| Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation ME Figueroa, O Abdel-Wahab, C Lu, PS Ward, J Patel, A Shih, Y Li, ... Cancer cell 18 (6), 553-567, 2010 | 3136 | 2010 |
| IDH mutation impairs histone demethylation and results in a block to cell differentiation C Lu, PS Ward, GS Kapoor, D Rohle, S Turcan, O Abdel-Wahab, ... Nature, 2012 | 2196 | 2012 |
| IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype S Turcan, D Rohle, A Goenka, LA Walsh, F Fang, E Yilmaz, C Campos, ... Nature, 2012 | 2171 | 2012 |
| Metabolic Regulation of Epigenetics C Lu, CB Thompson Cell Metabolism 16 (1), 9-17, 2012 | 705 | 2012 |
| Hypoxia induces production of L-2-hydroxyglutarate AM Intlekofer, RG Dematteo, S Venneti, LWS Finley, C Lu, AR Judkins, ... Cell metabolism 22 (2), 304-311, 2015 | 487 | 2015 |
| Serine catabolism regulates mitochondrial redox control during hypoxia J Ye, J Fan, S Venneti, YW Wan, BR Pawel, J Zhang, LWS Finley, C Lu, ... Cancer discovery 4 (12), 1406-1417, 2014 | 452 | 2014 |
| The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism KE Wellen, C Lu, A Mancuso, JMS Lemons, M Ryczko, JW Dennis, ... Genes & development 24 (24), 2784-2799, 2010 | 449 | 2010 |
| The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape DN Weinberg, S Papillon-Cavanagh, H Chen, Y Yue, X Chen, ... Nature 573 (7773), 281-286, 2019 | 439 | 2019 |
| Ammonia-induced autophagy is independent of ULK1/ULK2 kinases H Cheong, T Lindsten, J Wu, C Lu, CB Thompson Proceedings of the National Academy of Sciences 108 (27), 11121, 2011 | 400 | 2011 |
| Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape C Lu, SU Jain, D Hoelper, D Bechet, RC Molden, L Ran, D Murphy, ... Science 352 (6287), 844-849, 2016 | 388 | 2016 |
| Therapeutic targets in cancer cell metabolism and autophagy H Cheong, C Lu, T Lindsten, CB Thompson Nature Biotechnology 30 (7), 671-678, 2012 | 386 | 2012 |
| DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia R Rampal, A Alkalin, J Madzo, A Vasanthakumar, E Pronier, J Patel, Y Li, ... Cell reports 9 (5), 1841-1855, 2014 | 309 | 2014 |
| H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis AS Harutyunyan, B Krug, H Chen, S Papillon-Cavanagh, M Zeinieh, ... Nature communications 10 (1), 1262, 2019 | 293 | 2019 |
| Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas S Papillon-Cavanagh, C Lu, T Gayden, LG Mikael, D Bechet, ... Nature genetics 49 (2), 180-185, 2017 | 249 | 2017 |
| Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition C Chen, Y Liu, C Lu, JR Cross, JP Morris, AS Shroff, PS Ward, JE Bradner, ... Genes & Development 27 (18), 1974-1985, 2013 | 220 | 2013 |
| Identification of additional IDH mutations associated with oncometabolite R (−)-2-hydroxyglutarate production PS Ward, JR Cross, C Lu, O Weigert, O Abel-Wahab, RL Levine, ... Oncogene, 2011 | 215 | 2011 |
| The Potential for Isocitrate Dehydrogenase Mutations to Produce 2-Hydroxyglutarate Depends on Allele Specificity and Subcellular Compartmentalization PS Ward, C Lu, JR Cross, O Abdel-Wahab, RL Levine, GK Schwartz, ... Journal of Biological Chemistry 288 (6), 3804-3815, 2013 | 195 | 2013 |
| Functional interrogation of DNA damage response variants with base editing screens R Cuella-Martin, SB Hayward, X Fan, X Chen, JW Huang, A Taglialatela, ... Cell 184 (4), 1081-1097. e19, 2021 | 192 | 2021 |
| Induction of sarcomas by mutant IDH2 C Lu, S Venneti, A Akalin, F Fang, PS Ward, RG DeMatteo, AM Intlekofer, ... Genes & Development 27 (18), 1986-1998, 2013 | 184 | 2013 |
| Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas J Bayliss, P Mukherjee, C Lu, SU Jain, C Chung, D Martinez, B Sabari, ... Science translational medicine 8 (366), 366ra161-366ra161, 2016 | 180 | 2016 |
Craig ThompsonMemorial Sloan Kettering Cancer CenterVerified email at mskcc.org
