| AIDS-driven nucleoside chemistry. DM Huryn, M Okabe Chemical reviews 92 (8), 1745-1768, 1992 | 720 | 1992 |
| Carboxylic acid (bio) isosteres in drug design C Ballatore, DM Huryn, AB Smith III ChemMedChem 8 (3), 385-395, 2013 | 550 | 2013 |
| 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition S Banerjee, A Bartesaghi, A Merk, P Rao, SL Bulfer, Y Yan, N Green, ... Science 351 (6275), 871-875, 2016 | 369 | 2016 |
| Microtubule stabilizing agents as potential treatment for Alzheimer’s disease and related neurodegenerative tauopathies C Ballatore, KR Brunden, DM Huryn, JQ Trojanowski, VMY Lee, ... American Chemical Society, 2012 | 253 | 2012 |
| Structure property relationships of carboxylic acid isosteres P Lassalas, B Gay, C Lasfargeas, MJ James, V Tran, KG Vijayendran, ... Journal of medicinal chemistry 59 (7), 3183-3203, 2016 | 238 | 2016 |
| Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein γ-secretase for the treatment of Alzheimer's disease RL Martone, H Zhou, K Atchison, T Comery, JZ Xu, X Huang, X Gong, ... Journal of Pharmacology and Experimental Therapeutics 331 (2), 598-608, 2009 | 193 | 2009 |
| Optimization of a higher throughput microsomal stability screening assay for profiling drug discovery candidates L Di, EH Kerns, Y Hong, TA Kleintop, OJ Mc Connell, DM Huryn SLAS Discovery 8 (4), 453-462, 2003 | 169 | 2003 |
| Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum AN Chiang, JC Valderramos, R Balachandran, RJ Chovatiya, BP Mead, ... Bioorganic & medicinal chemistry 17 (4), 1527-1533, 2009 | 166 | 2009 |
| Discovery of begacestat, a Notch-1-sparing γ-secretase inhibitor for the treatment of Alzheimer’s disease SC Mayer, AF Kreft, B Harrison, M Abou-Gharbia, M Antane, S Aschmies, ... Journal of medicinal chemistry 51 (23), 7348-7351, 2008 | 146 | 2008 |
| A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells PP Shah, T Wang, RL Kaletsky, MC Myers, JE Purvis, H Jing, DM Huryn, ... Molecular pharmacology 78 (2), 319-324, 2010 | 135 | 2010 |
| Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation CM Wright, RJ Chovatiya, NE Jameson, DM Turner, G Zhu, S Werner, ... Bioorganic & medicinal chemistry 16 (6), 3291-3301, 2008 | 120 | 2008 |
| HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus PA Johnston, J Phillips, TY Shun, S Shinde, JS Lazo, DM Huryn, ... Assay and drug development technologies 5 (6), 737-750, 2007 | 119 | 2007 |
| Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening A Crowe, W Huang, C Ballatore, RL Johnson, AML Hogan, R Huang, ... Biochemistry 48 (32), 7732-7745, 2009 | 118 | 2009 |
| Ferroptosis as a novel therapeutic target for Friedreich’s ataxia MG Cotticelli, S Xia, D Lin, T Lee, L Terrab, P Wipf, DM Huryn, RB Wilson Journal of Pharmacology and Experimental Therapeutics 369 (1), 47-54, 2019 | 109 | 2019 |
| Identification of novel inhibitors of dietary lipid absorption using zebrafish JD Clifton, E Lucumi, MC Myers, A Napper, K Hama, SA Farber, ... PloS one 5 (8), e12386, 2010 | 98 | 2010 |
| Experimental design on single-time-point high-throughput microsomal stability assay L Di, EH Kerns, N Gao, SQ Li, Y Huang, JL Bourassa, DM Huryn Journal of pharmaceutical sciences 93 (6), 1537-1544, 2004 | 91 | 2004 |
| Synthesis of iso-ddA, member of a novel class of anti-HIV agents DM Huryn, BC Sluboski, SY Tam, LJ Todaro, M Weigele Tetrahedron letters 30 (46), 6259-6262, 1989 | 89 | 1989 |
| Pharmaceutical profiling method for lipophilicity and integrity using liquid chromatography–mass spectrometry EH Kerns, L Di, S Petusky, T Kleintop, D Huryn, O McConnell, G Carter Journal of Chromatography B 791 (1-2), 381-388, 2003 | 86 | 2003 |
| p97: an emerging target for cancer, neurodegenerative diseases, and viral infections DM Huryn, DJP Kornfilt, P Wipf Journal of medicinal chemistry 63 (5), 1892-1907, 2019 | 85 | 2019 |
| Microtubule-stabilising drugs for therapy of Alzheimer’s disease and other neurodegenerative disorders with axonal transport impairments JQ Trojanowski, AB Smith, D Huryn, VMY Lee Expert opinion on pharmacotherapy 6 (5), 683-686, 2005 | 82 | 2005 |
