| C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector OO Abudayyeh, JS Gootenberg, S Konermann, J Joung, IM Slaymaker, ... Science 353 (6299), aaf5573, 2016 | 2264 | 2016 |
| Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature PG Arnison, MJ Bibb, G Bierbaum, AA Bowers, TS Bugni, G Bulaj, ... Natural product reports 30 (1), 108-160, 2013 | 2118 | 2013 |
| Discovery and functional characterization of diverse class 2 CRISPR-Cas systems S Shmakov, OO Abudayyeh, KS Makarova, YI Wolf, JS Gootenberg, ... Molecular cell 60 (3), 385-397, 2015 | 1421 | 2015 |
| Diversity and evolution of class 2 CRISPR–Cas systems S Shmakov, A Smargon, D Scott, D Cox, N Pyzocha, W Yan, ... Nature reviews microbiology 15 (3), 169-182, 2017 | 1112 | 2017 |
| Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 Ĺ resolution G Zhang, EA Campbell, L Minakhin, C Richter, K Severinov, SA Darst Cell 98 (6), 811-824, 1999 | 1068 | 1999 |
| Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence E Semenova, MM Jore, KA Datsenko, A Semenova, ER Westra, B Wanner, ... Proceedings of the National Academy of Sciences 108 (25), 10098-10103, 2011 | 1049 | 2011 |
| A third recognition element in bacterial promoters: DNA binding by the α subunit of RNA polymerase W Ross, KK Gosink, J Salomon, K Igarashi, C Zou, A Ishihama, ... Science 262 (5138), 1407-1413, 1993 | 1015 | 1993 |
| Multiplex gene editing by CRISPR–Cpf1 using a single crRNA array B Zetsche, M Heidenreich, P Mohanraju, I Fedorova, J Kneppers, ... Nature biotechnology 35 (1), 31-34, 2017 | 963 | 2017 |
| CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3 ER Westra, PBG van Erp, T Künne, SP Wong, RHJ Staals, CLC Seegers, ... Molecular cell 46 (5), 595-605, 2012 | 748 | 2012 |
| Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system KA Datsenko, K Pougach, A Tikhonov, BL Wanner, K Severinov, ... Nature communications 3 (1), 945, 2012 | 705 | 2012 |
| New developments in RiPP discovery, enzymology and engineering M Montalbán-López, TA Scott, S Ramesh, IR Rahman, AJ Van Heel, ... Natural product reports 38 (1), 130-239, 2021 | 552 | 2021 |
| Escherichia coli CspA-family RNA chaperones are transcription antiterminators W Bae, B Xia, M Inouye, K Severinov Proceedings of the National Academy of Sciences 97 (14), 7784-7789, 2000 | 491 | 2000 |
| Transcription, processing and function of CRISPR cassettes in Escherichia coli K Pougach, E Semenova, E Bogdanova, KA Datsenko, M Djordjevic, ... Molecular microbiology 77 (6), 1367-1379, 2010 | 330 | 2010 |
| Bacterial RNA polymerase subunit ω and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly L Minakhin, S Bhagat, A Brunning, EA Campbell, SA Darst, RH Ebright, ... Proceedings of the National Academy of Sciences 98 (3), 892-897, 2001 | 328 | 2001 |
| Expressed protein ligation, a novel method for studying protein-protein interactions in transcription K Severinov, TW Muir Journal of Biological Chemistry 273 (26), 16205-16209, 1998 | 304 | 1998 |
| Type IE CRISPR-cas systems discriminate target from non-target DNA through base pairing-independent PAM recognition ER Westra, E Semenova, KA Datsenko, RN Jackson, B Wiedenheft, ... PLoS genetics 9 (9), e1003742, 2013 | 281 | 2013 |
| Genome-Wide Identification of Regulatory RNAs in the Human Pathogen Clostridium difficile OA Soutourina, M Monot, P Boudry, L Saujet, C Pichon, O Sismeiro, ... PLoS genetics 9 (5), e1003493, 2013 | 278 | 2013 |
| Structure of microcin J25, a peptide inhibitor of bacterial RNA polymerase, is a lassoed tail KA Wilson, M Kalkum, J Ottesen, J Yuzenkova, BT Chait, R Landick, ... Journal of the American Chemical Society 125 (41), 12475-12483, 2003 | 276 | 2003 |
| Rifampicin region revisited. New rifampicin-resistant and streptolydigin-resistant mutants in the beta subunit of Escherichia coli RNA polymerase K Severinov, M Soushko, A Goldfarb, V Nikiforov Journal of Biological Chemistry 268 (20), 14820-14825, 1993 | 250 | 1993 |
| Regulation of elongation factor‐2 by multisite phosphorylation NT REDPATH, NT PRICE, KV SEVERINOV, CG PROUD European journal of biochemistry 213 (2), 689-699, 1993 | 228 | 1993 |
