Sherif El-Khamisy
Sherif El-Khamisy
Director of the Genome Center, Zewail City of Science and Technology
No verified email - Homepage
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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-XL
J Zha, H Harada, E Yang, J Jockel, SJ Korsmeyer
Cell 87 (4), 619-628, 1996
A requirement for PARP‐1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage
SF El‐Khamisy, M Masutani, H Suzuki, KW Caldecott
Nucleic acids research 31 (19), 5526-5533, 2003
A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila
JW Pham, JL Pellino, YS Lee, RW Carthew, EJ Sontheimer
Cell 117 (1), 83-94, 2004
Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1
SF El-Khamisy, GM Saifi, M Weinfeld, F Johansson, T Helleday, JR Lupski, ...
Nature 434 (7029), 108-113, 2005
The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates
I Ahel, U Rass, SF El-Khamisy, S Katyal, PM Clements, PJ McKinnon, ...
Nature 443 (7112), 713-716, 2006
A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage
FC Ledesma, SF El Khamisy, MC Zuma, K Osborn, KW Caldecott
Nature 461 (7264), 674-678, 2009
The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks
JI Loizou, SF El-Khamisy, A Zlatanou, DJ Moore, DW Chan, J Qin, ...
Cell 117 (1), 17-28, 2004
TDP1 facilitates chromosomal single‐strand break repair in neurons and is neuroprotective in vivo
S Katyal, SF El‐Khamisy, HR Russell, Y Li, L Ju, KW Caldecott, ...
The EMBO journal 26 (22), 4720-4731, 2007
APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks
N Iles, S Rulten, SF El-Khamisy, KW Caldecott
Molecular and cellular biology 27 (10), 3793-3803, 2007
TDP2/TTRAP is the major 5′-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage
Z Zeng, F Cortés-Ledesma, SF El Khamisy, KW Caldecott
Journal of Biological Chemistry 286 (1), 403-409, 2011
Topoisomerase-mediated chromosomal break repair: an emerging player in many games
ME Ashour, R Atteya, SF El-Khamisy
Nature Reviews Cancer 15 (3), 137-151, 2015
TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function
F Gómez-Herreros, JHM Schuurs-Hoeijmakers, M McCormack, ...
Nature genetics 46 (5), 516-521, 2014
The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1
Y Lee, S Katyal, Y Li, SF El-Khamisy, HR Russell, KW Caldecott, ...
Nature neuroscience 12 (8), 973-980, 2009
C9orf72 expansion disrupts ATM-mediated chromosomal break repair
C Walker, S Herranz-Martin, E Karyka, C Liao, K Lewis, W Elsayed, ...
Nature neuroscience 20 (9), 1225-1235, 2017
Topoisomerase I inhibition in colorectal cancer: biomarkers and therapeutic targets
DC Gilbert, AJ Chalmers, SF El-Khamisy
British journal of cancer 106 (1), 18-24, 2012
Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin
SF El-Khamisy, S Katyal, P Patel, L Ju, PJ McKinnon, KW Caldecott
DNA repair 8 (6), 760-766, 2009
TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks
SF El-Khamisy, E Hartsuiker, KW Caldecott
DNA repair 6 (10), 1485-1495, 2007
SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits
GM Hautbergue, LM Castelli, L Ferraiuolo, A Sanchez-Martinez, ...
Nature communications 8 (1), 1-18, 2017
TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1
Z Zeng, A Sharma, L Ju, J Murai, L Umans, L Vermeire, Y Pommier, ...
Nucleic acids research 40 (17), 8371-8380, 2012
SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair
JJR Hudson, SC Chiang, OS Wells, C Rookyard, SF El-Khamisy
Nature communications 3 (1), 1-13, 2012
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