Membrane transporters in drug development Nature reviews Drug discovery 9 (3), 215-236, 2010 | 3615 | 2010 |
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action Y Shu, SA Sheardown, C Brown, RP Owen, S Zhang, RA Castro, ... The Journal of clinical investigation 117 (5), 1422-1431, 2007 | 1110 | 2007 |
SLC transporters as therapeutic targets: emerging opportunities L Lin, SW Yee, RB Kim, KM Giacomini Nature reviews Drug discovery 14 (8), 543-560, 2015 | 861 | 2015 |
Metformin pathways: pharmacokinetics and pharmacodynamics L Gong, S Goswami, KM Giacomini, RB Altman, TE Klein Pharmacogenetics and genomics 22 (11), 820-827, 2012 | 627 | 2012 |
Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics Y Shu, C Brown, RA Castro, RJ Shi, ET Lin, RP Owen, SA Sheardown, ... Clinical pharmacology & therapeutics 83 (2), 273-280, 2008 | 563 | 2008 |
Organic cation transporters are determinants of oxaliplatin cytotoxicity S Zhang, KS Lovejoy, JE Shima, LL Lagpacan, Y Shu, A Lapuk, Y Chen, ... Cancer research 66 (17), 8847-8857, 2006 | 539 | 2006 |
The concentrative nucleoside transporter family, SLC28 JH Gray, RP Owen, KM Giacomini Pflügers Archiv 447, 728-734, 2004 | 525 | 2004 |
Cloning and functional expression of a human liver organic cation transporter L Zhang, MJ Dresser, AT Gray, SC Yost, S Terashita, KM Giacomini Molecular pharmacology 51 (6), 913-921, 1997 | 511 | 1997 |
Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene DL Kroetz, C Pauli-Magnus, LM Hodges, CC Huang, M Kawamoto, ... Pharmacogenetics and Genomics 13 (8), 481-494, 2003 | 506 | 2003 |
Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges RA Wilke, DW Lin, DM Roden, PB Watkins, D Flockhart, I Zineh, ... Nature reviews Drug discovery 6 (11), 904-916, 2007 | 477 | 2007 |
Emerging transporters of clinical importance: an update from the International Transporter Consortium KM Hillgren, D Keppler, AA Zur, KM Giacomini, B Stieger, CE Cass, ... Clinical Pharmacology & Therapeutics 94 (1), 52-63, 2013 | 407 | 2013 |
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects LR Treviño, N Shimasaki, W Yang, JC Panetta, C Cheng, D Pei, D Chan, ... Journal of Clinical Oncology 27 (35), 5972-5978, 2009 | 396 | 2009 |
When good drugs go bad KM Giacomini, RM Krauss, DM Roden, M Eichelbaum, MR Hayden, ... Nature 446 (7139), 975-977, 2007 | 358 | 2007 |
Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters MJ Dresser, MK Leabman, KM Giacomini Journal of pharmaceutical sciences 90 (4), 397-421, 2001 | 355 | 2001 |
Renal transporters in drug development KM Morrissey, SL Stocker, MB Wittwer, L Xu, KM Giacomini Annual review of pharmacology and toxicology 53 (1), 503-529, 2013 | 344 | 2013 |
Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1 Y Shu, MK Leabman, B Feng, LM Mangravite, CC Huang, D Stryke, ... Proceedings of the National Academy of Sciences 100 (10), 5902-5907, 2003 | 344 | 2003 |
Pharmacogenomics: challenges and opportunities DM Roden, RB Altman, NL Benowitz, DA Flockhart, KM Giacomini, ... Annals of internal medicine 145 (10), 749-757, 2006 | 315 | 2006 |
The pharmacogenetics research network: from SNP discovery to clinical drug response KM Giacomini, CM Brett, RB Altman, NL Benowitz, ME Dolan, ... Clinical Pharmacology & Therapeutics 81 (3), 328-345, 2007 | 311 | 2007 |
Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition LB Ramsey, GH Bruun, W Yang, LR Treviño, S Vattathil, P Scheet, ... Genome research 22 (1), 1-8, 2012 | 301 | 2012 |
Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin Y Chen, S Li, C Brown, S Cheatham, RA Castro, MK Leabman, TJ Urban, ... Pharmacogenetics and genomics 19 (7), 497-504, 2009 | 292 | 2009 |