David Lutje Hulsik
David Lutje Hulsik
LAVA Therapeutics NV
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Isolation of llama antibody fragments for prevention of dandruff by phage display in shampoo
E Dolk, M Van Der Vaart, D Lutje Hulsik, G Vriend, H de Haard, S Spinelli, ...
Applied and environmental microbiology 71 (1), 442-450, 2005
Charged multivesicular body protein 2B (CHMP2B) of the endosomal sorting complex required for transport-III (ESCRT-III) polymerizes into helical structures deforming the plasma …
G Bodon, R Chassefeyre, K Pernet-Gallay, N Martinelli, G Effantin, ...
Journal of Biological Chemistry 286 (46), 40276-40286, 2011
Crystal structure and size-dependent neutralization properties of HK20, a human monoclonal antibody binding to the highly conserved heptad repeat 1 of gp41
C Sabin, D Corti, V Buzon, MS Seaman, D Lutje Hulsik, A Hinz, ...
PLoS pathogens 6 (11), e1001195, 2010
A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition
D Lutje Hulsik, Y Liu, NM Strokappe, S Battella, M El Khattabi, LE McCoy, ...
PLoS pathogens 9 (3), e1003202, 2013
Llama antibody fragments recognizing various epitopes of the CD4bs neutralize a broad range of HIV-1 subtypes A, B and C
N Strokappe, A Szynol, M Aasa-Chapman, A Gorlani, A Forsman Quigley, ...
PloS one 7 (3), e33298, 2012
Heavier-than-air flying machines are impossible
L Oliveira, T Hulsen, DL Hulsik, ACM Paiva, G Vriend
FEBS letters 564 (3), 269-273, 2004
Structural basis for ESCRT-III CHMP3 recruitment of AMSH
J Solomons, C Sabin, E Poudevigne, Y Usami, DL Hulsik, P Macheboeuf, ...
Structure 19 (8), 1149-1159, 2011
Crystal Structure of the Neutralizing Llama VHH D7 and Its Mode of HIV-1 gp120 Interaction
A Hinz, D Lutje Hulsik, A Forsman, WWL Koh, H Belrhali, A Gorlani, ...
PloS one 5 (5), e10482, 2010
Characterization of a trimeric MPER containing HIV-1 gp41 antigen
A Hinz, G Schoehn, H Quendler, DL Hulsik, G Stiegler, H Katinger, ...
Virology 390 (2), 221-227, 2009
A fusion intermediate gp41 immunogen elicits neutralizing antibodies to HIV-1
RPJ Lai, M Hock, J Radzimanowski, P Tonks, DL Hulsik, G Effantin, ...
Journal of Biological Chemistry 289 (43), 29912-29926, 2014
Functional characterization of the selective pan-allele anti-SIRPα antibody ADU-1805 that blocks the SIRPα–CD47 innate immune checkpoint
E Voets, M Paradé, D Lutje Hulsik, S Spijkers, W Janssen, J Rens, ...
Journal for immunotherapy of cancer 7 (1), 1-15, 2019
Calpain 3 is a rapid-action, unidirectional proteolytic switch central to muscle remodeling
A De Morrée, D Lutje Hulsik, A Impagliazzo, HH van Haagen, P de Galan, ...
PLoS One 5 (8), e11940, 2010
Antibody engineering reveals the important role of J segments in the production efficiency of llama single-domain antibodies in Saccharomyces cerevisiae
A Gorlani, D Lutje Hulsik, H Adams, G Vriend, P Hermans, T Verrips
Protein Engineering, Design & Selection 25 (1), 39-46, 2012
Altered APRIL binding antibodies
H Van Eenennaam, A Van Elsas, DL Hulsik, JP Medema
US Patent 9,969,808, 2018
A novel efficient bispecific antibody format, combining a conventional antigen-binding fragment with a single domain antibody, avoids potential heavy-light chain mis-pairing
S Huang, A Segués, DL Hulsik, DM Zaiss, AJAM Sijts, ...
Journal of immunological methods 483, 112811, 2020
Method of treating IgA nephropathy by administering humanized APRIL-binding antibodies
H Van Eenennaam, A Van Elsas, DL Hulsik, JP Medema
US Patent 10,377,830, 2019
Anti-PD-1 antibodies
H Van Eenennaam, A Van Elsas, J Kreijtz, DL Hulsik, CRR Dos Reis
US Patent 10,494,436, 2019
Improving properties of llama heavy chain antibodies using in silico analysis
D Lutje Hulsik
Utrecht University, 2009
Anti-SIRPα antibodies
H Van Eenennaam, A Van Elsas, E Voets, V Paul, DL Hulsik
US Patent 10,851,164, 2020
Development of a first in class APRIL fully blocking antibody BION-1301 for the treatment of multiple myeloma
J Dulos, L Driessen, M Snippert, M Guadagnoli, A Bertens, DL Hulsik, ...
Cancer Research 77 (13_Supplement), 2645-2645, 2017
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