Adrian Lloyd
Adrian Lloyd
Associate Professor
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Cited by
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Phospho-MurNAc-pentapeptide translocase (MraY) as a target for antibacterial agents and antibacterial proteins
TDH Bugg, AJ Lloyd, DI Roper
Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious …, 2006
IFN-γ enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2
S Tötemeyer, M Sheppard, A Lloyd, D Roper, C Dowson, D Underhill, ...
The Journal of Immunology 176 (8), 4804-4810, 2006
Phospho-N-Acetyl-Muramyl-Pentapeptide Translocase from Escherichia coli: Catalytic Role of Conserved Aspartic Acid Residues
AJ Lloyd, PE Brandish, AM Gilbey, TDH Bugg
Journal of bacteriology 186 (6), 1747-1757, 2004
Crystal Structure of Penicillin Binding Protein 4 (dacB) from Escherichia coli, both in the Native Form and Covalently Linked to Various Antibiotics
H Kishida, S Unzai, DI Roper, A Lloyd, SY Park, JRH Tame
Biochemistry 45 (3), 783-792, 2006
Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan
AJ Lloyd, AM Gilbey, AM Blewett, G De Pascale, A El Zoeiby, ...
Journal of Biological Chemistry 283 (10), 6402-6417, 2008
Inhibition of D-Ala: D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine
S Batson, C de Chiara, V Majce, AJ Lloyd, S Gobec, D Rea, V Fülöp, ...
Nature communications 8 (1), 1939, 2017
A broadly applicable continuous spectrophotometric assay for measuring aminoacyl-tRNA synthetase activity
AJ Lloyd, HU Thomann, M Ibba, D Soöll
Nucleic acids research 23 (15), 2886-2892, 1995
Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase
LJ Alderwick, GS Lloyd, AJ Lloyd, AL Lovering, L Eggeling, GS Besra
Glycobiology 21 (4), 410-425, 2011
Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis
V Usha, SS Gurcha, AL Lovering, AJ Lloyd, A Papaemmanouil, ...
Microbiology 157 (1), 290-299, 2011
Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB)
M Sova, G Čadež, S Turk, V Majce, S Polanc, S Batson, AJ Lloyd, ...
Bioorganic & Medicinal Chemistry Letters 19 (5), 1376-1379, 2009
Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF
C Paradis-Bleau, A Lloyd, F Sanschagrin, T Clarke, A Blewett, TDH Bugg, ...
BMC biochemistry 9, 1-11, 2008
Specificity determinants for lysine incorporation in Staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex
KM Ruane, AJ Lloyd, V Fülöp, CG Dowson, H Barreteau, A Boniface, ...
Journal of Biological Chemistry 288 (46), 33439-33448, 2013
Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity
J Zuegg, C Muldoon, G Adamson, D McKeveney, G Le Thanh, R Premraj, ...
Nature communications 6 (1), 7719, 2015
A De Novo Designed Inhibitor of D‐Ala–D‐Ala Ligase from E. coli
GE Besong, JM Bostock, W Stubbings, I Chopra, DI Roper, AJ Lloyd, ...
Angewandte Chemie 117 (39), 6561-6564, 2005
A point mutation in Euglena gracilis chloroplast tRNA (Glu) uncouples protein and chlorophyll biosynthesis.
N Stange-Thomann, HU Thomann, AJ Lloyd, H Lyman, D Söll
Proceedings of the National Academy of Sciences 91 (17), 7947-7951, 1994
Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target
SS Gurcha, V Usha, JAG Cox, K Fütterer, KA Abrahams, A Bhatt, ...
PloS one 9 (11), e113568, 2014
Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing D-cysteine at position …
JA Schouten, S Bagga, AJ Lloyd, G De Pascale, CG Dowson, DI Roper, ...
Molecular BioSystems 2 (10), 484-491, 2006
Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme
C Paradis-Bleau, M Beaumont, L Boudreault, A Lloyd, F Sanschagrin, ...
Peptides 27 (7), 1693-1700, 2006
Pseudomonas aeruginosa MurE amide ligase: enzyme kinetics and peptide inhibitor
C Paradis-Bleau, A Lloyd, F Sanschagrin, H Maaroufi, T Clarke, A Blewett, ...
Biochemical Journal 421 (2), 263-272, 2009
Refinement of Haemophilus influenzae diaminopimelic acid epimerase (DapF) at 1.75 Å resolution suggests a mechanism for stereocontrol during catalysis
AJ Lloyd, T Huyton, J Turkenburg, DI Roper
Acta Crystallographica Section D: Biological Crystallography 60 (2), 397-400, 2004
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