| Properties and applications of starch-converting enzymes of the α-amylase family MJEC Van Der Maarel, B Van der Veen, JCM Uitdehaag, H Leemhuis, ... Journal of biotechnology 94 (2), 137-155, 2002 | 1915 | 2002 |
| X-ray structures along the reaction pathway of cyclodextrin glycosyltransferase elucidate catalysis in the α-amylase family J Uitdehaag, R Mosi, KH Kalk, BA van der Veen, L Dijkhuizen, SG Withers, ... nature structural biology 6 (5), 432-436, 1999 | 525 | 1999 |
| Engineering of cyclodextrin glycosyltransferase reaction and product specificity BA van der Veen, JCM Uitdehaag, BW Dijkstra, L Dijkhuizen Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular …, 2000 | 266 | 2000 |
| The three transglycosylation reactions catalyzed by cyclodextrin glycosyltransferase from Bacillus circulans (strain 251) proceed via different kinetic mechanisms BA van der Veen, GJWM van Alebeek, JCM Uitdehaag, BW Dijkstra, ... European Journal of Biochemistry 267 (3), 658-665, 2000 | 212 | 2000 |
| Crystal structure of the CUB1‐EGF‐CUB2 region of mannose‐binding protein associated serine protease‐2 H Feinberg, JCM Uitdehaag, JM Davies, R Wallis, K Drickamer, WI Weis The EMBO journal, 2003 | 159 | 2003 |
| The cyclization mechanism of cyclodextrin glycosyltransferase (CGTase) as revealed by a γ-cyclodextrin-CGTase complex at 1.8-Å resolution JCM Uitdehaag, KH Kalk, BA van der Veen, L Dijkhuizen, BW Dijkstra Journal of Biological Chemistry 274 (49), 34868-34876, 1999 | 157 | 1999 |
| Engineering of cyclodextrin product specificity and pH optima of the thermostable cyclodextrin glycosyltransferase from Thermoanaerobacterium thermosulfurigenes EM1 RD Wind, JCM Uitdehaag, RM Buitelaar, BW Dijkstra, L Dijkhuizen Journal of Biological Chemistry 273 (10), 5771-5779, 1998 | 148 | 1998 |
| Localization of the serine protease-binding sites in the collagen-like domain of mannose-binding protein: indirect effects of naturally occurring mutations on protease binding … R Wallis, JM Shaw, J Uitdehaag, CB Chen, D Torgersen, K Drickamer Journal of Biological Chemistry 279 (14), 14065-14073, 2004 | 132 | 2004 |
| Localization of the serine protease-binding sites in the collagen-like domain of mannose-binding protein: indirect effects of naturally occurring mutations on protease binding … R Wallis, JM Shaw, J Uitdehaag, CB Chen, D Torgersen, K Drickamer Journal of Biological Chemistry 279 (14), 14065-14073, 2004 | 132 | 2004 |
| A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets JCM Uitdehaag, F Verkaar, H Alwan, J de Man, RC Buijsman, ... British journal of pharmacology 166 (3), 858-876, 2012 | 131 | 2012 |
| Hydrophobic amino acid residues in the acceptor binding site are main determinants for reaction mechanism and specificity of cyclodextrin-glycosyltransferase BA van der Veen, H Leemhuis, S Kralj, JCM Uitdehaag, BW Dijkstra, ... Journal of Biological Chemistry 276 (48), 44557-44562, 2001 | 130 | 2001 |
| Rational design of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 to increase α-cyclodextrin production BA van der Veen, JCM Uitdehaag, D Penninga, GJWM van Alebeek, ... Journal of Molecular Biology 296 (4), 1027-1038, 2000 | 116 | 2000 |
| Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model ARR Maia, J de Man, U Boon, A Janssen, JY Song, M Omerzu, ... Annals of Oncology 26 (10), 2180-2192, 2015 | 113 | 2015 |
| Comparison of the cancer gene targeting and biochemical selectivities of all targeted kinase inhibitors approved for clinical use JCM Uitdehaag, JADM de Roos, AM van Doornmalen, MBW Prinsen, ... PloS one 9 (3), e92146, 2014 | 111 | 2014 |
| Structures of maltohexaose and maltoheptaose bound at the donor sites of cyclodextrin glycosyltransferase give insight into the mechanisms of transglycosylation activity and … JCM Uitdehaag, GJWM van Alebeek, BA van der Veen, L Dijkhuizen, ... Biochemistry 39 (26), 7772-7780, 2000 | 106 | 2000 |
| Trapping and characterization of the reaction intermediate in cyclodextrin glycosyltransferase by use of activated substrates and a mutant enzyme R Mosi, S He, J Uitdehaag, BW Dijkstra, SG Withers Biochemistry 36 (32), 9927-9934, 1997 | 95 | 1997 |
| MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia K Canté-Barrett, JAP Spijkers-Hagelstein, J Buijs-Gladdines, ... Leukemia 30 (9), 1832-1843, 2016 | 89 | 2016 |
| Catalytic mechanism and product specificity of cyclodextrin glycosyltransferase, a prototypical transglycosylase from the α-amylase family JCM Uitdehaag, BA van der Veen, L Dijkhuizen, BW Dijkstra Enzyme and Microbial Technology 30 (3), 295-304, 2002 | 86 | 2002 |
| The role of arginine 47 in the cyclization and coupling reactions of cyclodextrin glycosyltransferase from Bacillus circulans strain 251: Implications for product … BA van der Veen, JCM Uitdehaag, BW Dijkstra, L Dijkhuizen European journal of biochemistry 267 (12), 3432-3441, 2000 | 84 | 2000 |
| Reassessment of acarbose as a transition state analogue inhibitor of cyclodextrin glycosyltransferase R Mosi, H Sham, JCM Uitdehaag, R Ruiterkamp, BW Dijkstra, SG Withers Biochemistry 37 (49), 17192-17198, 1998 | 84 | 1998 |
Hans LeemhuisPrincipal scientistVerified email at avebe.com
