Novel pyrazolopyrimidine derivatives targeting COXs and iNOS enzymes; design, synthesis and biological evaluation as potential anti-inflammatory agents AH Abdelazeem, SA Abdelatef, MT El-Saadi, HA Omar, SI Khan, ... European Journal of Pharmaceutical Sciences 62, 197-211, 2014 | 80 | 2014 |
Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines MT Elsaadi Bioorganic and medicinal chemistry 24, 2016 | 60 | 2016 |
Design, synthesis and analgesic/anti-inflammatory evaluation of novel diarylthiazole and diarylimidazole derivatives towards selective COX-1 inhibitors with better gastric profile AH Abdelazeem, MT El-Saadi, AGS El-Din, HA Omar, SM El-Moghazy Bioorganic & medicinal chemistry 25 (2), 665-676, 2017 | 45 | 2017 |
Novel diphenylthiazole derivatives with multi-target mechanism: Synthesis, docking study, anticancer and anti-inflammatory activities AH Abdelazeem, MT El-Saadi, EG Said, BGM Youssif, HA Omar, ... Bioorganic Chemistry 75, 127-138, 2017 | 44 | 2017 |
Design, synthesis and anticancer evaluation of novel spirobenzo [h] chromene and spirochromane derivatives with dual EGFR and B-RAF inhibitory activities SA Abdelatef, MT El-Saadi, NH Amin, AH Abdelazeem, HA Omar, ... European journal of medicinal chemistry 150, 567-578, 2018 | 42 | 2018 |
Design, synthesis and mechanistic study of new 1, 2, 4-triazole derivatives as antimicrobial agents NH Amin, MT El-Saadi, AA Ibrahim, HM Abdel-Rahman Bioorganic chemistry 111, 104841, 2021 | 41 | 2021 |
Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS KRA Abdellatif, A Belal, MT El-Saadi, NH Amin, EG Said, LR Hemeda Bioorganic Chemistry 101, 103976, 2020 | 37 | 2020 |
Synthesis, anti-inflammatory and ulcerogenicity studies of some substituted pyrimido [1, 6-a] azepine derivatives NA El-Sayed, FM Awadallah, NA Ibrahim, MT El-Saadi European journal of medicinal chemistry 45 (7), 3147-3154, 2010 | 34 | 2010 |
Synthesis, cyclooxygenase inhibition and anti-inflammatory evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing methanesulphonyl … KRA Abdellatif, MT Elsaady, SA Abdel-Aziz, AHA Abusabaa Journal of enzyme inhibition and medicinal chemistry 31 (6), 1545-1555, 2016 | 29 | 2016 |
Discovery of novel urea-diarylpyrazole hybrids as dual COX-2/sEH inhibitors with improved anti-inflammatory activity and highly reduced cardiovascular risks AH Abdelazeem, AGS El-Din, MM Abdel-Fattah, NH Amin, ... European Journal of Medicinal Chemistry 205, 112662, 2020 | 26 | 2020 |
Design, synthesis, biological assessment, and in-silico studies of 1, 2, 4-triazolo [1, 5-a] pyrimidine derivatives as tubulin polymerization inhibitors HS Mohamed, NH Amin, MT El-Saadi, HM Abdel-Rahman Bioorganic Chemistry 121, 105687, 2022 | 19 | 2022 |
Anti-inflammatory indomethacin analogs endowed with preferential COX-2 inhibitory activity NH Amin, MT El-Saadi, AA Hefny, AH Abdelazeem, HAH Elshemy, ... Future medicinal chemistry 10 (21), 2521-2535, 2018 | 18 | 2018 |
Experimentally designed chromatographic method for the simultaneous analysis of dimenhydrinate, cinnarizine and their toxic impurities. MT AlSaadi Royal society of chemistry advances 11, 1450 -1460, 0 | 13* | |
Design, synthesis and biological evaluation of new imidazo [1, 2-a] pyridine derivatives as selective COX-2 inhibitors AS Ismael, NH Amin, MT Elsaadi, MRA Ali, HM Abdel-Rahman Journal of Molecular Structure 1250, 131652, 2022 | 12 | 2022 |
Synthesis And Anticancer Screening Of Novel Spiro [Chroman-2, 4′-Piperidin]-4-One Derivatives With Apoptosis-Inducing Activity SA Abdelatef, MT El-Saadi, NH Amin, AH Abdelazeem, KRA Abdellatif Journal of Applied Pharmaceutical Science 8 (1), 009-016, 2018 | 12 | 2018 |
Different Spectrophotometric and TLC-Densitometric Methods for Determination of Mesalazine in Presence of Its Two Toxic Impurities MTE Martha M.Morcoss, Nada S.Abdelwahab, Nourddin W.Ali Chemical and pharmaceutical bulletin 64, 2016 | 11 | 2016 |
Design, synthesis and anti-inflammatory/analgesic evaluation of novel di-substituted urea derivatives bearing diaryl-1, 2, 4-triazole with dual COX-2/sEH inhibitory activities AH Abdelazeem, AGS El-Din, HH Arab, MT El-Saadi, SM El-Moghazy, ... Journal of Molecular Structure 1240, 130565, 2021 | 10 | 2021 |
Five spectrophotometric methods for simultaneous determination of Amlodipine besylate and celecoxib in presence of its toxic impurity MMZ Sharkawi, NR Mohamed, MT El-Saadi, NH Amin Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 263, 120137, 2021 | 8 | 2021 |
Comparison of two augmented classical least squares algorithms and PLS for determining nifuroxazide and its genotoxic impurities using UV spectroscopy MA Hegazy, NS Abdelwahab, NW Ali, MMZ Sharkawi, MM Abdelkawy, ... Journal of Chemometrics 33 (12), e3190, 2019 | 8 | 2019 |
New substituted pyrazole derivatives targeting COXs as potential safe anti-inflammatory agents KRA Abdellatif, MT El-Saadi, SG Elzayat, NH Amin Future Medicinal Chemistry 11 (16), 1871-1882, 2019 | 8 | 2019 |