| Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia T Palomero, ML Sulis, M Cortina, PJ Real, K Barnes, M Ciofani, ... Nature medicine 13 (10), 1203-1210, 2007 | 1004 | 2007 |
| Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model CW Kinkade, M Castillo-Martin, A Puzio-Kuter, J Yan, TH Foster, H Gao, ... The Journal of clinical investigation 118 (9), 3051-3064, 2008 | 493 | 2008 |
| γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia PJ Real, V Tosello, T Palomero, M Castillo, E Hernando, E De Stanchina, ... Nature medicine 15 (1), 50-58, 2009 | 470 | 2009 |
| Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch-and hedgehog-dependent tumor-initiating cells J Domingo-Domenech, SJ Vidal, V Rodriguez-Bravo, M Castillo-Martin, ... Cancer cell 22 (3), 373-388, 2012 | 421 | 2012 |
| A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia D Herranz, A Ambesi-Impiombato, T Palomero, SA Schnell, L Belver, ... Nature medicine 20 (10), 1130-1137, 2014 | 392 | 2014 |
| Inactivation of p53 and Pten promotes invasive bladder cancer AM Puzio-Kuter, M Castillo-Martin, CW Kinkade, X Wang, TH Shen, ... Genes & development 23 (6), 675-680, 2009 | 368 | 2009 |
| Molecular pathways of urothelial development and bladder tumorigenesis M Castillo-Martin, J Domingo-Domenech, O Karni-Schmidt, T Matos, ... Urologic oncology: seminars and original investigations 28 (4), 401-408, 2010 | 315 | 2010 |
| PHF6 mutations in T-cell acute lymphoblastic leukemia P Van Vlierberghe, T Palomero, H Khiabanian, J Van der Meulen, ... Nature genetics 42 (4), 338-342, 2010 | 314 | 2010 |
| Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy A Aytes, A Mitrofanova, C Lefebvre, MJ Alvarez, M Castillo-Martin, ... Cancer cell 25 (5), 638-651, 2014 | 290 | 2014 |
| Massive parallel sequencing uncovers actionable FGFR2–PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma D Sia, B Losic, A Moeini, L Cabellos, K Hao, K Revill, D Bonal, ... Nature communications 6 (1), 6087, 2015 | 282 | 2015 |
| Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia E Piovan, J Yu, V Tosello, D Herranz, A Ambesi-Impiombato, AC Da Silva, ... Cancer cell 24 (6), 766-776, 2013 | 257 | 2013 |
| An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer M Chen, J Zhang, K Sampieri, JG Clohessy, L Mendez, ... Nature genetics 50 (2), 206-218, 2018 | 236 | 2018 |
| A systems biology approach identifies FUT8 as a driver of melanoma metastasis P Agrawal, B Fontanals-Cirera, E Sokolova, S Jacob, CA Vaiana, ... Cancer cell 31 (6), 804-819. e7, 2017 | 231 | 2017 |
| EMT-and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer L Wang, A Saci, PM Szabo, SD Chasalow, M Castillo-Martin, ... Nature communications 9 (1), 3503, 2018 | 211 | 2018 |
| PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth S Kuchay, C Giorgi, D Simoneschi, J Pagan, S Missiroli, A Saraf, ... Nature 546 (7659), 554-558, 2017 | 196 | 2017 |
| Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia D Herranz, A Ambesi-Impiombato, J Sudderth, M Sánchez-Martín, ... Nature medicine 21 (10), 1182-1189, 2015 | 192 | 2015 |
| The metabolic co-regulator PGC1α suppresses prostate cancer metastasis V Torrano, L Valcarcel-Jimenez, AR Cortazar, X Liu, J Urosevic, ... Nature cell biology 18 (6), 645-656, 2016 | 191 | 2016 |
| Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression M Chen, CP Pratt, ME Zeeman, N Schultz, BS Taylor, A O'Neill, ... Cancer cell 20 (2), 173-186, 2011 | 171 | 2011 |
| The TLX1 oncogene drives aneuploidy in T cell transformation K De Keersmaecker, PJ Real, GD Gatta, T Palomero, ML Sulis, V Tosello, ... Nature medicine 16 (11), 1321-1327, 2010 | 162 | 2010 |
| Distinct expression profiles of p63 variants during urothelial development and bladder cancer progression O Karni-Schmidt, M Castillo-Martin, T HuaiShen, N Gladoun, ... The American journal of pathology 178 (3), 1350-1360, 2011 | 156 | 2011 |
