Pawel Muranski
Pawel Muranski
Columbia University Medical Center
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Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
L Gattinoni, XS Zhong, DC Palmer, Y Ji, CS Hinrichs, Z Yu, C Wrzesinski, ...
Nature medicine 15 (7), 808-813, 2009
Tumor-specific Th17-polarized cells eradicate large established melanoma
P Muranski, A Boni, PA Antony, L Cassard, KR Irvine, A Kaiser, ...
Blood, The Journal of the American Society of Hematology 112 (2), 362-373, 2008
Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts
SA Quezada, TR Simpson, KS Peggs, T Merghoub, J Vider, X Fan, ...
Journal of Experimental Medicine 207 (3), 637-650, 2010
T helper 17 cells promote cytotoxic T cell activation in tumor immunity
N Martin-Orozco, P Muranski, Y Chung, XO Yang, T Yamazaki, S Lu, ...
Immunity 31 (5), 787-798, 2009
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
M Sukumar, J Liu, Y Ji, M Subramanian, JG Crompton, Z Yu, ...
The Journal of clinical investigation 123 (10), 4479-4488, 2013
Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling
CM Paulos, C Wrzesinski, A Kaiser, CS Hinrichs, M Chieppa, L Cassard, ...
The Journal of clinical investigation 117 (8), 2197-2204, 2007
Naive tumor-specific CD4+ T cells differentiated in vivo eradicate established melanoma
Y Xie, A Akpinarli, C Maris, EL Hipkiss, M Lane, EKM Kwon, P Muranski, ...
Journal of Experimental Medicine 207 (3), 651-667, 2010
Th17 cells are long lived and retain a stem cell-like molecular signature
P Muranski, ZA Borman, SP Kerkar, CA Klebanoff, Y Ji, L Sanchez-Perez, ...
Immunity 35 (6), 972-985, 2011
Essentials of Th17 cell commitment and plasticity
P Muranski, NP Restifo
Blood, The Journal of the American Society of Hematology 121 (13), 2402-2414, 2013
Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity
CS Hinrichs, ZA Borman, L Cassard, L Gattinoni, R Spolski, Z Yu, ...
Proceedings of the National Academy of Sciences 106 (41), 17469-17474, 2009
BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis
R Roychoudhuri, K Hirahara, K Mousavi, D Clever, CA Klebanoff, ...
Nature 498 (7455), 506-510, 2013
Increased intensity lymphodepletion and adoptive immunotherapy—how far can we go?
P Muranski, A Boni, C Wrzesinski, DE Citrin, SA Rosenberg, R Childs, ...
Nature clinical practice Oncology 3 (12), 668-681, 2006
IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors
SP Kerkar, RS Goldszmid, P Muranski, D Chinnasamy, Z Yu, RN Reger, ...
The Journal of clinical investigation 121 (12), 4746-4757, 2011
Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy
CS Hinrichs, ZA Borman, L Gattinoni, Z Yu, WR Burns, J Huang, ...
Blood, The Journal of the American Society of Hematology 117 (3), 808-814, 2011
Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics
JG Crompton, M Sukumar, R Roychoudhuri, D Clever, A Gros, RL Eil, ...
Cancer research 75 (2), 296-305, 2015
Mitochondrial membrane potential identifies cells with enhanced stemness for cellular therapy
M Sukumar, J Liu, GU Mehta, SJ Patel, R Roychoudhuri, JG Crompton, ...
Cell metabolism 23 (1), 63-76, 2016
Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells
C Wrzesinski, CM Paulos, A Kaiser, P Muranski, DC Palmer, L Gattinoni, ...
Journal of immunotherapy 33 (1), 1-7, 2010
Determinants of Successful CD8+ T-Cell Adoptive Immunotherapy for Large Established Tumors in Mice
CA Klebanoff, L Gattinoni, DC Palmer, P Muranski, Y Ji, CS Hinrichs, ...
Clinical Cancer Research 17 (16), 5343-5352, 2011
Pembrolizumab treatment for progressive multifocal leukoencephalopathy
I Cortese, P Muranski, Y Enose-Akahata, SK Ha, B Smith, MC Monaco, ...
New England Journal of Medicine 380 (17), 1597-1605, 2019
Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts
SP Kerkar, P Muranski, A Kaiser, A Boni, L Sanchez-Perez, Z Yu, ...
Cancer research 70 (17), 6725-6734, 2010
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