| Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail approach HO Tawfik, A Petreni, CT Supuran, MH El-Hamamsy European Journal of Medicinal Chemistry 232 (15), 1-20, 2022 | 32 | 2022 |
| Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors HO Tawfik, TF El-Moselhy, NA Sharafeldin, MH El-Hamamsy Bioorganic & Medicinal Chemistry 27 (23), 1-16, 2019 | 22 | 2019 |
| Ligand-based design on the dog-bone-shaped BIBR1532 pharmacophoric features and synthesis of novel analogues as promising telomerase inhibitors with in vitro and in vivo … AA Al-Karmalawy, MS Nafie, MA Shaldam, AA Elmaaty, SA Antar, ... Journal of Medicinal Chemistry 66 (1), 777-792, 2022 | 21 | 2022 |
| The plausible mechanisms of tramadol for treatment of COVID-19 NE El-Ashmawy, AHA Lashin, KM Okasha, AMA Kamer, TM Mostafa, ... Medical Hypotheses 146, 110468, 2021 | 21 | 2021 |
| Novel 3-(6-methylpyridin-2-yl) coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity HO Tawfik, MA Shaldam, A Nocentini, R Salem, H Almahli, ... Journal of enzyme inhibition and medicinal chemistry 37 (1), 1043-1052, 2022 | 15 | 2022 |
| Design, synthesis, and molecular docking study of new monastrol analogues as kinesin spindle protein inhibitors MH El‐Hamamsy, NA Sharafeldin, TF El‐Moselhy, HO Tawfik Archiv der Pharmazie 353 (8), 1-18, 2020 | 15 | 2020 |
| Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors MA Shaldam, H Almahli, A Angeli, RM Badi, EF Khaleel, ... Journal of Enzyme Inhibition and Medicinal Chemistry 38 (1), 2203389, 2023 | 13 | 2023 |
| Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics … F Farouk, AA Elmaaty, A Elkamhawy, HO Tawfik, R Alnajjar, ... Journal of Enzyme Inhibition and Medicinal Chemistry 38 (1), 2171029, 2023 | 13 | 2023 |
| Terminators or guardians? design, synthesis, and cytotoxicity profiling of chalcone-sulfonamide hybrids SM Aboukhatwa, PA Sidhom, A Angeli, CT Supuran, HO Tawfik ACS omega 8 (8), 7666-7683, 2023 | 13 | 2023 |
| Dependence on linkers’ flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents HO Tawfik, A Belal, MAS Abourehab, A Angeli, A Bonardi, CT Supuran, ... Journal of Enzyme Inhibition and Medicinal Chemistry 37 (1), 2765-2785, 2022 | 12 | 2022 |
| New Genetic Bomb Trigger: Design, Synthesis, Molecular Dynamics Simulation, and Biological Evaluation of Novel BIBR1532-Related Analogs Targeting Telomerase against Non-Small … HO Tawfik, AA El-Hamaky, EA El-Bastawissy, KA Shcherbakov, ... Pharmaceuticals 15 (4), 481, 2022 | 12 | 2022 |
| Novel 4-(2-arylidenehydrazineyl) thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico insights HA Elsebaie, EA El-Bastawissy, KM Elberembally, EF Khaleel, RM Badi, ... Bioorganic Chemistry 140, 106799, 2023 | 10 | 2023 |
| Nicotinonitrile-derived apoptotic inducers: Design, synthesis, X-ray crystal structure and Pim kinase inhibition SM Aboukhatwa, AO Ibrahim, H Aoyama, AS Al-Behery, MA Shaldam, ... Bioorganic Chemistry 129, 106126, 2022 | 10 | 2022 |
| Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and … AA Al-Karmalawy, M Rashed, M Sharaky, HS Abulkhair, MM Hammouda, ... European Journal of Medicinal Chemistry 259, 115661, 2023 | 9 | 2023 |
| Synthesis, crystallographic, DNA binding, and molecular docking/dynamic studies of a privileged chalcone-sulfonamide hybrid scaffold as a promising anticancer agent M Shaldam, H Tawfik, H Elmansi, F Belal, K Yamaguchi, M Sugiura, ... Journal of Biomolecular Structure and Dynamics 41 (18), 8876-8890, 2023 | 7 | 2023 |
| Evaluating the ability of some natural phenolic acids to target the main protease and AAK1 in SARS COV-2 HI Ghamry, A Belal, MK El-Ashrey, HO Tawfik, RI Alsantali, AJ Obaidullah, ... Scientific Reports 13 (1), 7357, 2023 | 6 | 2023 |
| Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, in vitro assays, and … MH Saad, TF El-Moselhy, N S, El-Din, ABM Mehany, A Belal, ... Journal of Enzyme Inhibition and Medicinal Chemistry 37 (1), 2489-2511, 2022 | 6 | 2022 |
| LC-MS/MS metabolomics profiling of Glechoma hederacea L. methanolic extract; in vitro antimicrobial and in vivo with in silico wound healing studies on Staphylococcus aureus … M El-Aasr, T Nohara, T Ikeda, SE Abu-Risha, E Elekhnawy, HO Tawfik, ... Natural Product Research 37 (10), 1730-1734, 2023 | 5 | 2023 |
| Toxoplasmocidal and Cytotoxic Activities Guided Isolation and Characterization of an Undescribed Bioflavonoid-di-C-glucoside from Cycas rumphii Miq. Cultivated … HM El-Seadawy, KA Abo El-Seoud, M El-Aasr, HO Tawfik, AE Ragab Plants 11 (21), 2867, 2022 | 5 | 2022 |
| 2, 4-Diaryl-pyrimido [1, 2-a] benzimidazole derivatives as novel anticancer agents endowed with potent anti-leukemia activity: Synthesis, biological evaluation and kinase profiling MA Shaldam, D Hendrychová, R El-Haggar, V Vojáčková, TA Majrashi, ... European Journal of Medicinal Chemistry 258, 115610, 2023 | 4 | 2023 |
Moataz Ahmed ShaldamAssistant Professor of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh UniversityVerified email at pharm.kfs.edu.eg
