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Christian M Stegmann
Christian M Stegmann
Absci
Verified email at absci.com
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Cited by
Year
Transcriptional and cellular diversity of the human heart
NR Tucker, M Chaffin, SJ Fleming, AW Hall, VA Parsons, K Bedi, ...
Circulation 2020 (142), 466–482, 2020
3482020
Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction
RC Hillig, B Sautier, J Schroeder, D Moosmayer, A Hilpmann, ...
Proceedings of the National Academy of Sciences 116 (7), 2551-2560, 2019
3142019
Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy
M Chaffin, I Papangeli, B Simonson, AD Akkad, MC Hill, A Arduini, ...
Nature 608 (7921), 174-180, 2022
1262022
Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons
JC Burnett, G Ruthel, CM Stegmann, RG Panchal, TL Nguyen, ...
Journal of biological chemistry 282 (7), 5004-5014, 2007
1192007
Deep learning enables genetic analysis of the human thoracic aorta
JP Pirruccello, MD Chaffin, EL Chou, SJ Fleming, H Lin, M Nekoui, ...
Nature genetics 54 (1), 40-51, 2022
1112022
Myocyte Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2 mediated myocarditis
NR Tucker, M Chaffin, KC Bedi, I Papangeli, AD Akkad, A Arduini, S Hayat, ...
Circulation 2020 (142), 708–710, 2020
1072020
Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis
P Burkhardt, CM Stegmann, B Cooper, TH Kloepper, C Imig, ...
Proceedings of the National Academy of Sciences 108 (37), 15264-15269, 2011
882011
Conformational adaption may explain the slow dissociation kinetics of roniciclib (BAY 1000394), a type I CDK inhibitor with kinetic selectivity for CDK2 and CDK9
P Ayaz, D Andres, DA Kwiatkowski, CC Kolbe, P Lienau, G Siemeister, ...
ACS chemical biology 11 (6), 1710-1719, 2016
702016
Structural and biochemical studies of botulinum neurotoxin serotype C1 light chain protease: implications for dual substrate specificity
R Jin, S Sikorra, CM Stegmann, A Pich, T Binz, AT Brunger
Biochemistry 46 (37), 10685-10693, 2007
562007
Discovery of a potent class I protein arginine methyltransferase fragment inhibitor
R Ferreira de Freitas, MS Eram, MM Szewczyk, H Steuber, D Smil, H Wu, ...
Journal of medicinal chemistry 59 (3), 1176-1183, 2016
392016
The thermodynamic influence of trapped water molecules on a protein–ligand interaction
CM Stegmann, D Seeliger, GM Sheldrick, BL de Groot, MC Wahl
Angewandte Chemie International Edition 48 (28), 5207-5210, 2009
382009
The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein
CM Stegmann, R Lührmann, MC Wahl
PloS one 5 (4), e10013, 2010
272010
An autoinhibited state in the structure of Thermotoga maritima NusG
J Drögemüller, CM Stegmann, A Mandal, T Steiner, BM Burmann, ...
Structure 21 (3), 365-375, 2013
202013
Substituted benzylpyrazoles
M Hitchcock, A Mengel, A Richter, H Briem, K Eis, V Pütter, G Siemeister, ...
US Patent 9,643,953, 2017
172017
MACA: marker-based automatic cell-type annotation for single-cell expression data
Y Xu, SJ Baumgart, CM Stegmann, S Hayat
Bioinformatics 38 (6), 1756-1760, 2022
132022
Human Cell Atlas Lung Biological Network
NR Tucker, M Chaffin, KC Bedi Jr, I Papangeli, AD Akkad, A Arduini, ...
Human Cell Atlas Lung Biological Network Consortium Members. Myocyte …, 2020
132020
Substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said new substituted indazoles, and use of said new substituted indazoles to …
U Bothe, H Siebeneicher, N Schmidt, R Nubbemeyer, U Bömer, J Günther, ...
US Patent 10,308,634, 2019
132019
Functional and structural characterization of Bub3· BubR1 interactions required for spindle assembly checkpoint signaling in human cells
F Prinz, V Puetter, SJ Holton, D Andres, CM Stegmann, D Kwiatkowski, ...
Journal Of Biological Chemistry 291 (21), 11252-11267, 2016
112016
Binding kinetics in drug discovery-A current perspective
V Georgi, D Andres, AE Fernandez-Montalvan, CM Stegmann, A Becker, ...
Front Biosci (Landmark Ed) 22, 21-47, 2017
102017
Combinations of inhibitors of irak4 with inhibitors of btk
U Bothe, AM Wengner, H Siebeneicher, N Schmidt, R Nubbemeyer, ...
US Patent App. 15/570,212, 2018
92018
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