Iridium complexes of CCC-pincer N-heterocyclic carbene ligands: synthesis and catalytic C− H functionalization AR Chianese, A Mo, NL Lampland, RL Swartz, PT Bremer Organometallics 29 (13), 3019-3026, 2010 | 154 | 2010 |
Combatting synthetic designer opioids: a conjugate vaccine ablates lethal doses of fentanyl class drugs PT Bremer, A Kimishima, JE Schlosburg, B Zhou, KC Collins, KD Janda Angewandte Chemie International Edition 55 (11), 3772-3775, 2016 | 151 | 2016 |
Dynamic vaccine blocks relapse to compulsive intake of heroin JE Schlosburg, LF Vendruscolo, PT Bremer, JW Lockner, CL Wade, ... Proceedings of the National Academy of Sciences 110 (22), 9036-9041, 2013 | 113 | 2013 |
Conjugate vaccine immunotherapy for substance use disorder PT Bremer, KD Janda Pharmacological reviews 69 (3), 298-315, 2017 | 103 | 2017 |
Development of a clinically viable heroin vaccine PT Bremer, JE Schlosburg, ML Banks, FF Steele, B Zhou, JL Poklis, ... Journal of the American Chemical Society 139 (25), 8601-8611, 2017 | 102 | 2017 |
Injection route and TLR9 agonist addition significantly impact heroin vaccine efficacy PT Bremer, JE Schlosburg, JM Lively, KD Janda Molecular pharmaceutics 11 (3), 1075-1080, 2014 | 88 | 2014 |
Rigid, sterically diverse n-heterocyclic carbene-pyridine chelates: Synthesis, mild palladation, and palladium-catalyzed allylic substitution AR Chianese, PT Bremer, C Wong, RJ Reynes Organometallics 28 (17), 5244-5252, 2009 | 62 | 2009 |
Conjugate vaccine produces long-lasting attenuation of fentanyl vs. food choice and blocks expression of opioid withdrawal-induced increases in fentanyl choice in rats EA Townsend, S Blake, KE Faunce, CS Hwang, Y Natori, B Zhou, ... Neuropsychopharmacology 44 (10), 1681-1689, 2019 | 58 | 2019 |
Monoclonal antibodies for combating synthetic opioid intoxication LC Smith, PT Bremer, CS Hwang, B Zhou, B Ellis, MS Hixon, KD Janda Journal of the American Chemical Society 141 (26), 10489-10503, 2019 | 57 | 2019 |
Enhancing efficacy and stability of an antiheroin vaccine: examination of antinociception, opioid binding profile, and lethality CS Hwang, PT Bremer, CJ Wenthur, SO Ho, SM Chiang, B Ellis, B Zhou, ... Molecular pharmaceutics 15 (3), 1062-1072, 2018 | 51 | 2018 |
Vaccine blunts fentanyl potency in male rhesus monkeys RD Tenney, S Blake, PT Bremer, B Zhou, CS Hwang, JL Poklis, KD Janda, ... Neuropharmacology 158, 107730, 2019 | 49 | 2019 |
Investigating the Effects of a Hydrolytically Stable Hapten and a Th1 Adjuvant on Heroin Vaccine Performance PT Bremer, KD Janda Journal of Medicinal Chemistry, 2012 | 49 | 2012 |
Methamphetamine vaccines: improvement through hapten design KC Collins, JE Schlosburg, PT Bremer, KD Janda Journal of medicinal chemistry 59 (8), 3878-3885, 2016 | 43 | 2016 |
Newly designed quinolinol inhibitors mitigate the effects of botulinum neurotoxin A in enzymatic, cell-based, and ex vivo assays PT Bremer, M Adler, CH Phung, AK Singh, KD Janda Journal of medicinal chemistry 60 (1), 338-348, 2017 | 42 | 2017 |
Functional Dissection of Pax3 in Paraxial Mesoderm Development and Myogenesis A Magli, E Schnettler, F Rinaldi, P Bremer, RCR Perlingeiro STEM CELLS, 2012 | 40 | 2012 |
Lipid tucaresol as an adjuvant for methamphetamine vaccine development KC Collins, JE Schlosburg, JW Lockner, PT Bremer, BA Ellis, KD Janda Chemical Communications 50 (31), 4079-4081, 2014 | 35 | 2014 |
Active vaccination attenuates the psychostimulant effects of α-PVP and MDPV in rats JD Nguyen, PT Bremer, A Ducime, KM Creehan, BR Kisby, MA Taffe, ... Neuropharmacology 116, 1-8, 2017 | 33 | 2017 |
Effective active vaccination against methamphetamine in female rats JD Nguyen, PT Bremer, CS Hwang, SA Vandewater, KC Collins, ... Drug and alcohol dependence 175, 179-186, 2017 | 31 | 2017 |
Effectiveness and selectivity of a heroin conjugate vaccine to attenuate heroin, 6-acetylmorphine, and morphine antinociception in rats: Comparison with naltrexone KL Schwienteck, S Blake, PT Bremer, JL Poklis, EA Townsend, SS Negus, ... Drug and alcohol dependence 204, 107501, 2019 | 28 | 2019 |
Metal ions effectively ablate the action of botulinum neurotoxin A PT Bremer, S Pellett, JP Carolan, WH Tepp, LM Eubanks, KN Allen, ... Journal of the American Chemical Society 139 (21), 7264-7272, 2017 | 27 | 2017 |