| Hypoxia-activated prodrugs: paths forward in the era of personalised medicine FW Hunter, BG Wouters, WR Wilson British journal of cancer 114 (10), 1071-1077, 2016 | 211 | 2016 |
| Mechanisms of resistance to trastuzumab emtansine (T-DM1) in HER2-positive breast cancer FW Hunter, HR Barker, B Lipert, F Rothé, G Gebhart, MJ Piccart-Gebhart, ... British journal of cancer 122 (5), 603-612, 2020 | 178 | 2020 |
| Identification of P450 oxidoreductase as a major determinant of sensitivity to hypoxia-activated prodrugs FW Hunter, RJ Young, Z Shalev, RN Vellanki, J Wang, Y Gu, N Joshi, ... Cancer Research 75 (19), 4211-4223, 2015 | 70 | 2015 |
| Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma SMF Jamieson, P Tsai, MK Kondratyev, P Budhani, A Liu, NN Senzer, ... JCI insight 3 (16), 2018 | 56 | 2018 |
| Dual targeting of hypoxia and homologous recombination repair dysfunction in triple-negative breast cancer FW Hunter, HL Hsu, J Su, SM Pullen, WR Wilson, J Wang Molecular cancer therapeutics 13 (11), 2501-2514, 2014 | 50 | 2014 |
| Homologous recombination repair-dependent cytotoxicity of the benzotriazine di-N-oxide CEN-209: comparison with other hypoxia-activated prodrugs FW Hunter, J Wang, R Patel, HL Hsu, AJR Hickey, MP Hay, WR Wilson Biochemical pharmacology 83 (5), 574-585, 2012 | 46 | 2012 |
| Cellular pharmacology of evofosfamide (TH-302): A critical re-evaluation of its bystander effects CR Hong, BD Dickson, JK Jaiswal, FB Pruijn, FW Hunter, MP Hay, ... Biochemical pharmacology 156, 265-280, 2018 | 31 | 2018 |
| Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery M Hunter, KJ Spiller, MA Dominique, H Xu, FW Hunter, TC Fang, ... Acta Neuropathologica Communications 9, 1-19, 2021 | 29 | 2021 |
| Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia TW Lee, WW Wong, BD Dickson, B Lipert, GJ Cheng, FW Hunter, MP Hay, ... International journal of radiation biology 95 (12), 1597-1612, 2019 | 29 | 2019 |
| The flavoprotein FOXRED2 reductively activates nitro-chloromethylbenzindolines and other hypoxia-targeting prodrugs FW Hunter, JK Jaiswal, DG Hurley, HDS Liyanage, SP McManaway, Y Gu, ... Biochemical Pharmacology 89 (2), 224-235, 2014 | 24 | 2014 |
| Hypoxia-selective radiosensitisation by SN38023, a bioreductive prodrug of DNA-dependent protein kinase inhibitor IC87361 WW Wong, RK Jackson, LP Liew, BD Dickson, GJ Cheng, B Lipert, Y Gu, ... Biochemical pharmacology 169, 113641, 2019 | 22 | 2019 |
| Impact of tumour hypoxia on evofosfamide sensitivity in head and neck squamous cell carcinoma patient-derived xenograft models JK Harms, TW Lee, T Wang, A Lai, D Kee, JM Chaplin, NP McIvor, ... Cells 8 (7), 717, 2019 | 19 | 2019 |
| Print CG, Wilson WR, Pruijn FB (2014) The flavoprotein FOXRED2 reductively activates nitro-chloromethylbenzindolines and other hypoxiatargeting prodrugs FW Hunter, JK Jaiswal, DG Hurley, HD Liyanage, SP McManaway, Y Gu, ... Biochem Pharmacol 89, 224-235, 0 | 16 | |
| Functional CRISPR and shRNA screens identify involvement of mitochondrial electron transport in the activation of evofosfamide FW Hunter, JBL Devaux, F Meng, CR Hong, A Khan, P Tsai, TW Ketela, ... Molecular pharmacology 95 (6), 638-651, 2019 | 14 | 2019 |
| Antagonism in effectiveness of evofosfamide and doxorubicin through intermolecular electron transfer RF Anderson, D Li, FW Hunter Free Radical Biology and Medicine 113, 564-570, 2017 | 14 | 2017 |
| Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma SMF Jamieson, P Tsai, MK Kondratyev, P Budhani, A Liu, NN Senzer, ... JCI insight 8 (4), 2023 | 2 | 2023 |
| Development of capability for genome-scale CRISPR-Cas9 knockout screens in New Zealand FW Hunter, P Tsai, PM Kakadia, SK Bohlander, CG Print, WR Wilson Journal of the Royal Society of New Zealand 48 (4), 245-261, 2018 | 2 | 2018 |
| 412P Effects of statins on melanoma KB Tran, S Kolekar, SMF Jamieson, FW Hunter, A Jabed, D Li, WR Wilson, ... Annals of Oncology 27, ix128, 2016 | 2 | 2016 |
| Random clonal expansion as a limiting factor in transplantable in vivo CRISPR/Cas9 screens TW Lee, FW Hunter, WR Wilson, SMF Jamieson bioRxiv, 2021.11. 28.469740, 2021 | 1 | 2021 |
| Identification of TSC1 and TSC2 as potential determinants of sensitivity to trastuzumab emtansine FW Hunter, BA Lipert, KN Siemens, A Khan, HR Barker, TW Ketela, ... Cancer Research 80 (16_Supplement), 5853-5853, 2020 | 1 | 2020 |
Bradly WoutersPrincess Margaret Cancer Centre, University Health Network, University of TorontoVerified email at uhnresearch.ca
