| Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment N Jura, NF Endres, K Engel, S Deindl, R Das, MH Lamers, DE Wemmer, ... Cell 137 (7), 1293-1307, 2009 | 697 | 2009 |
| Architecture and Membrane Interactions of the EGF Receptor A Arkhipov, Y Shan, R Das, NF Endres, MP Eastwood, DE Wemmer, ... Cell 152 (3), 557-569, 2013 | 560 | 2013 |
| Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor NF Endres, R Das, AW Smith, A Arkhipov, E Kovacs, Y Huang, JG Pelton, ... Cell 152 (3), 543-556, 2013 | 537 | 2013 |
| cAMP activation of PKA defines an ancient signaling mechanism R Das, V Esposito, M Abu-Abed, GS Anand, SS Taylor, G Melacini Proceedings of the National Academy of Sciences 104 (1), 93, 2007 | 160 | 2007 |
| Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting R Pathania, S Zlitni, C Barker, R Das, DA Gerritsma, J Lebert, E Awuah, ... Nature chemical biology 5 (11), 849-856, 2009 | 142 | 2009 |
| Understanding the molecular basis for the inhibition of the Alzheimer's Aβ-peptide oligomerization by human serum albumin using saturation transfer difference and off-resonance … J Milojevic, V Esposito, R Das, G Melacini Journal of the American Chemical Society 129 (14), 4282-4290, 2007 | 139 | 2007 |
| Regulation of the catalytic activity of the EGF receptor NF Endres, K Engel, R Das, E Kovacs, J Kuriyan Current opinion in structural biology 21 (6), 777-784, 2011 | 120 | 2011 |
| Analysis of the role of the C-terminal tail in the regulation of the epidermal growth factor receptor E Kovacs, R Das, Q Wang, TS Collier, A Cantor, Y Huang, K Wong, ... Molecular and cellular biology 35 (17), 3083-3102, 2015 | 102 | 2015 |
| The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants R Selvaratnam, B VanSchouwen, F Fogolari, MT Mazhab-Jafari, R Das, ... Biophysical journal 102 (3), 630-639, 2012 | 96 | 2012 |
| Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1 JS Iwig, Y Vercoulen, R Das, T Barros, A Limnander, Y Che, JG Pelton, ... Elife 2, e00813, 2013 | 91 | 2013 |
| Dynamically driven ligand selectivity in cyclic nucleotide binding domains R Das, S Chowdhury, MT Mazhab-Jafari, S SilDas, R Selvaratnam, ... Journal of Biological Chemistry 284 (35), 23682-23696, 2009 | 91 | 2009 |
| The auto-inhibitory role of the EPAC hinge helix as mapped by NMR R Selvaratnam, MT Mazhab-Jafari, R Das, G Melacini PloS one 7 (11), e48707, 2012 | 85 | 2012 |
| Entropy-driven cAMP-dependent allosteric control of inhibitory interactions in exchange proteins directly activated by cAMP R Das, MT Mazhab-Jafari, S Chowdhury, S SilDas, R Selvaratnam, ... Journal of Biological Chemistry 283 (28), 19691-19703, 2008 | 70 | 2008 |
| Communication between Tandem cAMP Binding Domains in the Regulatory Subunit of Protein Kinase A-Iα as Revealed by Domain-silencing Mutations ET McNicholl, R Das, S SilDas, SS Taylor, G Melacini Journal of Biological Chemistry 285 (20), 15523, 2010 | 62 | 2010 |
| Understanding cAMP-dependent allostery by NMR spectroscopy: comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states MT Mazhab-Jafari, R Das, SA Fotheringham, S SilDas, S Chowdhury, ... Journal of the American Chemical Society 129 (46), 14482-14492, 2007 | 56 | 2007 |
| Mapping allostery through equilibrium perturbation NMR spectroscopy R Das, M Abu-Abed, G Melacini Journal of the American Chemical Society 128 (26), 8406-8407, 2006 | 55 | 2006 |
| Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA CA Barker, SE Allison, S Zlitni, ND Nguyen, R Das, G Melacini, ... Bioorganic & medicinal chemistry letters 23 (8), 2426-2431, 2013 | 54 | 2013 |
| A model for agonism and antagonism in an ancient and ubiquitous cAMP-binding domain R Das, G Melacini Journal of Biological Chemistry 282 (1), 581-593, 2007 | 52 | 2007 |
| Definition of an electrostatic relay switch critical for the cAMP‐dependent activation of protein kinase A as revealed by the D170A mutant of RIα M Abu‐Abed, R Das, L Wang, G Melacini Proteins: Structure, Function, and Bioinformatics 69 (1), 112-124, 2007 | 51 | 2007 |
| A novel protein tyrosine phosphatase like phytase from Lactobacillus fermentum NKN51: cloning, characterization and application in mineral release for food technology applications R Sharma, P Kumar, V Kaushal, R Das, NK Navani Bioresource technology 249, 1000-1008, 2018 | 30 | 2018 |
Giuseppe MelaciniProfessor, McMaster UniversityVerified email at mcmaster.ca
