| New functions of aminoacyl-tRNA synthetases beyond translation M Guo, XL Yang, P Schimmel Nature Reviews Molecular Cell Biology 11 (9), 668-674, 2010 | 453 | 2010 |
| Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration R Ishimura, G Nagy, I Dotu, H Zhou, XL Yang, P Schimmel, S Senju, ... Science 345 (6195), 455-459, 2014 | 437 | 2014 |
| Structural studies of atom-specific anticancer drugs acting on DNA XL Yang, AHJ Wang Pharmacology & therapeutics 83 (3), 181-215, 1999 | 299 | 1999 |
| Functional expansion of human tRNA synthetases achieved by structural inventions M Guo, P Schimmel, XL Yang FEBS letters 584 (2), 434-442, 2010 | 219 | 2010 |
| Crystal structure of a human aminoacyl-tRNA synthetase cytokine XL Yang, RJ Skene, DE McRee, P Schimmel Proceedings of the National Academy of Sciences 99 (24), 15369-15374, 2002 | 197 | 2002 |
| Long-range structural effects of a Charcot–Marie–Tooth disease-causing mutation in human glycyl-tRNA synthetase W Xie, LA Nangle, W Zhang, P Schimmel, XL Yang Proceedings of the National Academy of Sciences 104 (24), 9976-9981, 2007 | 193 | 2007 |
| Charcot–Marie–Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect LA Nangle, W Zhang, W Xie, XL Yang, P Schimmel Proceedings of the National Academy of Sciences 104 (27), 11239-11244, 2007 | 179 | 2007 |
| ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase H Zhou, L Sun, XL Yang, P Schimmel Nature 494 (7435), 121-124, 2013 | 173 | 2013 |
| Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality Q Zhou, M Kapoor, M Guo, R Belani, X Xu, WB Kiosses, M Hanan, C Park, ... Nature structural & molecular biology 17 (1), 57-61, 2010 | 168 | 2010 |
| Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis MC Park, T Kang, D Jin, JM Han, SB Kim, YJ Park, K Cho, YW Park, ... Proceedings of the National Academy of Sciences 109 (11), E640-E647, 2012 | 157 | 2012 |
| CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase W He, G Bai, H Zhou, N Wei, MN White, J Lauer, H Liu, Y Shi, CD Dumitru, ... Nature 526, 710-714, 2015 | 156 | 2015 |
| Exome sequencing identifies a significant variant in methionyl-tRNA synthetase (MARS) in a family with late-onset CMT2 M Gonzalez, H McLaughlin, H Houlden, M Guo, L Yo-Tsen, ... Journal of Neurology, Neurosurgery & Psychiatry 84 (11), 1247-1249, 2013 | 149 | 2013 |
| Structural switch of lysyl-tRNA synthetase between translation and transcription Y Ofir-Birin, P Fang, SP Bennett, HM Zhang, J Wang, I Rachmin, ... Molecular cell 49 (1), 30-42, 2013 | 149 | 2013 |
| The novel fragment of tyrosyl tRNA synthetase, mini-TyrRS, is secreted to induce an angiogenic response in endothelial cells Y Greenberg, M King, WB Kiosses, K Ewalt, X Yang, P Schimmel, ... The FASEB Journal 22 (5), 1597-1605, 2008 | 148 | 2008 |
| Charcot-Marie-Tooth–linked mutant GARS is toxic to peripheral neurons independent of wild-type GARS levels WW Motley, KL Seburn, MH Nawaz, KE Miers, J Cheng, A Antonellis, ... PLoS genetics 7 (12), e1002399, 2011 | 130 | 2011 |
| Human tRNA synthetase catalytic nulls with diverse functions WS Lo, E Gardiner, Z Xu, CF Lau, F Wang, JJ Zhou, JD Mendlein, ... science 345 (6194), 328-332, 2014 | 129 | 2014 |
| Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot–Marie–Tooth neuropathy E Storkebaum, R Leitão-Gonçalves, T Godenschwege, L Nangle, M Mejia, ... Proceedings of the National Academy of Sciences 106 (28), 11782-11787, 2009 | 129 | 2009 |
| Impaired protein translation in Drosophila models for Charcot–Marie–Tooth neuropathy caused by mutant tRNA synthetases S Niehues, J Bussmann, G Steffes, I Erdmann, C Köhrer, L Sun, ... Nature communications 6 (1), 1-13, 2015 | 127 | 2015 |
| Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma M Guo, YE Chong, R Shapiro, K Beebe, XL Yang, P Schimmel Nature 462 (7274), 808-812, 2009 | 118 | 2009 |
| Gain-of-function mutational activation of human tRNA synthetase procytokine XL Yang, M Kapoor, FJ Otero, BM Slike, H Tsuruta, R Frausto, A Bates, ... Chemistry & biology 14 (12), 1323-1333, 2007 | 117 | 2007 |
