| Bicyclic boronate VNRX-5133 inhibits metallo-and serine-β-lactamases A Krajnc, J Brem, P Hinchliffe, K Calvopiña, TD Panduwawala, PA Lang, ... Journal of Medicinal Chemistry 62 (18), 8544-8556, 2019 | 168 | 2019 |
| Will morphing boron-based inhibitors beat the β-lactamases? A Krajnc, PA Lang, TD Panduwawala, J Brem, CJ Schofield Current Opinion in Chemical Biology 50, 101-110, 2019 | 82 | 2019 |
| Molecular basis of class A β-lactamase inhibition by relebactam CL Tooke, P Hinchliffe, PA Lang, AJ Mulholland, J Brem, CJ Schofield, ... Antimicrobial agents and chemotherapy 63 (10), 10.1128/aac. 00564-19, 2019 | 57 | 2019 |
| Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors J Brem, T Panduwawala, JU Hansen, J Hewitt, E Liepins, P Donets, ... Nature Chemistry 14 (1), 15-24, 2022 | 44 | 2022 |
| An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography A Butryn, PS Simon, P Aller, P Hinchliffe, RN Massad, G Leen, CL Tooke, ... Nature communications 12 (1), 4461, 2021 | 38 | 2021 |
| Studies on the interaction of the histone demethylase KDM5B with tricarboxylic acid cycle intermediates H Tarhonskaya, RP Nowak, C Johansson, A Szykowska, A Tumber, ... Journal of Molecular Biology 429 (19), 2895-2906, 2017 | 38 | 2017 |
| Mapping the Hydrophobic Substrate Binding Site of Phenylalanine Ammonia-Lyase from Petroselinum crispum EZA Nagy, SD Tork, PA Lang, A Filip, FD Irimie, L Poppe, MI Toşa, ... ACS Catalysis 9 (9), 8825-8834, 2019 | 33 | 2019 |
| X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis P Rabe, JJAG Kamps, KD Sutherlin, JDS Linyard, P Aller, CC Pham, ... Science Advances 7 (34), eabh0250, 2021 | 31 | 2021 |
| Targeting the Mycobacterium tuberculosis transpeptidase Ldt Mt2 with cysteine-reactive inhibitors including ebselen M de Munnik, CT Lohans, PA Lang, GW Langley, TR Malla, A Tumber, ... Chemical communications 55 (69), 10214-10217, 2019 | 28 | 2019 |
| Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli PA Lang, A Parkova, TM Leissing, K Calvopiña, R Cain, A Krajnc, ... Biomolecules 10 (6), 899, 2020 | 23 | 2020 |
| Anaerobic fixed-target serial crystallography P Rabe, JH Beale, A Butryn, P Aller, A Dirr, PA Lang, DN Axford, SB Carr, ... IUCrJ 7 (5), 901-912, 2020 | 15 | 2020 |
| Structural investigations of the inhibition of Escherichia coli AmpC β-lactamase by diazabicyclooctanes PA Lang, TM Leissing, MGP Page, CJ Schofield, J Brem Antimicrobial Agents and Chemotherapy 65 (2), 10.1128/aac. 02073-20, 2021 | 9 | 2021 |
| Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors PA Lang, R Raj, A Tumber, CT Lohans, P Rabe, CV Robinson, J Brem, ... Proceedings of the National Academy of Sciences 119 (18), e2117310119, 2022 | 6 | 2022 |
| Pretargeted PET Imaging with a TCO-Conjugated Anti-CD44v6 Chimeric mAb U36 and [89Zr]Zr-DFO-PEG5-Tz D Lumen, D Vugts, M Chomet, S Imlimthan, M Sarparanta, R Vos, ... Bioconjugate chemistry 33 (5), 956-968, 2022 | 6 | 2022 |
| High-throughput screen with the l, d-transpeptidase Ldt Mt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors M de Munnik, PA Lang, FDD Anton, M Cacho, RH Bates, J Brem, ... Chemical Science 14 (26), 7262-7278, 2023 | 3 | 2023 |
| Biochemical and biophysical studies on the Escherichia coli AmpC β-Lactamase PA Lang University of Oxford, 2022 | | 2022 |
