Rosmarie Friemann
Rosmarie Friemann
Researcher, Sahlgrenska University Hospital, University of Gothenburg
Verified email at
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Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation
A Talavera, R Friemann, S Gómez-Puerta, C Martinez-Fleites, G Garrido, ...
Cancer research 69 (14), 5851-5859, 2009
Subangstrom resolution X-ray structure details aquaporin-water interactions
U Kosinska Eriksson, G Fischer, R Friemann, G Enkavi, E Tajkhorshid, ...
science 340 (6138), 1346-1349, 2013
Crystal structure of plant pectin methylesterase
K Johansson, M El-Ahmad, R Friemann, H Jörnvall, O Markovič, H Eklund
Febs Letters 514 (2-3), 243-249, 2002
Structural snapshots along the reaction pathway of ferredoxin–thioredoxin reductase
S Dai, R Friemann, DA Glauser, F Bourquin, W Manieri, P Schürmann, ...
Nature 448 (7149), 92-96, 2007
Structural insight into the dioxygenation of nitroarene compounds: the crystal structure of nitrobenzene dioxygenase
R Friemann, MM Ivkovic-Jensen, DJ Lessner, CL Yu, DT Gibson, ...
Journal of molecular biology 348 (5), 1139-1151, 2005
Transcription factor clusters regulate genes in eukaryotic cells
AJM Wollman, S Shashkova, EG Hedlund, R Friemann, S Hohmann, ...
Elife 6, e27451, 2017
Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site
WY Wahlgren, E Dunevall, RA North, A Paz, M Scalise, P Bisignano, ...
Nature Communications 9 (1), 1753, 2018
Structures of the multicomponent Rieske non-heme iron toluene 2, 3-dioxygenase enzyme system
R Friemann, K Lee, EN Brown, DT Gibson, H Eklund, S Ramaswamy
Acta Crystallographica Section D: Biological Crystallography 65 (1), 24-33, 2009
Determining Rieske cluster reduction potentials
EN Brown, R Friemann, A Karlsson, JV Parales, MMJ Couture, LD Eltis, ...
JBIC Journal of Biological Inorganic Chemistry 13, 1301-1313, 2008
Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors
S Sainas, AC Pippione, E Lupino, M Giorgis, P Circosta, V Gaidano, ...
Journal of medicinal chemistry 61 (14), 6034-6055, 2018
Purification, characterization, and crystallization of the components of the nitrobenzene and 2-nitrotoluene dioxygenase enzyme systems
RE Parales, R Huang, CL Yu, JV Parales, FKN Lee, DJ Lessner, ...
Applied and environmental microbiology 71 (7), 3806-3814, 2005
Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds
S Sainas, AC Pippione, M Giorgis, E Lupino, P Goyal, C Ramondetti, ...
European Journal of Medicinal Chemistry 129, 287-302, 2017
Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid
AC Pippione, IM Carnovale, D Bonanni, M Sini, P Goyal, E Marini, K Pors, ...
European Journal of Medicinal Chemistry 150, 930-945, 2018
Inhibitor binding mode and allosteric regulation of Na+-glucose symporters
P Bisignano, C Ghezzi, H Jo, NF Polizzi, T Althoff, C Kalyanaraman, ...
Nature communications 9 (1), 5245, 2018
Molecular dynamics simulations of a membrane protein− micelle complex in vacuo
R Friemann, DSD Larsson, Y Wang, D van der Spoel
Journal of the American Chemical Society 131 (46), 16606-16607, 2009
“Just a spoonful of sugar...”: import of sialic acid across bacterial cell membranes
RA North, CR Horne, JS Davies, DM Remus, AC Muscroft-Taylor, P Goyal, ...
Biophysical Reviews 10, 219-227, 2018
Active site residues controlling substrate specificity in 2-nitrotoluene dioxygenase from Acidovorax sp. strain JS42
KS Lee, JV Parales, R Friemann, RE Parales
Journal of Industrial Microbiology and Biotechnology 32 (10), 465-473, 2005
Bioisosteres of indomethacin as inhibitors of aldo-keto reductase 1C3
ML Lolli, IM Carnovale, AC Pippione, WY Wahlgren, D Bonanni, E Marini, ...
ACS medicinal chemistry letters 10 (4), 437-443, 2019
Structure of thioredoxin from Trypanosoma brucei brucei
R Friemann, H Schmidt, S Ramaswamy, M Forstner, RL Krauth-Siegel, ...
FEBS letters 554 (3), 301-305, 2003
Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies
AC Pippione, S Sainas, P Goyal, I Fritzson, GC Cassiano, A Giraudo, ...
European journal of medicinal chemistry 163, 266-280, 2019
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