| Phospho-MurNAc-pentapeptide translocase (MraY) as a target for antibacterial agents and antibacterial proteins TDH Bugg, AJ Lloyd, DI Roper Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious …, 2006 | 166 | 2006 |
| IFN-γ enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2 S Tötemeyer, M Sheppard, A Lloyd, D Roper, C Dowson, D Underhill, ... The Journal of Immunology 176 (8), 4804-4810, 2006 | 109 | 2006 |
| Crystal Structure of Penicillin Binding Protein 4 (dacB) from Escherichia coli, both in the Native Form and Covalently Linked to Various Antibiotics H Kishida, S Unzai, DI Roper, A Lloyd, SY Park, JRH Tame Biochemistry 45 (3), 783-792, 2006 | 105 | 2006 |
| Phospho-N-Acetyl-Muramyl-Pentapeptide Translocase from Escherichia coli: Catalytic Role of Conserved Aspartic Acid Residues AJ Lloyd, PE Brandish, AM Gilbey, TDH Bugg Journal of bacteriology 186 (6), 1747-1757, 2004 | 103 | 2004 |
| Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan AJ Lloyd, AM Gilbey, AM Blewett, G De Pascale, A El Zoeiby, ... Journal of biological chemistry 283 (10), 6402-6417, 2008 | 96 | 2008 |
| Inhibition of D-Ala: D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine S Batson, C de Chiara, V Majce, AJ Lloyd, S Gobec, D Rea, V Fülöp, ... Nature communications 8 (1), 1939, 2017 | 79 | 2017 |
| A broadly applicable continuous spectrophotometric assay for measuring aminoacyl-tRNA synthetase activity AJ Lloyd, HU Thomann, M Ibba, D Soöll Nucleic acids research 23 (15), 2886-2892, 1995 | 74 | 1995 |
| Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase LJ Alderwick, GS Lloyd, AJ Lloyd, AL Lovering, L Eggeling, GS Besra Glycobiology 21 (4), 410-425, 2011 | 55 | 2011 |
| Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis V Usha, SS Gurcha, AL Lovering, AJ Lloyd, A Papaemmanouil, ... Microbiology 157 (1), 290-299, 2011 | 49 | 2011 |
| Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity J Zuegg, C Muldoon, G Adamson, D McKeveney, G Le Thanh, R Premraj, ... Nature communications 6 (1), 7719, 2015 | 48 | 2015 |
| Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB) M Sova, G Čadež, S Turk, V Majce, S Polanc, S Batson, AJ Lloyd, ... Bioorganic & Medicinal Chemistry Letters 19 (5), 1376-1379, 2009 | 46 | 2009 |
| Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF C Paradis-Bleau, A Lloyd, F Sanschagrin, T Clarke, A Blewett, TDH Bugg, ... BMC biochemistry 9, 1-11, 2008 | 46 | 2008 |
| A de novo designed inhibitor of D-Ala-D-Ala ligase from E. coli GE Besong, JM Bostock, W Stubbings, I Chopra, DI Roper, AJ Lloyd, ... Angewandte Chemie (International Edition) 44 (39), 6403-6406, 2005 | 44 | 2005 |
| Specificity determinants for lysine incorporation in Staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex KM Ruane, AJ Lloyd, V Fülöp, CG Dowson, H Barreteau, A Boniface, ... Journal of Biological Chemistry 288 (46), 33439-33448, 2013 | 43 | 2013 |
| A point mutation in Euglena gracilis chloroplast tRNA (Glu) uncouples protein and chlorophyll biosynthesis. N Stange-Thomann, HU Thomann, AJ Lloyd, H Lyman, D Söll Proceedings of the National Academy of Sciences 91 (17), 7947-7951, 1994 | 43 | 1994 |
| Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target SS Gurcha, V Usha, JAG Cox, K Fütterer, KA Abrahams, A Bhatt, ... PloS one 9 (11), e113568, 2014 | 41 | 2014 |
| Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing D-cysteine at position … JA Schouten, S Bagga, AJ Lloyd, G De Pascale, CG Dowson, DI Roper, ... Molecular BioSystems 2 (10), 484-491, 2006 | 39 | 2006 |
| Pseudomonas aeruginosa MurE amide ligase: enzyme kinetics and peptide inhibitor C Paradis-Bleau, A Lloyd, F Sanschagrin, H Maaroufi, T Clarke, A Blewett, ... Biochemical Journal 421 (2), 263-272, 2009 | 37 | 2009 |
| Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme C Paradis-Bleau, M Beaumont, L Boudreault, A Lloyd, F Sanschagrin, ... Peptides 27 (7), 1693-1700, 2006 | 37 | 2006 |
| Refinement of Haemophilus influenzae diaminopimelic acid epimerase (DapF) at 1.75 Å resolution suggests a mechanism for stereocontrol during catalysis AJ Lloyd, T Huyton, J Turkenburg, DI Roper Acta Crystallographica Section D: Biological Crystallography 60 (2), 397-400, 2004 | 32 | 2004 |
