Sean Devenish
Sean Devenish
Fluidic Analytics
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One in a Million: Flow Cytometric Sorting of Single Cell-Lysate Assays in Monodisperse Picolitre Double Emulsion Droplets for Directed Evolution
A Zinchenko, SRA Devenish, B Kintses, PY Colin, M Fischlechner, ...
Analytical chemistry 86 (5), 2526-2533, 2014
Microfluidic droplets: new integrated workflows for biological experiments
B Kintses, LD van Vliet, SRA Devenish, F Hollfelder
Current opinion in chemical biology 14 (5), 548-555, 2010
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies
S Linse, T Scheidt, K Bernfur, M Vendruscolo, CM Dobson, SIA Cohen, ...
Nature Structural & Molecular Biology 27 (12), 1125-1133, 2020
A Fully Unsupervised Compartment-on-Demand Platform for Precise Nanoliter Assays of Time-Dependent Steady-State Enzyme Kinetics and Inhibition
F Gielen, L van Vliet, BT Koprowski, SRA Devenish, M Fischlechner, ...
Analytical chemistry 85 (9), 4761-4769, 2013
Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis
G Kefala, GL Evans, MDW Griffin, SRA Devenish, FG Pearce, MA Perugini, ...
Biochemical Journal 411 (2), 351-360, 2008
Inhibiting dihydrodipicolinate synthase across species: Towards specificity for pathogens?
V Mitsakos, RCJ Dobson, FG Pearce, SR Devenish, GL Evans, ...
Bioorganic & medicinal chemistry letters 18 (2), 842-844, 2008
Role of arginine 138 in the catalysis and regulation of Escherichia coli dihydrodipicolinate synthase
RCJ Dobson, SRA Devenish, LA Turner, VR Clifford, FG Pearce, ...
Biochemistry 44 (39), 13007-13013, 2005
Accessing unexplored regions of sequence space in directed enzyme evolution via insertion/deletion mutagenesis
S Emond, M Petek, EJ Kay, B Heames, SRA Devenish, N Tokuriki, ...
Nature communications 11 (1), 3469, 2020
On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products
KL Saar, Y Zhang, T Müller, CP Kumar, S Devenish, A Lynn, U Łapińska, ...
Lab on a Chip 18 (1), 162-170, 2018
A single mutation in the core domain of the lac repressor reduces leakiness
P Gatti-Lafranconi, WP Dijkman, SRA Devenish, F Hollfelder
Microb. Cell Fact 12 (67.10), 1186, 2013
Dual side-reactions limit the utility of a key polymer therapeutic precursor
SRA Devenish, JB Hill, JW Blunt, JC Morris, MHG Munro
Tetrahedron letters 47 (17), 2875-2878, 2006
How essential is the ‘essential’active-site lysine in dihydrodipicolinate synthase?
TPS da Costa, AC Muscroft-Taylor, RCJ Dobson, SRA Devenish, ...
Biochimie 92 (7), 837-845, 2010
Conserved main‐chain peptide distortions: A proposed role for Ile203 in catalysis by dihydrodipicolinate synthase
RCJ Dobson, MDW Griffin, SRA Devenish, FG Pearce, CA Hutton, ...
Protein Science 17 (12), 2080-2090, 2008
A simple method to evaluate the biochemical compatibility of oil/surfactant mixtures for experiments in microdroplets
M Kaltenbach, SRA Devenish, F Hollfelder
Lab on a Chip 12 (20), 4185-4192, 2012
Cloning and characterisation of dihydrodipicolinate synthase from the pathogen Neisseria meningitidis
SRA Devenish, FHA Huisman, EJ Parker, AT Hadfield, JA Gerrard
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1794 (8), 1168-1174, 2009
NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase
SRA Devenish, JW Blunt, JA Gerrard
Journal of medicinal chemistry 53 (12), 4808-4812, 2010
Characterisation of dihydrodipicolinate synthase (DHDPS) from Bacillus anthracis
LJ Domigan, SW Scally, MJ Fogg, CA Hutton, MA Perugini, RCJ Dobson, ...
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1794 (10), 1510-1516, 2009
The role of quaternary structure in (β/α) 8-barrel proteins: evolutionary happenstance or a higher level of structure-function relationships?
SRA Devenish, JA Gerrard
Organic & biomolecular chemistry 7 (5), 833-839, 2009
The high-resolution structure of dihydrodipicolinate synthase from Escherichia coli bound to its first substrate, pyruvate
SRA Devenish, JA Gerrard, GB Jameson, RCJ Dobson
Acta Crystallographica Section F: Structural Biology and Crystallization …, 2008
Antibody affinity governs the inhibition of SARS-CoV-2 spike/ACE2 binding in patient serum
S Fiedler, MA Piziorska, V Denninger, AS Morgunov, A Ilsley, AY Malik, ...
ACS infectious diseases 7 (8), 2362-2369, 2021
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