| Carbonic anhydrase generates CO2 and H+ that drive spider silk formation via opposite effects on the terminal domains M Andersson, G Chen, M Otikovs, M Landreh, K Nordling, N Kronqvist, ... PLoS biology 12 (8), e1001921, 2014 | 198 | 2014 |
| Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk formation N Kronqvist, M Otikovs, V Chmyrov, G Chen, M Andersson, K Nordling, ... Nature communications 5 (1), 3254, 2014 | 167 | 2014 |
| Full-length minor ampullate spidroin gene sequence G Chen, X Liu, Y Zhang, S Lin, Z Yang, J Johansson, A Rising, Q Meng PLoS One 7 (12), e52293, 2012 | 106 | 2012 |
| Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state G Chen, A Abelein, HE Nilsson, A Leppert, Y Andrade-Talavera, ... Nature communications 8 (1), 2081, 2017 | 83 | 2017 |
| TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro H Balleza-Tapia, S Crux, Y Andrade-Talavera, P Dolz-Gaiton, D Papadia, ... Elife 7, e37703, 2018 | 72 | 2018 |
| TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro H Balleza-Tapia, S Crux, Y Andrade-Talavera, P Dolz-Gaiton, D Papadia, ... Elife 7, e37703, 2018 | 72 | 2018 |
| Dementia-related Bri2 BRICHOS is a versatile molecular chaperone that efficiently inhibits Aβ42 toxicity in Drosophila H Poska, M Haslbeck, FR Kurudenkandy, E Hermansson, G Chen, ... Biochemical journal 473 (20), 3683-3704, 2016 | 56 | 2016 |
| High-yield production of amyloid-β peptide enabled by a customized spider silk domain A Abelein, G Chen, K Kitoka, R Aleksis, F Oleskovs, M Sarr, M Landreh, ... Scientific reports 10 (1), 235, 2020 | 55 | 2020 |
| Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro G Chen, Y Andrade-Talavera, S Tambaro, A Leppert, HE Nilsson, ... Communications Biology 3 (1), 32, 2020 | 50 | 2020 |
| Diversified Structural Basis of a Conserved Molecular Mechanism for pH‐Dependent Dimerization in Spider Silk N‐Terminal Domains M Otikovs, G Chen, K Nordling, M Landreh, Q Meng, H Jörnvall, ... Chembiochem 16 (12), 1720-1724, 2015 | 43 | 2015 |
| A spidroin‐derived solubility tag enables controlled aggregation of a designed amyloid protein M Sarr, N Kronqvist, G Chen, R Aleksis, P Purhonen, H Hebert, ... The FEBS Journal 285 (10), 1873-1885, 2018 | 39 | 2018 |
| Modulation of Kv3.1/Kv3.2 promotes gamma oscillations by rescuing Aβ‐induced desynchronization of fast‐spiking interneuron firing in an AD mouse model in vitro Y Andrade‐Talavera, LE Arroyo‐García, G Chen, J Johansson, A Fisahn The Journal of Physiology 598 (17), 3711-3725, 2020 | 30 | 2020 |
| Intravenous treatment with a molecular chaperone designed against β-amyloid toxicity improves Alzheimer’s disease pathology in mouse models S Manchanda, L Galan-Acosta, A Abelein, S Tambaro, G Chen, P Nilsson, ... Molecular Therapy 31 (2), 487-502, 2023 | 22 | 2023 |
| Blood–brain and blood–cerebrospinal fluid passage of BRICHOS domains from two molecular chaperones in mice S Tambaro, L Galan-Acosta, A Leppert, G Chen, H Biverstål, J Presto, ... Journal of Biological Chemistry 294 (8), 2606-5220, 2019 | 20 | 2019 |
| High intracellular stability of the spidroin N‐terminal domain in spite of abundant amyloidogenic segments revealed by in‐cell hydrogen/deuterium exchange mass spectrometry M Kaldmäe, A Leppert, G Chen, M Sarr, C Sahin, K Nordling, N Kronqvist, ... The FEBS Journal 287 (13), 2823-2833, 2020 | 19 | 2020 |
| Recombinant Bri3 BRICHOS domain is a molecular chaperone with effect against amyloid formation and non-fibrillar protein aggregation H Poska, A Leppert, H Tigro, X Zhong, M Kaldmäe, HE Nilsson, H Hebert, ... Scientific reports 10 (1), 9817, 2020 | 18 | 2020 |
| Chimeric spider silk proteins mediated by intein result in artificial hybrid silks S Lin, G Chen, X Liu, Q Meng Biopolymers 105 (7), 385-392, 2016 | 16 | 2016 |
| Amyloid fibril formation of Arctic amyloid-β 1–42 peptide is efficiently inhibited by the BRICHOS domain X Zhong, R Kumar, Y Wang, H Biverstål, C Ingeborg Jegerschöld, ... ACS Chemical Biology 17 (8), 2201-2211, 2022 | 15 | 2022 |
| Customized flagelliform spidroins form spider silk-like fibers at pH 8.0 with outstanding tensile strength X Li, X Qi, Y Cai, Y Sun, R Wen, R Zhang, J Johansson, Q Meng, G Chen ACS Biomaterials Science & Engineering 8 (1), 119-127, 2021 | 14 | 2021 |
| Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue G Chen, Y Andrade-Talavera, X Zhong, S Hassan, H Biverstål, H Poska, ... RSC chemical biology 3 (11), 1342-1358, 2022 | 13 | 2022 |
