|5-Aminosalyclic Acid (5-ASA): A Unique Anti-Inflammatory Salicylate|
HHM Abdu-Allah, ANA El-Shorbagi, SG Abdel-Moty, EA Raafat, ...
Medicinal chemistry-OMICS International 6 (5), 306-315, 2016
|Design, synthesis, and structure− affinity relationships of novel series of sialosides as CD22-specific inhibitors|
HHM Abdu-Allah, T Tamanaka, J Yu, L Zhuoyuan, M Sadagopan, ...
Journal of medicinal chemistry 51 (21), 6665-6681, 2008
|Synthesis, biological evaluation and docking study of 1,3,4-thiadiazole-thiazolidinone hybrids as anti-inflammatory agents with dual inhibition of COX-2 and 15-LOX|
Y Omar, H Abdu-Allah, S Abdel-Moty
Bioorganic Chemistry, 2018
|CD22-antagonists with nanomolar potency: the synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold|
HHM Abdu-Allah, K Watanabe, GC Completo, M Sadagopan, ...
Bioorganic & medicinal chemistry 19 (6), 1966-1971, 2011
|Design and synthesis of novel 2, 3-dihydropyrazino [1, 2-a] indole-1, 4-dione derivatives as antiproliferative EGFR and BRAFV600E dual inhibitors|
LH Al-Wahaibi, AM Gouda, OF Abou-Ghadir, OIA Salem, AT Ali, ...
Bioorganic Chemistry 104, 104260, 2020
|Click chemistry synthesis, biological evaluation and docking study of some novel 2’-hydroxychalcone-triazole hybrids as potent anti-inflammatory agents|
AN Boshra, HHM Abdu-Allah, AF Mohammed, AM Hayallah
Bioorganic Chemistry, 2019
|Inhibition of SHP2 by new compounds induces differential effects on RAS/RAF/ERK and PI3K/AKT pathways in different cancer cell types|
CG Vazhappilly, E Saleh, W Ramadan, V Menon, AM Al-Azawi, H Tarazi, ...
Investigational New Drugs 37, 252–261, 2019
|Synthesis and anti-inflammatory testing of some new compounds incorporating 5-aminosalicylic acid (5-ASA) as potential prodrugs|
AAM Abdel-Alim, ANA El-Shorbagi, SG Abdel-Moty, HHM Abdel-Allah
Archives of pharmacal research 28 (6), 637-647, 2005
|Further insight into the dual COX-2 and 15-LOX anti-inflammatory activity of 1,3,4-thiadiazole-thiazolidinone hybrids: The contribution of the substituents at 5th positions is …|
HHMAA Yasser M. Omar, Samia G. Abdel-Moty
Bioorganic Chemistry, 2020
|CD22-Binding synthetic sialosides regulate B lymphocyte proliferation through CD22 ligand-dependent and independent pathways, and enhance antibody production in mice|
N Matsubara, A Imamura, T Yonemizu, C Akatsu, H Yang, A Ueki, ...
Frontiers in immunology 9, 820, 2018
|Proximity labeling of cis-ligands of CD22/Siglec-2 reveals stepwise α2,6 sialic acid-dependent and -independent interactions|
AA Deh Sheikh, C Akatsua, A Imamura, Abdu-Allah, H H. M., ...
Biochemical and Biophysical Research Communications 495 (1), 854-859, 2018
|Design and synthesis of novel 5-aminosalicylate (5-ASA)–4-thiazolinone hybrid derivatives with promising antiproliferative activity|
HHM Abdu-Allah, SG Abdel-Moty, R El-Awady, ANA El-Shorbagi
Bioorganic & Medicinal Chemistry Letters 26 (7), 1647-1650, 2016
|Potent small molecule mouse CD22-inhibitors: Exploring the interaction of the residue at C-2 of sialic acid scaffold|
HHM Abdu-Allah, K Watanabe, K Hayashizaki, C Takaku, T Tamanaka, ...
Bioorganic & medicinal chemistry letters 19 (19), 5573-5575, 2009
|Synthesis of some benzimidazole derivatives endowed with 1,2,3-triazole as potential inhibitors of hepatitis C virus|
BGM Youssif, YAM Mohamed, MTA Salim, F Inagaki, C Mukai, ...
Acta Pharmaceutica, 2016
|Novel N-substituted 5–aminosalicylamides as dual inhibitors of cyclooxygenase and 5-lipoxygenase enzymes: Synthesis, biological evaluation and docking study|
MKS El-Nagar, HHM Abdu-Allah, OIA Salem, AHN Kafafy, HSM Farghaly
Bioorganic Chemistry, 2018
|Synthesis of trigonelline and nicotinamide linked prodrugs of 5-aminosalicylic acid (5-ASA) with analgesic and anti-inflammatory effects|
HHM Abdu-Allah, SG Abdel-Moty, AA El-Shorbagi, AM Abdel-Alim
Bulletin of Pharmaceutical Sciences. Assiut 28 (2), 237-253, 2005
|Synthesis and anti-mycobacterial activity of 4-(4-phenyl-1H-1,2,3-triazol-1- yl)salicylhydrazones: revitalizing an old drug|
HHM Abdu-Allah, BGM Youssif, MH Abdelrahman, MK Abdel-Hamid, ...
Archives of Pharmacal Research 40 (2), 168-179., 2017
|Synthesis of biotinylated sialoside to probe CD22–ligand interactions|
HHM Abdu-Allah, K Watanabe, K Hayashizaki, Y Iwayama, H Takematsu, ...
Tetrahedron Letters 50 (31), 4488-4491, 2009
|Bis-(5-substituted-2-thiono-1,3,5-thiadiazinan-3-yl) butane as a scaffold of anti-proliferative activity, blended by a multicomponent process|
HO Abdel-Nasser El-Shorbagi, Mohamed El-Naggar, Hamadeh Tarazi, Sachin ...
Medicinal Chemistry Research, 1-8, 2018
|Induction of DNA damage, apoptosis and cell cycle perturbation mediate cytotoxic activity of new 5-aminosalicylate–4-thiazolinone hybrid derivatives|
WS Ramadan, EM Saleh, V Menon, CG Vazhappilly, HHM abdu-Allah, ...
Biomedicine & Pharmacotherapy 131, 110571, 2020