| Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction RC Hillig, B Sautier, J Schroeder, D Moosmayer, A Hilpmann, ... Proceedings of the National Academy of Sciences 116 (7), 2551-2560, 2019 | 323 | 2019 |
| The ATPase cycle of the mitochondrial Hsp90 analog Trap1 A Leskovar, H Wegele, ND Werbeck, J Buchner, J Reinstein Journal of biological chemistry 283 (17), 11677-11688, 2008 | 127 | 2008 |
| Coupling and dynamics of subunits in the hexameric AAA+ chaperone ClpB ND Werbeck, S Schlee, J Reinstein Journal of molecular biology 378 (1), 178-190, 2008 | 105 | 2008 |
| Probing a moving target with a plastic unfolding intermediate of an ankyrin-repeat protein ND Werbeck, LS Itzhaki Proceedings of the National Academy of Sciences 104 (19), 7863-7868, 2007 | 65 | 2007 |
| Disaggregases in 4 dimensions TRM Barends, ND Werbeck, J Reinstein Current opinion in structural biology 20 (1), 46-53, 2010 | 62 | 2010 |
| Shifting transition states in the unfolding of a large ankyrin repeat protein ND Werbeck, PJE Rowling, VR Chellamuthu, LS Itzhaki Proceedings of the National Academy of Sciences 105 (29), 9982-9987, 2008 | 50 | 2008 |
| Loop interactions and dynamics tune the enzymatic activity of the human histone deacetylase 8 MBA Kunze, DW Wright, ND Werbeck, J Kirkpatrick, PV Coveney, ... Journal of the American Chemical Society 135 (47), 17862-17868, 2013 | 46 | 2013 |
| Probing arginine side‐chains and their dynamics with carbon‐detected NMR spectroscopy: application to the 42 kDa human histone deacetylase 8 at high pH ND Werbeck, J Kirkpatrick, DF Hansen Angewandte Chemie 125 (11), 3227-3229, 2013 | 39 | 2013 |
| Characterization of the Menin-MLL interaction as therapeutic cancer target K Brzezinka, E Nevedomskaya, R Lesche, A Haegebarth, A Ter Laak, ... Cancers 12 (1), 201, 2020 | 32 | 2020 |
| Identification of small molecules that modulate mutant p53 condensation C Lemos, L Schulze, J Weiske, H Meyer, N Braeuer, N Barak, ... Iscience 23 (9), 2020 | 29 | 2020 |
| A distal regulatory region of a class I human histone deacetylase ND Werbeck, VK Shukla, MBA Kunze, H Yalinca, RB Pritchard, L Siemons, ... Nature communications 11 (1), 3841, 2020 | 26 | 2020 |
| Elements in nucleotide sensing and hydrolysis of the AAA+ disaggregation machine ClpB: a structure-based mechanistic dissection of a molecular motor C Zeymer, TRM Barends, ND Werbeck, I Schlichting, J Reinstein Acta Crystallographica Section D: Biological Crystallography 70 (2), 582-595, 2014 | 26 | 2014 |
| Using 15N‐Ammonium to Characterise and Map Potassium Binding Sites in Proteins by NMR Spectroscopy ND Werbeck, J Kirkpatrick, J Reinstein, DF Hansen ChemBioChem 15 (4), 543-548, 2014 | 25 | 2014 |
| Nucleotide binding and allosteric modulation of the second AAA+ domain of ClpB probed by transient kinetic studies ND Werbeck, JN Kellner, TRM Barends, J Reinstein Biochemistry 48 (30), 7240-7250, 2009 | 24 | 2009 |
| Characterizing active site conformational heterogeneity along the trajectory of an enzymatic phosphoryl transfer reaction C Zeymer, ND Werbeck, S Zimmermann, J Reinstein, DF Hansen Angewandte Chemie 128 (38), 11705-11709, 2016 | 23 | 2016 |
| The molecular mechanism of Hsp100 chaperone inhibition by the prion curing agent guanidinium chloride C Zeymer, ND Werbeck, I Schlichting, J Reinstein Journal of Biological Chemistry 288 (10), 7065-7076, 2013 | 21 | 2013 |
| Coupling of oligomerization and nucleotide binding in the AAA+ chaperone ClpB ND Werbeck, C Zeymer, JN Kellner, J Reinstein Biochemistry 50 (5), 899-909, 2011 | 18 | 2011 |
| Strategic Roles of Axial Histidines in Structure Formation and Redox Regulation of Tetraheme Cytochrome c3 Y Takayama, ND Werbeck, H Komori, K Morita, K Ozawa, Y Higuchi, ... Biochemistry 47 (36), 9405-9415, 2008 | 18 | 2008 |
| Heteronuclear transverse and longitudinal relaxation in AX4 spin systems: Application to 15N relaxations in 15NH4+ ND Werbeck, DF Hansen Journal of Magnetic Resonance 246, 136-148, 2014 | 8 | 2014 |
| Macrocyclic indole derivatives SAL Johannes, P Buchgraber, U Klar, C Christ, K Thede, J Kuhnke, ... US Patent 10,981,932, 2021 | 7 | 2021 |
