Lars Johannesen
Lars Johannesen
PhD student and Research fellow at FDA and Karolinska Institutet
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An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel
WJ Crumb Jr, J Vicente, L Johannesen, DG Strauss
Journal of pharmacological and toxicological methods 81, 251-262, 2016
Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias
K Blinova, J Stohlman, J Vicente, D Chan, L Johannesen, ...
Toxicological Sciences 155 (1), 234-247, 2017
Differentiating Drug‐Induced Multichannel Block on the Electrocardiogram: Randomized Study of Dofetilide, Quinidine, Ranolazine, and Verapamil
L Johannesen, J Vicente, JW Mason, C Sanabria, K Waite‐Labott, ...
Clinical Pharmacology & Therapeutics 96 (5), 549-558, 2014
Results From the IQ‐CSRC Prospective Study Support Replacement of the Thorough QT Study by QT Assessment in the Early Clinical Phase
B Darpo, C Benson, C Dota, G Ferber, C Garnett, CL Green, V Jarugula, ...
Clinical Pharmacology & Therapeutics 97 (4), 326-335, 2015
Late sodium current block for drug‐induced long QT syndrome: Results from a prospective clinical trial
L Johannesen, J Vicente, JW Mason, C Erato, C Sanabria, K Waite‐Labott, ...
Clinical Pharmacology & Therapeutics 99 (2), 214-223, 2016
Comprehensive T wave Morphology Assessment in a Randomized Clinical Study of Dofetilide, Quinidine, Ranolazine, and Verapamil
J Vicente, L Johannesen, JW Mason, WJ Crumb, E Pueyo, N Stockbridge, ...
Journal of the American Heart Association 4 (4), e001615, 2015
Common Genetic Variant Risk Score Is Associated With Drug-Induced QT Prolongation and Torsade de Pointes Risk
DG Strauss, J Vicente, L Johannesen, K Blinova, JW Mason, P Weeke, ...
Circulation 135 (14), 1300-1310, 2017
Mechanistic Model‐Informed Proarrhythmic Risk Assessment of Drugs: Review of the “CiPA” Initiative and Design of a Prospective Clinical Validation Study
J Vicente, R Zusterzeel, L Johannesen, J Mason, P Sager, V Patel, ...
Clinical Pharmacology & Therapeutics 103 (1), 54-66, 2018
The IQ‐CSRC Prospective Clinical Phase 1 Study:“Can Early QT Assessment Using Exposure Response Analysis Replace the Thorough QT Study?”
B Darpo, N Sarapa, C Garnett, C Benson, C Dota, G Ferber, V Jarugula, ...
Annals of Noninvasive Electrocardiology 19 (1), 70-81, 2014
Improving the assessment of heart toxicity for all new drugs through translational regulatory science
L Johannesen, J Vicente, RA Gray, L Galeotti, Z Loring, CE Garnett, ...
Clinical Pharmacology & Therapeutics 95 (5), 501-508, 2014
Mechanisms of sex and age differences in ventricular repolarization in humans
J Vicente, L Johannesen, L Galeotti, DG Strauss
American heart journal 168 (5), 749-756. e3, 2014
Automatic ECG quality scoring methodology: mimicking human annotators
L Johannesen, L Galeotti
Physiological Measurement 33 (9), 1479, 2012
Assessment of Multi‐Ion Channel Block in a Phase I Randomized Study Design: Results of the Ci PA Phase I ECG Biomarker Validation Study
J Vicente, R Zusterzeel, L Johannesen, R Ochoa‐Jimenez, JW Mason, ...
Clinical Pharmacology & Therapeutics 105 (4), 943-953, 2019
A Comparison of IIR and Wavelet Filtering for Noise Reduction of the ECG
JS Sørensen, L Johannesen, USL Grove, K Lundhus, JP Couderc, C Graff
Computing in Cardiology, 2010, 489-492, 2010
Assessment of ECG quality on an android platform
L Johannesen
Computing in Cardiology 38, 433-436, 2011
Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block
J Vicente, L Johannesen, M Hosseini, JW Mason, PT Sager, E Pueyo, ...
PLOS ONE 11 (12), e0163619, 2016
Automated Algorithm for J-Tpeak and Tpeak-Tend Assessment of Drug-Induced Proarrhythmia Risk
L Johannesen, J Vicente, M Hosseini, DG Strauss
PLOS ONE 11 (12), e0166925, 2016
Assessing ECG signal quality indices to discriminate ECGs with artefacts from pathologically different arrhythmic ECGs
C Daluwatte, L Johannesen, L Galeotti, J Vicente, DG Strauss, CG Scully
Physiological Measurement 37 (8), 1370, 2016
Universal correction for QT/RR hysteresis
M Malik, L Johannesen, K Hnatkova, N Stockbridge
Drug safety 39 (6), 577-588, 2016
Heart rate dependency of JT interval sections
K Hnatkova, L Johannesen, J Vicente, M Malik
Journal of electrocardiology 50 (6), 814-824, 2017
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