| Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases JR Somoza, RJ Skene, BA Katz, C Mol, JD Ho, AJ Jennings, C Luong, ... Structure 12 (7), 1325-1334, 2004 | 845 | 2004 |
| Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein K Aertgeerts, R Skene, J Yano, BC Sang, H Zou, G Snell, A Jennings, ... Journal of Biological Chemistry 286 (21), 18756-18765, 2011 | 404 | 2011 |
| High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875 A Srivastava, J Yano, Y Hirozane, G Kefala, F Gruswitz, G Snell, W Lane, ... Nature 513 (7516), 124-127, 2014 | 388 | 2014 |
| Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl) benzamides JC Bressi, AJ Jennings, R Skene, Y Wu, R Melkus, R De Jong, ... Bioorganic & medicinal chemistry letters 20 (10), 3142-3145, 2010 | 311 | 2010 |
| Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein α K Aertgeerts, I Levin, L Shi, GP Snell, A Jennings, GS Prasad, Y Zhang, ... Journal of Biological Chemistry 280 (20), 19441-19444, 2005 | 304 | 2005 |
| A Novel, Potent, and Selective 5-HT7 Antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970) PJ Lovell, SM Bromidge, S Dabbs, DM Duckworth, IT Forbes, AJ Jennings, ... Journal of medicinal chemistry 43 (3), 342-345, 2000 | 288 | 2000 |
| Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression L Lama, C Adura, W Xie, D Tomita, T Kamei, V Kuryavyi, T Gogakos, ... Nature Communications 10 (1), 2261, 2019 | 183 | 2019 |
| Design and synthesis of pyrimidinone and pyrimidinedione inhibitors of dipeptidyl peptidase IV Z Zhang, MB Wallace, J Feng, JA Stafford, RJ Skene, L Shi, B Lee, ... Journal of medicinal chemistry 54 (2), 510-524, 2011 | 152 | 2011 |
| (R)-3,N-Dimethyl-N-[1-methyl-3-(4-methylpiperidin-1-yl)propyl]benzenesulfonamide: The First Selective 5-HT7 Receptor Antagonist IT Forbes, S Dabbs, DM Duckworth, AJ Jennings, FD King, PJ Lovell, ... Journal of medicinal chemistry 41 (5), 655-657, 1998 | 139 | 1998 |
| Conformational flexibility in crystal structures of human 11β-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation DJ Hosfield, Y Wu, RJ Skene, M Hilgers, A Jennings, GP Snell, ... Journal of Biological Chemistry 280 (6), 4639-4648, 2005 | 125 | 2005 |
| The Selective 5-HT1B Receptor Inverse Agonist 1 ‘-Methyl-5-[[2 ‘-methyl-4 ‘-(5-methyl-1, 2, 4-oxadiazol-3-yl) biphenyl-4-yl] carbonyl]-2, 3, 6, 7-tetrahydro-spiro [furo [2, 3-f … LM Gaster, FE Blaney, S Davies, DM Duckworth, P Ham, S Jenkins, ... Journal of medicinal chemistry 41 (8), 1218-1235, 1998 | 98 | 1998 |
| Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2, 5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134) SM Bromidge, SE Clarke, T Gager, K Griffith, P Jeffrey, AJ Jennings, ... Bioorganic & medicinal chemistry letters 11 (1), 55-58, 2001 | 76 | 2001 |
| Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK) B Lam, Y Arikawa, J Cramlett, Q Dong, R de Jong, V Feher, CE Grimshaw, ... Bioorganic & medicinal chemistry letters 26 (24), 5947-5950, 2016 | 69 | 2016 |
| Selection of molecules based on shape and electrostatic similarity: proof of concept of “electroforms” A Jennings, M Tennant Journal of chemical information and modeling 47 (5), 1829-1838, 2007 | 68 | 2007 |
| Histone deacetylase inhibitors J Bressi, A Gangloff, A Jennings US Patent App. 11/013,234, 2005 | 63 | 2005 |
| Histone deacetylase inhibitors JC Bressi, JW Brown, SX Cao, AR Gangloff, AJ Jennings, JA Stafford, ... US Patent 7,169,801, 2007 | 61 | 2007 |
| Benzimidazole and imidazole inhibitors of histone deacetylases: synthesis and biological activity JC Bressi, R de Jong, Y Wu, AJ Jennings, JW Brown, S O’Connell, ... Bioorganic & medicinal chemistry letters 20 (10), 3138-3141, 2010 | 58 | 2010 |
| Amide and urea derivatives as 5HT1D receptor antagonists DM Duckworth, LM Gaster, SM Jenkins, AJ Jennings, KR Mulholland US Patent 5,905,080, 1999 | 58 | 1999 |
| Trelagliptin (SYR-472, Zafatek), novel once-weekly treatment for type 2 diabetes, inhibits dipeptidyl peptidase-4 (DPP-4) via a non-covalent mechanism CE Grimshaw, A Jennings, R Kamran, H Ueno, N Nishigaki, T Kosaka, ... PLoS One 11 (6), e0157509, 2016 | 54 | 2016 |
| An approach to improving multiple alignments of protein sequences using predicted secondary structure AJ Jennings, CM Edge, MJE Sternberg Protein Engineering 14 (4), 227-231, 2001 | 51 | 2001 |
