| A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ... Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017 | 219 | 2017 |
| Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein C Galvagnion, JWP Brown, MM Ouberai, P Flagmeier, M Vendruscolo, ... Proceedings of the National Academy of Sciences 113 (26), 7065-7070, 2016 | 206 | 2016 |
| Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation P Flagmeier, G Meisl, M Vendruscolo, TPJ Knowles, CM Dobson, ... Proceedings of the National Academy of Sciences 113 (37), 10328-10333, 2016 | 205 | 2016 |
| Protein microgels from amyloid fibril networks U Shimanovich, I Efimov, TO Mason, P Flagmeier, AK Buell, A Gedanken, ... ACS nano 9 (1), 43-51, 2015 | 111 | 2015 |
| Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, ... Nature communications 10 (1), 1-11, 2019 | 101 | 2019 |
| Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, ... Angewandte Chemie International Edition 56 (27), 7750-7754, 2017 | 83 | 2017 |
| Hsp70 inhibits the nucleation and elongation of tau and sequesters tau aggregates with high affinity F Kundel, S De, P Flagmeier, MH Horrocks, M Kjaergaard, SL Shammas, ... ACS chemical biology 13 (3), 636-646, 2018 | 73 | 2018 |
| β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces JWP Brown, AK Buell, TCT Michaels, G Meisl, J Carozza, P Flagmeier, ... Scientific reports 6 (1), 1-10, 2016 | 69 | 2016 |
| Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, ... ACS chemical biology 13 (8), 2308-2319, 2018 | 65 | 2018 |
| Mapping surface hydrophobicity of α-synuclein oligomers at the nanoscale JE Lee, JC Sang, M Rodrigues, AR Carr, MH Horrocks, S De, ... Nano letters 18 (12), 7494-7501, 2018 | 56 | 2018 |
| Single-molecule characterization of the interactions between extracellular chaperones and toxic α-synuclein oligomers DR Whiten, D Cox, MH Horrocks, CG Taylor, S De, P Flagmeier, L Tosatto, ... Cell reports 23 (12), 3492-3500, 2018 | 54 | 2018 |
| An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils ED Agerschou, P Flagmeier, T Saridaki, C Galvagnion, D Komnig, L Heid, ... Elife 8, e46112, 2019 | 42 | 2019 |
| Quantifying co-oligomer formation by α-synuclein M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, ... ACS nano 12 (11), 10855-10866, 2018 | 41 | 2018 |
| Optical Structural Analysis of Individual α‐Synuclein Oligomers JA Varela, M Rodrigues, S De, P Flagmeier, S Gandhi, CM Dobson, ... Angewandte Chemie 130 (18), 4980-4984, 2018 | 34 | 2018 |
| Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates S Chia, P Flagmeier, J Habchi, V Lattanzi, S Linse, CM Dobson, ... Proceedings of the National Academy of Sciences 114 (30), 8005-8010, 2017 | 34 | 2017 |
| Nanoscopic characterisation of individual endogenous protein aggregates in human neuronal cells DR Whiten, Y Zuo, L Calo, ML Choi, S De, P Flagmeier, DC Wirthensohn, ... ChemBioChem 19 (19), 2033-2038, 2018 | 32 | 2018 |
| Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation P Flagmeier, S De, TCT Michaels, X Yang, AJ Dear, C Emanuelsson, ... Nature Structural & Molecular Biology 27 (10), 886-891, 2020 | 25 | 2020 |
| The influence of pathogenic mutations in α-synuclein on biophysical and structural characteristics of amyloid fibrils FS Ruggeri, P Flagmeier, JR Kumita, G Meisl, DY Chirgadze, ... ACS nano 14 (5), 5213-5222, 2020 | 25 | 2020 |
| Inhibiting the Ca2+ influx induced by human CSF A Drews, S De, P Flagmeier, DC Wirthensohn, WH Chen, DR Whiten, ... Cell reports 21 (11), 3310-3316, 2017 | 20 | 2017 |
| Increased secondary nucleation underlies accelerated aggregation of the four-residue N-terminally truncated Aβ42 species Aβ5–42 T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, ... ACS chemical neuroscience 10 (5), 2374-2384, 2019 | 17 | 2019 |
Christopher DobsonUniversity of CambridgeVerified email at cam.ac.uk
