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Patrick Flagmeier
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A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ...
Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017
2192017
Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein
C Galvagnion, JWP Brown, MM Ouberai, P Flagmeier, M Vendruscolo, ...
Proceedings of the National Academy of Sciences 113 (26), 7065-7070, 2016
2062016
Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation
P Flagmeier, G Meisl, M Vendruscolo, TPJ Knowles, CM Dobson, ...
Proceedings of the National Academy of Sciences 113 (37), 10328-10333, 2016
2052016
Protein microgels from amyloid fibril networks
U Shimanovich, I Efimov, TO Mason, P Flagmeier, AK Buell, A Gedanken, ...
ACS nano 9 (1), 43-51, 2015
1112015
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, ...
Nature communications 10 (1), 1-11, 2019
1012019
Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, ...
Angewandte Chemie International Edition 56 (27), 7750-7754, 2017
832017
Hsp70 inhibits the nucleation and elongation of tau and sequesters tau aggregates with high affinity
F Kundel, S De, P Flagmeier, MH Horrocks, M Kjaergaard, SL Shammas, ...
ACS chemical biology 13 (3), 636-646, 2018
732018
β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces
JWP Brown, AK Buell, TCT Michaels, G Meisl, J Carozza, P Flagmeier, ...
Scientific reports 6 (1), 1-10, 2016
692016
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine
M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, ...
ACS chemical biology 13 (8), 2308-2319, 2018
652018
Mapping surface hydrophobicity of α-synuclein oligomers at the nanoscale
JE Lee, JC Sang, M Rodrigues, AR Carr, MH Horrocks, S De, ...
Nano letters 18 (12), 7494-7501, 2018
562018
Single-molecule characterization of the interactions between extracellular chaperones and toxic α-synuclein oligomers
DR Whiten, D Cox, MH Horrocks, CG Taylor, S De, P Flagmeier, L Tosatto, ...
Cell reports 23 (12), 3492-3500, 2018
542018
An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils
ED Agerschou, P Flagmeier, T Saridaki, C Galvagnion, D Komnig, L Heid, ...
Elife 8, e46112, 2019
422019
Quantifying co-oligomer formation by α-synuclein
M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, ...
ACS nano 12 (11), 10855-10866, 2018
412018
Optical Structural Analysis of Individual α‐Synuclein Oligomers
JA Varela, M Rodrigues, S De, P Flagmeier, S Gandhi, CM Dobson, ...
Angewandte Chemie 130 (18), 4980-4984, 2018
342018
Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates
S Chia, P Flagmeier, J Habchi, V Lattanzi, S Linse, CM Dobson, ...
Proceedings of the National Academy of Sciences 114 (30), 8005-8010, 2017
342017
Nanoscopic characterisation of individual endogenous protein aggregates in human neuronal cells
DR Whiten, Y Zuo, L Calo, ML Choi, S De, P Flagmeier, DC Wirthensohn, ...
ChemBioChem 19 (19), 2033-2038, 2018
322018
Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation
P Flagmeier, S De, TCT Michaels, X Yang, AJ Dear, C Emanuelsson, ...
Nature Structural & Molecular Biology 27 (10), 886-891, 2020
252020
The influence of pathogenic mutations in α-synuclein on biophysical and structural characteristics of amyloid fibrils
FS Ruggeri, P Flagmeier, JR Kumita, G Meisl, DY Chirgadze, ...
ACS nano 14 (5), 5213-5222, 2020
252020
Inhibiting the Ca2+ influx induced by human CSF
A Drews, S De, P Flagmeier, DC Wirthensohn, WH Chen, DR Whiten, ...
Cell reports 21 (11), 3310-3316, 2017
202017
Increased secondary nucleation underlies accelerated aggregation of the four-residue N-terminally truncated Aβ42 species Aβ5–42
T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, ...
ACS chemical neuroscience 10 (5), 2374-2384, 2019
172019
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