متابعة
Hamada S. Abulkhair
Hamada S. Abulkhair
Professor of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University
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عنوان
عدد مرات الاقتباسات
عدد مرات الاقتباسات
السنة
Design, synthesis, molecular docking, and anticancer activity of benzoxazole derivatives as VEGFR‐2 inhibitors‏
AGA El‐Helby, H Sakr, IH Eissa, H Abulkhair, AA Al‐Karmalawy, K El‐Adl‏
Archiv der Pharmazie 352 (10), 1900113, 2019‏
1272019
Telaprevir is a potential drug for repurposing against SARS-CoV-2: computational and in vitro studies‏
A Mahmoud, A Mostafa, AA Al-Karmalawy, A Zidan, HS Abulkhair, ...‏
Heliyon 7 (9), 2021‏
772021
Computational insights on the potential of some NSAIDs for treating COVID-19: priority set and lead optimization‏
A Abo Elmaaty, MIA Hamed, MI Ismail, E B. Elkaeed, H S. Abulkhair, ...‏
Molecules 26 (12), 3772, 2021‏
692021
Discovery of new quinoxaline-2 (1H)-one-based anticancer agents targeting VEGFR-2 as inhibitors: Design, synthesis, and anti-proliferative evaluation‏
K El-Adl, HM Sakr, RG Yousef, ABM Mehany, AM Metwaly, ...‏
Bioorganic Chemistry 114, 105105, 2021‏
682021
New quinoxaline-2 (1 H)-ones as potential VEGFR-2 inhibitors: Design, synthesis, molecular docking, ADMET profile and anti-proliferative evaluations‏
RG Yousef, HM Sakr, IH Eissa, ABM Mehany, AM Metwaly, ...‏
New Journal of Chemistry 45 (36), 16949-16964, 2021‏
632021
From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity‏
MH El-Shershaby, A Ghiaty, AH Bayoumi, AA Al-Karmalawy, ...‏
Bioorganic & Medicinal Chemistry 42, 116266, 2021‏
582021
β-Blockers bearing hydroxyethylamine and hydroxyethylene as potential SARS-CoV-2 Mpro inhibitors: Rational based design, in silico, in vitro, and SAR studies for lead optimization‏
MIA Hamed, KM Darwish, R Soltane, A Chrouda, A Mostafa, NMA Shama, ...‏
RSC advances 11 (56), 35536-35558, 2021‏
542021
Design, synthesis, in silico ADMET profile and GABA‐A docking of novel phthalazines as potent anticonvulsants‏
AGA El‐Helby, RRA Ayyad, MF Zayed, HS Abulkhair, H Elkady, K El‐Adl‏
Archiv Der Pharmazie 352 (5), 1800387, 2019‏
542019
Design, synthesis, molecular docking, anticancer evaluations, and in silico pharmacokinetic studies of novel 5‐[(4‐chloro/2, 4‐dichloro) benzylidene] thiazolidine‐2, 4‐dione …‏
K El‐Adl, AGA El‐Helby, H Sakr, RR Ayyad, HA Mahdy, M Nasser, ...‏
Archiv der Pharmazie 354 (2), 2000279, 2021‏
532021
The antimicrobial potential and pharmacokinetic profiles of novel quinoline-based scaffolds: synthesis and in silico mechanistic studies as dual DNA gyrase and DHFR inhibitors‏
MH El-Shershaby, KM El-Gamal, AH Bayoumi, K El-Adl, M Alswah, ...‏
New Journal of Chemistry 45 (31), 13986-14004, 2021‏
522021
Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis‏
I Eid, MM Elsebaei, H Mohammad, M Hagras, CE Peters, YA Hegazy, ...‏
European journal of medicinal chemistry 139, 665-673, 2017‏
512017
Unravelling the anticancer potency of 1,2,4-triazole-N-arylamide hybrids through inhibition of STAT3: synthesis and in silico mechanistic studies‏
A Turky, AH Bayoumi, FF Sherbiny, K El-Adl, HS Abulkhair‏
Molecular diversity 25, 403-420, 2021‏
482021
Synthesis and antibacterial evaluation of a novel library of 2-(thiazol-5-yl)-1, 3, 4-oxadiazole derivatives against methicillin-resistant Staphylococcus aureus (MRSA)‏
MH Hannoun, M Hagras, A Kotb, AAMM El-Attar, HS Abulkhair‏
Bioorganic chemistry 94, 103364, 2020‏
472020
In vitro and computational investigations of novel synthetic carboxamide-linked pyridopyrrolopyrimidines with potent activity as SARS-CoV-2-M Pro inhibitors‏
A Aljuhani, HEA Ahmed, SK Ihmaid, AM Omar, SS Althagfan, ...‏
RSC advances 12 (41), 26895-26907, 2022‏
462022
Apoptosis induction, PARP-1 inhibition, and cell cycle analysis of leukemia cancer cells treated with novel synthetic 1, 2, 3-triazole-chalcone conjugates‏
EM Othman, EA Fayed, EM Husseiny, HS Abulkhair‏
Bioorganic Chemistry 123, 105762, 2022‏
452022
Synthesis, structural characterization, DFT calculations, molecular docking, and molecular dynamics simulations of a novel ferrocene derivative to unravel its potential …‏
MM Hammoud, M Khattab, M Abdel-Motaal, J Van der Eycken, R Alnajjar, ...‏
Journal of Biomolecular Structure and Dynamics 41 (11), 5199-5216, 2023‏
442023
Pharmacophore‐linked pyrazolo[3,4‐d]pyrimidines as EGFR‐TK inhibitors: Synthesis, anticancer evaluation, pharmacokinetics, and in silico mechanistic studies‏
AA Gaber, AM El‐Morsy, FF Sherbiny, AH Bayoumi, KM El‐Gamal, ...‏
Archiv Der Pharmazie, e2100258, 2021‏
442021
Novel triazolophthalazine-hydrazone hybrids as potential PCAF inhibitors: Design, synthesis, in vitro anticancer evaluation, apoptosis, and molecular docking studies‏
HS Abulkhair, A Turky, A Ghiaty, HEA Ahmed, AH Bayoumi‏
Bioorganic Chemistry 100, 103899, 2020‏
442020
Robust antiviral activity of commonly prescribed antidepressants against emerging coronaviruses: in vitro and in silico drug repurposing studies‏
O Kutkat, Y Moatasim, AA Al‐Karmalawy, HS Abulkhair, MR Gomaa, ...‏
Scientific Reports 12 (1), 12920, 2022‏
412022
Design, synthesis, and antitumor activity of novel compounds based on 1, 2, 4-triazolophthalazine scaffold: apoptosis-inductive and PCAF-inhibitory effects‏
A Turky, AH Bayoumi, A Ghiaty, AS El-Azab, AM Alaa, HS Abulkhair‏
Bioorganic Chemistry 101, 104019, 2020‏
412020
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مقالات 1–20