbas III Journal of molecular biology 303 (4), 489-502, 2000 | 216 | 2000 |
| Quantitative analysis of TALE–DNA interactions suggests polarity effects JF Meckler, MS Bhakta, MS Kim, R Ovadia, CH Habrian, A Zykovich, A Yu, ... Nucleic acids research 41 (7), 4118-4128, 2013 | 214 | 2013 |
| Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites W Tan, K Zhu, DJ Segal, CF Barbas III, SA Chow Journal of virology 78 (3), 1301-1313, 2004 | 178 | 2004 |
