Brian Coombes
Brian Coombes
McMaster University, Department of Biochemistry and Biomedical Sciences
Verified email at - Homepage
Cited by
Cited by
A draft genome of Yersinia pestis from victims of the Black Death
KI Bos, VJ Schuenemann, GB Golding, HA Burbano, N Waglechner, ...
Nature 478 (7370), 506-510, 2011
Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance
AM King, SA Reid-Yu, W Wang, DT King, G De Pascale, NC Strynadka, ...
Nature 510 (7506), 503-506, 2014
Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy
L Ejim, MA Farha, SB Falconer, J Wildenhain, BK Coombes, M Tyers, ...
Nature Chemical Biology 7 (6), 348-350, 2011
Targeted enrichment of ancient pathogens yielding the pPCP1 plasmid of Yersinia pestis from victims of the Black Death
VJ Schuenemann, K Bos, S DeWitte, S Schmedes, J Jamieson, A Mittnik, ...
Proceedings of the National Academy of Sciences 108 (38), E746-E752, 2011
Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance
JM Stokes, CR MacNair, B Ilyas, S French, JP Côté, C Bouwman, ...
Nature microbiology 2 (5), 1-8, 2017
Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics
CR MacNair, JM Stokes, LA Carfrae, AA Fiebig-Comyn, BK Coombes, ...
Nature communications 9 (1), 458, 2018
Molecular analysis as an aid to assess the public health risk of non-O157 Shiga toxin-producing Escherichia coli strains
BK Coombes, ME Wickham, M Mascarenhas, S Gruenheid, BB Finlay, ...
Applied Environmental Microbiology 74 (7), 2153-2160, 2008
Expression and secretion of Salmonella pathogenicity island-2 virulence genes in response to acidification exhibit differential requirements of a functional type III secretion …
BK Coombes, NF Brown, Y Valdez, JH Brumell, BB Finlay
Journal of Biological Chemistry 279 (48), 49804-49815, 2004
Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling
EJ Culp, N Waglechner, W Wang, AA Fiebig-Comyn, YP Hsu, K Koteva, ...
Nature 578 (7796), 582-587, 2020
Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes
JHE Nash, A Villegas, AM Kropinski, R Aguilar-Valenzuela, P Konczy, ...
BMC Genomics 11 (1), 667, 2010
Analysis of the contribution of Salmonella pathogenicity islands 1 and 2 to enteric disease progression using a novel bovine ileal loop model and a murine model of infectious …
BK Coombes, BA Coburn, AA Potter, S Gomis, K Mirakhur, Y Li, BB Finlay
Infection and Immunity 73 (11), 7161-7169, 2005
Muramyl dipeptide-based postbiotics mitigate obesity-induced insulin resistance via IRF4
JF Cavallari, MD Fullerton, BM Duggan, KP Foley, E Denou, BK Smith, ...
Cell metabolism 25 (5), 1063-1074. e3, 2017
Persistent infection with Crohn’s disease-associated adherent-invasive Escherichia coli leads to chronic inflammation and intestinal fibrosis
CLN Small, SA Reid-Yu, JB McPhee, BK Coombes
Nature communications 4 (1), 1957, 2013
Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine
NF Brown, BA Vallance, BK Coombes, Y Valdez, BA Coburn, BB Finlay
PLoS Pathogens 1 (3), e32, 2005
Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis
MS Ladinsky, LP Araujo, X Zhang, J Veltri, M Galan-Diez, S Soualhi, ...
Science 363 (6431), eaat4042, 2019
FimH adhesin of type 1 fimbriae is a potent inducer of innate antimicrobial responses which requires TLR4 and type 1 interferon signalling
AA Ashkar, KL Mossman, BK Coombes, CL Gyles, R Mackenzie
PLoS Pathogens 4 (12), e1000233, 2008
Identification of MEK‐and phosphoinositide 3‐kinase‐dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cells
BK Coombes, JB Mahony
Cellular Microbiology 4 (7), 447-460, 2002
Chlamydia pneumoniae infection of human endothelial cells induces proliferation of smooth muscle cells via an endothelial cell-derived soluble factor (s)
BK Coombes, JB Mahony
Infection and Immunity 67 (6), 2909-2915, 1999
Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection
ME Wickham, C Lupp, M Mascarenhas, A Vázquez, BK Coombes, ...
The Journal of Infectious Diseases 194 (6), 819-827, 2006
Crossing the line: selection and evolution of virulence traits
NF Brown, ME Wickham, BK Coombes, BB Finlay
PLoS Pathogens 2 (5), e42, 2006
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