Globally approved EGFR inhibitors: Insights into their syntheses, target kinases, biological activities, receptor interactions, and metabolism MAS Abourehab, AM Alqahtani, BGM Youssif, AM Gouda Molecules 26 (21), 6677, 2021 | 97 | 2021 |
A Comprehensive Overview of Globally Approved JAK Inhibitors AM Shawky, FA Almalki, AN Abdalla, AH Abdelazeem, AM Gouda pharmaceutics 14 (5), 10.3390/pharmaceutics14051001, 2022 | 94 | 2022 |
Design and synthesis of novel quinoline/chalcone/1, 2, 4-triazole hybrids as potent antiproliferative agent targeting EGFR and BRAFV600E kinases AM Mohassab, HA Hassan, D Abdelhamid, AM Gouda, BGM Youssif, ... Bioorganic chemistry 106, 104510, 2021 | 66 | 2021 |
Novel substituted and fused pyrrolizine derivatives: Synthesis, anti-inflammatory and ulcerogenecity studies SE Abbas, FM Awadallah, NA Ibrahim, AM Gouda European journal of medicinal chemistry 45 (2), 482-491, 2010 | 54 | 2010 |
Design and synthesis of novel 2, 3-dihydropyrazino [1, 2-a] indole-1, 4-dione derivatives as antiproliferative EGFR and BRAFV600E dual inhibitors LH Al-Wahaibi, AM Gouda, OF Abou-Ghadir, OIA Salem, AT Ali, ... Bioorganic Chemistry 104, 104260, 2020 | 52 | 2020 |
Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic antiproliferative activity FAM Mohamed, HAM Gomaa, OM Hendawy, AT Ali, HS Farghaly, ... Bioorganic Chemistry 112, 104960, 2021 | 50 | 2021 |
Antitumor activity of pyrrolizines and their Cu(II) complexes: Design, synthesis and cytotoxic screening with potential apoptosis-inducing activity AM Gouda, HA El-Ghamry, TM Bawazeer, TA Farghaly, AN Abdalla, ... European Journal of Medicinal Chemistry, 2018 | 50 | 2018 |
Antitumor activity of pyrrolizines and their Cu(II) complexes: Design, synthesis and cytotoxic screening with potential apoptosis-inducing activity AA Hoda A. El-Ghamry, Tahani M. Bawazeer, Thoraya A. Farghaly, Ashraf N. Abdalla European Journal of Medicinal Chemistry, 2018 | 50 | 2018 |
Optimization of pyrrolizine-based Schiff bases with 4-thiazolidinone motif: Design, synthesis and investigation of cytotoxicity and anti-inflammatory potency AM Shawky, MAS Abourehab, AN Abdalla, AM Gouda European journal of medicinal chemistry 185, 111780, 2020 | 49 | 2020 |
Design, synthesis and biological evaluation of novel diphenylthiazole-based cyclooxygenase inhibitors as potential anticancer agents MFT Ahmed H. Abdelazeem, Ahmed M. Gouda, Hany A. Omar journal of bioorganic chemistry 57, 132-141, 2014 | 49* | 2014 |
Design, synthesis and pharmacological evaluation of novel pyrrolizine derivatives as potential anticancer agents AM Gouda, AH Abdelazeem, ESA Arafa, KRA Abdellatif Bioorganic chemistry 53, 1-7, 2014 | 44 | 2014 |
Optimization and SAR investigation of novel 2, 3-dihydropyrazino [1, 2-a] indole-1, 4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and … HAM Gomaa, ME Shaker, SI Alzarea, OM Hendawy, FAM Mohamed, ... Bioorganic Chemistry 120, 105616, 2022 | 40 | 2022 |
Design and synthesis of new 1,6-dihydropyrimidin-2-thio derivatives targeting VEGFR-2: molecular docking and antiproliferative evaluation AA Marzouk, SA Abdel-Aziz, KS Abdelrahman, AS Wanas, AM Gouda, ... Bioorganic Chemistry, 2020 | 39 | 2020 |
Novel 1,2,4-triazole derivatives as apoptotic inducers targeting p53: synthesis and antiproliferative activity HAM Gomaa, HAM El-Sherief, S Hussein, AM Gouda, OIA Salem, ... Bioorganic Chemistry, 2020 | 37 | 2020 |
Design, synthesis and antitrypanosomal activity of heteroaryl-based 1, 2, 4-triazole and 1, 3, 4-oxadiazole derivatives MS Shaykoon, AA Marzouk, OM Soltan, AS Wanas, MM Radwan, ... Bioorganic chemistry 100, 103933, 2020 | 35 | 2020 |
Design, synthesis and biological evaluation of novel 5-((substituted quinolin-3-yl/1-naphthyl) methylene)-3-substituted imidazolidin-2, 4-dione as HIV-1 fusion inhibitors TS Ibrahim, RM Bokhtia, AMM Al-Mahmoudy, ES Taher, MA AlAwadh, ... Bioorganic Chemistry 99, 103782, 2020 | 35 | 2020 |
Design and synthesis of new triarylimidazole derivatives as dual inhibitors of BRAFV600E/p38α with potential antiproliferative activity BGM Youssif, AM Gouda, AH Moustafa, AA Abdelhamid, HAM Gomaa, ... Journal of Molecular Structure 1253, 132218, 2022 | 34 | 2022 |
An Integrated Overview on Pyrrolizines as Potential Anti-inflammatory, Analgesic and Antipyretic Agents AM Gouda, AH Abdelazeem EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016 | 33 | 2016 |
Arylpropionic acid-derived NSAIDs: New insights on derivatization, anticancer activity and potential mechanism of action AM Gouda, EA Beshr, FA Almalki, HH Halawah, BF Taj, AF Alnafaei, ... Bioorganic Chemistry 92, 103224, 2019 | 32 | 2019 |
Design, Synthesis, and Biological Evaluation of Some Novel Pyrrolizine Derivatives as COX Inhibitors with Anti-Inflammatory/Analgesic Activities and Low Ulcerogenic Liability MASAAHA Ahmed M. Gouda, Hamed I. Ali, Waleed H. Almalki, Mohamed A. Azim Molecules 21 (201), 2016 | 31 | 2016 |