Francesco Sirci
Title
Cited by
Cited by
Year
Virtual Fragment Screening: Discovery of Histamine H3 Receptor Ligands Using Ligand-Based and Protein-Based Molecular Fingerprints
F Sirci, EP Istyastono, HF Vischer, AJ Kooistra, S Nijmeijer, M Kuijer, ...
Journal of chemical information and modeling 52 (12), 3308-3324, 2012
772012
Mantra 2.0: an online collaborative resource for drug mode of action and repurposing by network analysis
D Carrella, F Napolitano, R Rispoli, M Miglietta, A Carissimo, L Cutillo, ...
Bioinformatics 30 (12), 1787-1788, 2014
742014
Goblet cell hyperplasia requires high bicarbonate transport to support mucin release
G Gorrieri, P Scudieri, E Caci, M Schiavon, V Tomati, F Sirci, F Napolitano, ...
Scientific reports 6 (1), 1-15, 2016
612016
Drug-set enrichment analysis: a novel tool to investigate drug mode of action
F Napolitano, F Sirci, D Carrella, D di Bernardo
Bioinformatics 32 (2), 235-241, 2016
592016
Ligand-, structure-and pharmacophore-based molecular fingerprints: a case study on adenosine A 1, A 2A, A 2B, and A 3 receptor antagonists
F Sirci, L Goracci, D Rodríguez, J van Muijlwijk-Koezen, ...
Journal of computer-aided molecular design 26 (11), 1247-1266, 2012
552012
Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists
M Wijtmans, D Maussang, F Sirci, DJ Scholten, M Canals, A Mujić-Delić, ...
European journal of medicinal chemistry 51, 184-192, 2012
492012
Detailed analysis of biased histamine H4 receptor signalling by JNJ 7777120 analogues
S Nijmeijer, HF Vischer, F Sirci, S Schultes, H Engelhardt, C De Graaf, ...
British journal of pharmacology 170 (1), 78-88, 2013
452013
gene2drug: a computational tool for pathway-based rational drug repositioning
F Napolitano, D Carrella, B Mandriani, S Pisonero-Vaquero, F Sirci, ...
Bioinformatics 34 (9), 1498-1505, 2018
392018
Computational drugs repositioning identifies inhibitors of oncogenic PI3K/AKT/P70S6K-dependent pathways among FDA-approved compounds
D Carrella, I Manni, B Tumaini, R Dattilo, F Papaccio, M Mutarelli, F Sirci, ...
Oncotarget 7 (37), 58743, 2016
282016
Comparing structural and transcriptional drug networks reveals signatures of drug activity and toxicity in transcriptional responses
F Sirci, F Napolitano, S Pisonero-Vaquero, D Carrella, DL Medina, ...
NPJ systems biology and applications 3 (1), 1-12, 2017
192017
Evaluation of a systems biology approach to identify pharmacological correctors of the mutant CFTR chloride channel
E Pesce, G Gorrieri, F Sirci, F Napolitano, D Carrella, E Caci, V Tomati, ...
Journal of Cystic Fibrosis 15 (4), 425-435, 2016
142016
Absolute configuration and biological profile of two thiazinooxadiazol-3-ones with L-type calcium channel activity: a study of the structural effects
P Ioan, A Ciogli, F Sirci, R Budriesi, B Cosimelli, M Pierini, E Severi, ...
Organic & biomolecular chemistry 10 (45), 8994-9003, 2012
82012
Computational Drug Networks: a computational approach to elucidate drug mode of action and to facilitate drug repositioning for neurodegenerative diseases
F Sirci, F Napolitano, D di Bernardo
Drug Discovery Today: Disease Models 19, 11-17, 2016
52016
Pharmacoproteomics pinpoints HSP70 interaction for correction of the most frequent Wilson disease-causing mutant of ATP7B
M Concilli, R Petruzzelli, S Parisi, F Catalano, F Sirci, F Napolitano, ...
Proceedings of the National Academy of Sciences 117 (51), 32453-32463, 2020
22020
Optimizing virtual fragment screening for GPCRs: identification of novel ligands for the histamine H3 receptor using ligand-based and structure-based molecular fingerprints
F Sirci, EP Istyastono, HF Vischer, AJ Kooistra, S Nijmeijer, M Kuijer, ...
J Med Chem, 2012
22012
Integrated Structure-Transcription analysis of small molecules reveals widespread noise in drug-induced transcriptional responses and a transcriptional signature for drug …
F Sirci, F Napolitano, S Pisonero-Vaquero, D Carrella, DL Medina, ...
bioRxiv, 119990, 2017
2017
Fragment-based virtual screening: hunting for novel H 3 ligands via FLAP-GRID MIFs
F Sirci, EP Istyastono, HF Vischer, AJ Kooistra, S Nijmeijer, M Kuijer, ...
F1000Research 3, 2012
2012
Optimizing virtual fragment screening for GPCRs: Identification of novel ligands for the histamine H3 receptor using ligand-and structure-based molecular fingerprints
F Sirci, EP Istyastono, HF Vischer, S Nijmeijer, M Kuijer, AJ Kooistra, ...
Journal of Chemical Information and Modeling 52, 3308-3324, 2012
2012
The system can't perform the operation now. Try again later.
Articles 1–18