Chin-Yuan Chang
Chin-Yuan Chang
National Yang Ming Chiao Tung University
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Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function
JD Rudolf, CY Chang, M Ma, B Shen
Natural product reports 34 (9), 1141-1172, 2017
Crystal structure and inhibition studies of transglutaminase from Streptomyces mobaraense
MT Yang, CH Chang, JM Wang, TK Wu, YK Wang, CY Chang, THT Li
Journal of Biological Chemistry 286 (9), 7301-7307, 2011
Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne
X Yan, JJ Chen, A Adhikari, D Yang, I Crnovcic, N Wang, CY Chang, ...
Organic letters 19 (22), 6192-6195, 2017
Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms
CY Chang, SY Lyu, YC Liu, NS Hsu, CC Wu, CF Tang, KH Lin, JY Ho, ...
Angewandte Chemie 126 (7), 1974-1979, 2014
Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases
JD Rudolf, CY Chang
Natural product reports 37 (3), 425-463, 2020
Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase
JD Rudolf, LB Dong, H Cao, C Hatzos-Skintges, J Osipiuk, M Endres, ...
Journal of the American Chemical Society 138 (34), 10905-10915, 2016
Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase
XW Zou, YC Liu, NS Hsu, CJ Huang, SY Lyu, HC Chan, CY Chang, ...
Acta Crystallographica Section D: Biological Crystallography 70 (6), 1549-1560, 2014
Comparative studies of the biosynthetic gene clusters for anthraquinone-fused enediynes shedding light into the tailoring steps of tiancimycin biosynthesis
X Yan, JJ Chen, A Adhikari, CN Teijaro, H Ge, I Crnovcic, CY Chang, ...
Organic letters 20 (18), 5918-5921, 2018
Genome mining and biosynthesis of kitacinnamycins as a STING activator
J Shi, CL Liu, B Zhang, WJ Guo, J Zhu, CY Chang, EJ Zhao, RH Jiao, ...
Chemical science 10 (18), 4839-4846, 2019
Multiple Complexes of Long Aliphatic N-Acyltransferases Lead to Synthesis of 2,6-Diacylated/2-Acyl-Substituted Glycopeptide Antibiotics, Effectively Killing …
SY Lyu, YC Liu, CY Chang, CJ Huang, YH Chiu, CM Huang, NS Hsu, ...
Journal of the American Chemical Society 136 (31), 10989-10995, 2014
Biochemical and structural characterization of TtnD, a prenylated FMN-dependent decarboxylase from the tautomycetin biosynthetic pathway
T Annaval, L Han, JD Rudolf, G Xie, D Yang, CY Chang, M Ma, I Crnovcic, ...
ACS Chemical Biology 13 (9), 2728-2738, 2018
Insights into the binding specificity and catalytic mechanism of N-acetylhexosamine 1-phosphate kinases through multiple reaction complexes
KC Wang, SY Lyu, YC Liu, CY Chang, CJ Wu, TL Li
Acta Crystallographica Section D: Biological Crystallography 70 (5), 1401-1410, 2014
Resistance to enediyne antitumor antibiotics by sequestration
CY Chang, X Yan, I Crnovcic, T Annaval, C Chang, B Nocek, JD Rudolf, ...
Cell chemical biology 25 (9), 1075-1085. e4, 2018
Crystal structures of SgcE6 and SgcC, the two-component monooxygenase that catalyzes hydroxylation of a carrier protein-tethered substrate during the biosynthesis of the …
CY Chang, JR Lohman, H Cao, K Tan, JD Rudolf, M Ma, W Xu, ...
Biochemistry 55 (36), 5142-5154, 2016
Crystal structure and mutational analysis of aminoacylhistidine dipeptidase from Vibrio alginolyticus reveal a new architecture of M20 metallopeptidases
CY Chang, YC Hsieh, TY Wang, YC Chen, YK Wang, TW Chiang, ...
Journal of Biological Chemistry 285 (50), 39500-39510, 2010
Expression and characterization of the biofilm‐related and carnosine‐hydrolyzing aminoacylhistidine dipeptidase from Vibrio alginolyticus
TY Wang, YC Chen, LW Kao, CY Chang, YK Wang, YH Liu, JM Feng, ...
The FEBS Journal 275 (20), 5007-5020, 2008
Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme
N Wang, JD Rudolf, LB Dong, J Osipiuk, C Hatzos-Skintges, M Endres, ...
Nature chemical biology 14 (7), 730-737, 2018
Structural insights into the free-standing condensation enzyme SgcC5 catalyzing ester-bond formation in the biosynthesis of the enediyne antitumor antibiotic C-1027
CY Chang, JR Lohman, T Huang, K Michalska, L Bigelow, JD Rudolf, ...
Biochemistry 57 (23), 3278-3288, 2018
Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892
JD Rudolf, L Bigelow, C Chang, ME Cuff, JR Lohman, CY Chang, M Ma, ...
Biochemistry 54 (45), 6842-6851, 2015
Discovery of alternative producers of the enediyne antitumor antibiotic C-1027 with high titers
X Yan, Hindra, H Ge, D Yang, T Huang, I Crnovcic, CY Chang, SM Fang, ...
Journal of natural products 81 (3), 594-599, 2018
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