| Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors M Schütte, T Risch, N Abdavi-Azar, K Boehnke, D Schumacher, M Keil, ... Nature communications 8 (1), 14262, 2017 | 300 | 2017 |
| Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity C Ballaré, M Lange, A Lapinaite, GM Martin, L Morey, G Pascual, R Liefke, ... Nature structural & molecular biology 19 (12), 1257-1265, 2012 | 271 | 2012 |
| Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex M Lange, B Kaynak, UB Forster, M Tönjes, JJ Fischer, C Grimm, ... Genes & development 22 (17), 2370-2384, 2008 | 264 | 2008 |
| The cardiac transcription network modulated by Gata4, Mef2a, Nkx2. 5, Srf, histone modifications, and microRNAs J Schlesinger, M Schueler, M Grunert, JJ Fischer, Q Zhang, T Krueger, ... PLoS genetics 7 (2), e1001313, 2011 | 251 | 2011 |
| Assay establishment and validation of a high-throughput screening platform for three-dimensional patient-derived colon cancer organoid cultures K Boehnke, PW Iversen, D Schumacher, MJ Lallena, R Haro, J Amat, ... Journal of biomolecular screening 21 (9), 931-941, 2016 | 147 | 2016 |
| Simultaneous inhibition of PI3Kδ and PI3Kα induces ABC-DLBCL regression by blocking BCR-dependent and-independent activation of NF-κB and AKT J Paul, M Soujon, AM Wengner, S Zitzmann-Kolbe, A Sturz, K Haike, ... Cancer cell 31 (1), 64-78, 2017 | 144 | 2017 |
| Non-canonical hedgehog signaling is a positive regulator of the WNT pathway and is required for the survival of colon cancer stem cells JL Regan, D Schumacher, S Staudte, A Steffen, J Haybaeck, U Keilholz, ... Cell reports 21 (10), 2813-2828, 2017 | 125 | 2017 |
| Characterization of TBX20 in human hearts and its regulation by TFAP2 S Hammer, M Toenjes, M Lange, JJ Fischer, I Dunkel, S Mebus, ... Journal of cellular biochemistry 104 (3), 1022-1033, 2008 | 69 | 2008 |
| Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer SM Dieter, C Siegl, PL Codó, M Huerta, AL Ostermann-Parucha, E Schulz, ... Cell reports 36 (3), 2021 | 46 | 2021 |
| Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase CW Garvie, X Wu, M Papanastasiou, S Lee, J Fuller, GR Schnitzler, ... Nature Communications 12 (1), 4375, 2021 | 43 | 2021 |
| A tyrosine-rich domain within homeodomain transcription factor Nkx2-5 is an essential element in the early cardiac transcriptional regulatory machinery DA Elliott, MJ Solloway, N Wise, C Biben, MW Costa, MB Furtado, ... Oxford University Press for The Company of Biologists Limited 133 (7), 1311-1322, 2006 | 39 | 2006 |
| Depression of transcription and translation during daily torpor in the Djungarian hamster (Phodopus sungorus) M Berriel Diaz, M Lange, G Heldmaier, M Klingenspor Journal of Comparative Physiology B 174, 495-502, 2004 | 38 | 2004 |
| PDE5 inhibition eliminates cancer stem cells via induction of PKA signaling S Klutzny, A Anurin, B Nicke, JL Regan, M Lange, L Schulze, K Parczyk, ... Cell Death & Disease 9 (2), 192, 2018 | 35 | 2018 |
| PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3 HR Chung, C Xu, A Fuchs, A Mund, M Lange, H Staege, T Schubert, ... Elife 5, e10607, 2016 | 33 | 2016 |
| Copanlisib synergizes with conventional and targeted agents including venetoclax in B-and T-cell lymphoma models C Tarantelli, M Lange, E Gaudio, L Cascione, F Spriano, I Kwee, ... Blood advances 4 (5), 819-829, 2020 | 31 | 2020 |
| Indazolecarboxamides, processes for their preparation, pharmaceutical preparations comprising them and their use for producing medicaments U Bothe, H Siebeneicher, N Schmidt, A Rotgeri, U Bömer, S Ring, ... US Patent 9,951,086, 2018 | 30 | 2018 |
| Combinatorial assembly and function of chromatin regulatory complexes M Lange, S Demajo, P Jain, L Di Croce Epigenomics 3 (5), 567-580, 2011 | 30 | 2011 |
| Identification of small molecules that modulate mutant p53 condensation C Lemos, L Schulze, J Weiske, H Meyer, N Braeuer, N Barak, ... Iscience 23 (9), 2020 | 29 | 2020 |
| Setting and resetting of epigenetic marks in malignant transformation and development H Richly, M Lange, E Simboeck, L Di Croce Bioessays 32 (8), 669-679, 2010 | 26 | 2010 |
| The Polycomb-associated factor PHF19 controls hematopoietic stem cell state and differentiation P Vizán, A Gutiérrez, I Espejo, M García-Montolio, M Lange, A Carretero, ... Science advances 6 (32), eabb2745, 2020 | 24 | 2020 |
Silke R. SperlingProfessor for Cardiovascular Genetics, Charité - University Medicine BerlinVerified email at charite.de
