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Mr Louis Y Luk
Mr Louis Y Luk
University Research Fellow
Verified email at cardiff.ac.uk - Homepage
Title
Cited by
Cited by
Year
Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines
SG Patel, EJ Sayers, L He, R Narayan, TL Williams, EM Mills, ...
Scientific Reports 9 (1), 6298, 2019
1422019
Mechanistic studies on norcoclaurine synthase of benzylisoquinoline alkaloid biosynthesis: an enzymatic Pictet− Spengler reaction
LYP Luk, S Bunn, DK Liscombe, PJ Facchini, ME Tanner
Biochemistry 46 (35), 10153-10161, 2007
1372007
Unraveling the role of protein dynamics in dihydrofolate reductase catalysis
LYP Luk, J Javier Ruiz-Pernia, WM Dawson, M Roca, EJ Loveridge, ...
Proceedings of the National Academy of Sciences 110 (41), 16344-16349, 2013
1362013
A cope rearrangement in the reaction catalyzed by dimethylallyltryptophan synthase?
LYP Luk, Q Qian, ME Tanner
Journal of the American Chemical Society 133 (32), 12342-12345, 2011
852011
Mechanism of dimethylallyltryptophan synthase: evidence for a dimethylallyl cation intermediate in an aromatic prenyltransferase reaction
LYP Luk, ME Tanner
Journal of the American Chemical Society 131 (39), 13932-13933, 2009
732009
Using genetically incorporated unnatural amino acids to control protein functions in mammalian cells
AR Nödling, LA Spear, TL Williams, LYP Luk, YH Tsai
Essays in biochemistry 63 (2), 237-266, 2019
672019
Increased Dynamic Effects in a Catalytically Compromised Variant of Escherichia coli Dihydrofolate Reductase
JJ Ruiz-Pernia, LYP Luk, R García-Meseguer, S Martí, EJ Loveridge, ...
Journal of the American Chemical Society 135 (49), 18689-18696, 2013
632013
Protein motions and dynamic effects in enzyme catalysis
LYP Luk, EJ Loveridge, RK Allemann
Physical Chemistry Chemical Physics 17 (46), 30817-30827, 2015
512015
Condensation of 2-((alkylthio)(aryl) methylene) malononitrile with 1, 2-aminothiol as a novel bioorthogonal reaction for site-specific protein modification and peptide cyclization
X Zheng, Z Li, W Gao, X Meng, X Li, LYP Luk, Y Zhao, YH Tsai, C Wu
Journal of the American Chemical Society 142 (11), 5097-5103, 2020
372020
Reactivity and selectivity of iminium organocatalysis improved by a protein host
AR Nödling, K Świderek, R Castillo, JW Hall, A Angelastro, LC Morrill, ...
Angewandte Chemie 130 (38), 12658-12662, 2018
362018
Comparative biological evaluation and G-quadruplex interaction studies of two new families of organometallic gold (I) complexes featuring N-heterocyclic carbene and alkynyl ligands
SM Meier-Menches, B Aikman, D Döllerer, WT Klooster, SJ Coles, N Santi, ...
Journal of Inorganic Biochemistry 202, 110844, 2020
352020
Chemical ligation and isotope labeling to locate dynamic effects during catalysis by dihydrofolate reductase
LYP Luk, JJ Ruiz‐Pernía, AS Adesina, EJ Loveridge, I Tuñón, V Moliner, ...
Angewandte Chemie 127 (31), 9144-9148, 2015
352015
Protein Isotope Effects in Dihydrofolate Reductase From Geobacillus stearothermophilus Show Entropic–Enthalpic Compensatory Effects on the Rate Constant
LYP Luk, JJ Ruiz-Pernía, WM Dawson, EJ Loveridge, I Tuñón, V Moliner, ...
Journal of the American Chemical Society 136 (49), 17317-17323, 2014
332014
A Versatile Disulfide-Driven Recycling System for NADP+ with High Cofactor Turnover Number
A Angelastro, WM Dawson, LYP Luk, RK Allemann
ACS Catalysis 7 (2), 1025-1029, 2017
302017
Different dynamical effects in mesophilic and hyperthermophilic dihydrofolate reductases
LYP Luk, EJ Loveridge, RK Allemann
Journal of the American Chemical Society 136 (19), 6862-6865, 2014
292014
Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes
AR Nödling, EM Mills, X Li, D Cardella, EJ Sayers, SH Wu, AT Jones, ...
Chemical Communications 56 (34), 4672-4675, 2020
282020
Minimization of dynamic effects in the evolution of dihydrofolate reductase
JJ Ruiz-Pernía, E Behiry, LYP Luk, EJ Loveridge, I Tunón, V Moliner, ...
Chemical Science 7 (5), 3248-3255, 2016
262016
Thermal Adaptation of Dihydrofolate Reductase from the Moderate Thermophile Geobacillus stearothermophilus
J Guo, LYP Luk, EJ Loveridge, RK Allemann
Biochemistry 53 (17), 2855-2863, 2014
252014
Use of an asparaginyl endopeptidase for chemo-enzymatic peptide and protein labeling
TMS Tang, D Cardella, AJ Lander, X Li, JS Escudero, YH Tsai, LYP Luk
Chemical Science 11 (23), 5881-5888, 2020
232020
Site-specific His/Asp phosphoproteomic analysis of prokaryotes reveals putative targets for drug resistance
SJ Lai, IF Tu, WL Wu, JT Yang, LYP Luk, MC Lai, YH Tsai, SH Wu
BMC microbiology 17 (1), 1-10, 2017
222017
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