The lysosome as a cellular centre for signalling, metabolism and quality control RE Lawrence, R Zoncu Nature cell biology 21 (2), 133-142, 2019 | 688 | 2019 |
Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex RE Lawrence, SA Fromm, Y Fu, AL Yokom, DJ Kim, AM Thelen, ... Science 366 (6468), 971-977, 2019 | 121 | 2019 |
Hybrid structure of the RagA/C-Ragulator mTORC1 activation complex MY Su, KL Morris, Y Fu, R Lawrence, G Stjepanovic, R Zoncu, JH Hurley Molecular cell 68 (5), 835-846. e3, 2017 | 89 | 2017 |
A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase–Ragulator lysosomal scaffold RE Lawrence, KF Cho, R Rappold, A Thrun, M Tofaute, DJ Kim, ... Nature cell biology 20 (9), 1052-1063, 2018 | 88 | 2018 |
Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy LN Young, K Cho, R Lawrence, R Zoncu, JH Hurley Proceedings of the National Academy of Sciences 113 (29), 8224-8229, 2016 | 73 | 2016 |
eIF2B conformation and assembly state regulate the integrated stress response M Schoof, M Boone, L Wang, R Lawrence, A Frost, P Walter Elife 10, e65703, 2021 | 60 | 2021 |
Positive and negative regulation of the master metabolic regulator mTORC1 by two families of Legionella pneumophila effectors JA De Leon, J Qiu, CJ Nicolai, JL Counihan, KC Barry, L Xu, ... Cell reports 21 (8), 2031-2038, 2017 | 59 | 2017 |
Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9 SA Fromm, RE Lawrence, JH Hurley Nature structural & molecular biology 27 (11), 1017-1023, 2020 | 44 | 2020 |
PhotoGate microscopy to track single molecules in crowded environments V Belyy, SM Shih, J Bandaria, Y Huang, RE Lawrence, R Zoncu, A Yildiz Nature communications 8 (1), 13978, 2017 | 17 | 2017 |
The RootScope: a simple high-throughput screening system for quantitating gene expression dynamics in plant roots EJ Kast, MDT Nguyen, RE Lawrence, C Rabeler, NJ Kaplinsky BMC plant biology 13, 1-12, 2013 | 16 | 2013 |
Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B M Schoof, L Wang, JZ Cogan, RE Lawrence, M Boone, JD Wuerth, A Frost, ... Nature communications 12 (1), 7103, 2021 | 15 | 2021 |
A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation M Boone, L Wang, RE Lawrence, A Frost, P Walter, M Schoof Elife 11, e76171, 2022 | 6 | 2022 |
Arabidopsis Heat Shock Granules exhibit dynamic cellular behavior and can form in response to protein misfolding in the absence of elevated temperatures R Lawrence, N Kaplinsky Micropublication Biology 2020, 2020 | 3 | 2020 |
Viral evasion of the integrated stress response through antagonistic eIF2-P mimicry M Schoof, L Wang, J Zachery Cogan, R Lawrence, M Boone, JD Wuerth, ... bioRxiv, 2021.06. 07.447473, 2021 | 2 | 2021 |
Structural mechanism for amino acid-dependent Rag GTPase switching by SLC38A9 SA Fromm, RE Lawrence, JH Hurley bioRxiv, 2020.07. 28.225524, 2020 | 1 | 2020 |
A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling RE Lawrence, SR Shoemaker, A Deal, S Sangwan, AA Anand, L Wang, ... Nature Chemical Biology 20 (4), 422-431, 2024 | | 2024 |
A central helical switch controls integrated stress response signaling via eIF2B conformation and assembly R Lawrence, S Shoemaker, A Deal, L Wang, S Marqusee, P Walter Biophysical Journal 122 (3), 32a, 2023 | | 2023 |
A central helical fulcrum in eIF2B coordinates allosteric regulation of Integrated Stress Response signaling RE Lawrence, S Shoemaker, A Deal, S Sangwan, A Anand, L Wang, ... bioRxiv, 2022.12. 22.521453, 2022 | | 2022 |
Mechanisms of mTORC1 signal regulation by the Rag GTPases RE Lawrence University of California, Berkeley, 2019 | | 2019 |
Quantitative 4D tracking analysis and chemical induction of heat shock granules during cytosolic misfolded protein stress RE Lawrence | | 2012 |