| Droplet Microfluidics Platform for Highly Sensitive and Quantitative Detection of Malaria-Causing Plasmodium Parasites Based on Enzyme Activity Measurement S Juul, CJF Nielsen, R Labouriau, A Roy, C Tesauro, PW Jensen, ... ACS nano 6 (12), 10676-10683, 2012 | 98 | 2012 |
| Novel topoisomerase I inhibitors. Syntheses and biological evaluation of phosphorus substituted quinoline derivates with antiproliferative activity C Alonso, M Fuertes, E Martín-Encinas, A Selas, G Rubiales, C Tesauro, ... European Journal of Medicinal Chemistry 149, 225-237, 2018 | 68 | 2018 |
| Interaction between natural compounds and human topoisomerase I S Castelli, A Coletta, I D’Annessa, P Fiorani, C Tesauro, A Desideri Biological Chemistry 393 (11), 1327-1340, 2012 | 57 | 2012 |
| Real-time label-free direct electronic monitoring of topoisomerase enzyme binding kinetics on graphene L Zuccaro, C Tesauro, T Kurkina, P Fiorani, HK Yu, BR Knudsen, K Kern, ... ACS nano 9 (11), 11166-11176, 2015 | 56 | 2015 |
| Synthesis and biological evaluation of indeno [1, 5] naphthyridines as topoisomerase I (TopI) inhibitors with antiproliferative activity C Alonso, M Fuertes, M González, G Rubiales, C Tesauro, BR Knudsen, ... European Journal of Medicinal Chemistry 115, 179-190, 2016 | 52 | 2016 |
| Erybraedin C, a natural compound from the plant Bituminaria bituminosa, inhibits both the cleavage and religation activities of human topoisomerase I C Tesauro, P Fiorani, I d'Annessa, G Chillemi, G Turchi, A Desideri Biochemical Journal 425 (3), 531-539, 2010 | 52 | 2010 |
| Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study C Tesauro, AK Simonsen, MB Andersen, KW Petersen, EL Kristoffersen, ... BMC cancer 19, 1-15, 2019 | 41 | 2019 |
| Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant P Fiorani, C Tesauro, G Mancini, G Chillemi, I D'A; nnessa, G Graziani, ... Nucleic acids research 37 (20), 6849-6858, 2009 | 35 | 2009 |
| Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico C Tesauro, B Morozzo della Rocca, A Ottaviani, A Coletta, L Zuccaro, ... Molecular cancer 12, 1-13, 2013 | 34 | 2013 |
| Conjugated eicosapentaenoic acid inhibits human topoisomerase IB with a mechanism different from camptothecin S Castelli, A Campagna, O Vassallo, C Tesauro, P Fiorani, P Tagliatesta, ... Archives of biochemistry and biophysics 486 (2), 103-110, 2009 | 34 | 2009 |
| Synthesis of novel hybrid quinolino [4, 3-b][1, 5] naphthyridines and quinolino [4, 3-b][1, 5] naphthyridin-6 (5H)-one derivatives and biological evaluation as topoisomerase I … E Martin-Encinas, A Selas, C Tesauro, G Rubiales, BR Knudsen, ... European Journal of Medicinal Chemistry 195, 112292, 2020 | 25 | 2020 |
| Decreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase I A Roy, C Tesauro, R Frøhlich, MS Hede, MJ Nielsen, E Kjeldsen, ... PloS one 9 (6), e99628, 2014 | 25 | 2014 |
| The human topoisomerase 1B Arg634Ala mutation results in camptothecin resistance and loss of inter-domain motion correlation I D'Annessa, C Tesauro, Z Wang, B Arnò, L Zuccaro, P Fiorani, A Desideri Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1834 (12), 2712-2721, 2013 | 17 | 2013 |
| Specific detection of topoisomerase I from the malaria causing P. falciparum parasite using isothermal rolling circle amplification C Tesauro, S Juul, B Arnò, CJF Nielsen, P Fiorani, RF Frøhlich, ... 2012 Annual International Conference of the IEEE Engineering in Medicine and …, 2012 | 16 | 2012 |
| Replacement of the human topoisomerase linker domain with the plasmodial counterpart renders the enzyme camptothecin resistant B Arnò, I D’Annessa, C Tesauro, L Zuccaro, A Ottaviani, B Knudsen, ... PLoS One 8 (7), e68404, 2013 | 15 | 2013 |
| Genetic and molecular characterization of the immortalized murine hepatic stellate cell line GRX SK Schröder, HM Schüler, KV Petersen, C Tesauro, BR Knudsen, ... Cells 11 (9), 1504, 2022 | 14 | 2022 |
| Advantages of an optical nanosensor system for the mechanistic analysis of a novel topoisomerase I targeting drug: a case study MB Andersen, C Tesauro, M Gonzalez, EL Kristoffersen, C Alonso, ... Nanoscale 9 (5), 1886-1895, 2017 | 14 | 2017 |
| Role of flexibility in protein-DNA-drug recognition: the case of Asp677Gly-Val703Ile topoisomerase mutant hypersensitive to camptothecin I D'Annessa, C Tesauro, P Fiorani, G Chillemi, S Castelli, O Vassallo, ... Journal of amino acids 2012, 2012 | 14 | 2012 |
| Mutation of Gly717Phe in human topoisomerase 1B has an effect on enzymatic function, reactivity to the camptothecin anticancer drug and on the linker domain orientation Z Wang, I D'Annessa, C Tesauro, S Croce, A Ottaviani, P Fiorani, ... Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1854 (8), 860-868, 2015 | 13 | 2015 |
| Different camptothecin sensitivities in subpopulations of colon cancer cells correlate with expression of different phospho-isoforms of topoisomerase i with different activities C Tesauro, JG Keller, I Gromova, P Gromov, R Frøhlich, JU Erlandsen, ... Cancers 12 (5), 1240, 2020 | 12 | 2020 |
Birgitta R. KnudsenAarhus UniversityVerified email at mb.au.dk
