| Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor: STUDY OF Lck-AND FynT-DEPENDENT T CELL ACTIVATION (∗) JH Hanke, JP Gardner, RL Dow, PS Changelian, WH Brissette, ... Journal of Biological Chemistry 271 (2), 695-701, 1996 | 2303 | 1996 |
| Total synthesis of the polyether antibiotic ionomycin DA Evans, RL Dow, TL Shih, JM Takacs, R Zahler Journal of the American Chemical Society 112 (13), 5290-5313, 1990 | 324 | 1990 |
| 4-aminopyrazolo (3-, 4-D) pyrimidine and 4-aminopyrazolo-(3, 4-D) pyridine tyrosine kinase inhibitors RL Dow, K Koch, GR Schulte US Patent 5,593,997, 1997 | 276 | 1997 |
| Aldol addition reactions of chiral crotonate imides DA Evans, EB Sjogren, J Bartroli, RL Dow Tetrahedron letters 27 (41), 4957-4960, 1986 | 183 | 1986 |
| Benzyloxazolidine-2, 4-diones as potent hypoglycemic agents RL Dow, BM Bechle, TT Chou, DA Clark, B Hulin, RW Stevenson Journal of medicinal chemistry 34 (5), 1538-1544, 1991 | 108 | 1991 |
| Cyano containing oxamic acids and derivatives as thyroid receptor ligands RL Dow US Patent 6,194,454, 2001 | 107 | 2001 |
| Hydroxyl-directed hydrogenation of homoallylic alcohols. Effects of achiral and chiral rhodium catalysts on 1, 3 stereocontrol. DA Evans, MM Morrissey, RL Dow Tetrahedron letters 26 (49), 6005-6008, 1985 | 104 | 1985 |
| Discovery of PF-04620110, a potent, selective, and orally bioavailable inhibitor of DGAT-1 RL Dow, JC Li, MP Pence, EM Gibbs, JL LaPerle, J Litchfield, ... ACS medicinal chemistry letters 2 (5), 407-412, 2011 | 97 | 2011 |
| Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent … DA Griffith, JR Hadcock, SC Black, PA Iredale, PA Carpino, ... Journal of medicinal chemistry 52 (2), 234-237, 2009 | 80 | 2009 |
| Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TRβ subtype-selective thyromimetics RL Dow, SR Schneider, ES Paight, RF Hank, P Chiang, P Cornelius, ... Bioorganic & medicinal chemistry letters 13 (3), 379-382, 2003 | 80 | 2003 |
| Cannabinoid receptor ligands and uses thereof RL Dow, M Hammond US Patent 7,247,628, 2007 | 79* | 2007 |
| Identification of tricyclic analogs related to ellagic acid as potent/selective tyrosine protein kinase inhibitors RL Dow, TT Chou, BM Bechle, C Goddard, ER Larson Journal of medicinal chemistry 37 (14), 2224-2231, 1994 | 78 | 1994 |
| Discovery of 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a Novel, Bicyclic … RL Dow, PA Carpino, JR Hadcock, SC Black, PA Iredale, ... Journal of medicinal chemistry 52 (9), 2652-2655, 2009 | 58 | 2009 |
| Cannabinoid receptor ligands and uses thereof PA Carpino, RL Dow US Patent 7,145,012, 2006 | 56 | 2006 |
| β3-Adrenergic agonists: potential therapeutics for obesity RL Dow Expert Opinion on Investigational Drugs 6 (12), 1811-1825, 1997 | 55 | 1997 |
| Medicinal chemistry design principles for liver targeting through OATP transporters M Tu, AM Mathiowetz, JA Pfefferkorn, KO Cameron, RL Dow, J Litchfield, ... Current Topics in Medicinal Chemistry 13 (7), 857-866, 2013 | 54 | 2013 |
| 4-aminopyrrolo [2, 3-d] pyrimidines as tyrosine kinase inhibitors RL Dow, K Koch US Patent 5,639,757, 1997 | 53 | 1997 |
| Genetic and Pharmacological Analyses of Involvement of Src-family, Syk and Btk Tyrosine Kinases in Platelet Shape Change M Bauer, P Maschberger, L Quek, SJ Briddon, D Dash, M Weiss, ... Thrombosis and haemostasis 85 (02), 331-340, 2001 | 51 | 2001 |
| β-adrenergic agonists RL Dow, KM Lundy US Patent 5,859,044, 1999 | 51 | 1999 |
| New bicyclic cannabinoid receptor-1 (CB1-R) antagonists PA Carpino, DA Griffith, S Sakya, RL Dow, SC Black, JR Hadcock, ... Bioorganic & medicinal chemistry letters 16 (3), 731-736, 2006 | 49 | 2006 |
James M TakacsUniversity of Nebraska-Lincolnبريد إلكتروني تم التحقق منه على unl.edu
