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Giuseppina De Simone
Giuseppina De Simone
Dirigente di Ricerca - Istituto di Biostrutture e Bioimmagini-CNR
Verified email at unina.it
Title
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Cited by
Year
Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms?
V Alterio, A Di Fiore, K D’Ambrosio, CT Supuran, G De Simone
Chemical reviews 112 (8), 4421-4468, 2012
12482012
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX
V Alterio, M Hilvo, A Di Fiore, CT Supuran, P Pan, S Parkkila, A Scaloni, ...
Proceedings of the National Academy of Sciences 106 (38), 16233-16238, 2009
5612009
Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation
G Canettieri, L Di Marcotullio, A Greco, S Coni, L Antonucci, P Infante, ...
Nature cell biology 12 (2), 132-142, 2010
3812010
Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes
M Hilvo, L Baranauskiene, AM Salzano, A Scaloni, D Matulis, A Innocenti, ...
Journal of Biological Chemistry 283 (41), 27799-27809, 2008
3722008
Anticancer carbonic anhydrase inhibitors: a patent review (2008–2013)
SM Monti, CT Supuran, G De Simone
Expert opinion on therapeutic patents 23 (6), 737-749, 2013
2722013
Benefits of sustained moderate weight loss
F Pasanisi, F Contaldo, G De Simone, M Mancini
Nutr Metab Cardiovasc Dis 11, 401-406, 2001
2692001
Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target
G De Simone, CT Supuran
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1804 (2), 404-409, 2010
2592010
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies
G De Simone, A Di Fiore, V Menchise, C Pedone, J Antel, A Casini, ...
Bioorganic & medicinal chemistry letters 15 (9), 2315-2320, 2005
259*2005
Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors
G De Simone, V Alterio, CT Supuran
Expert opinion on drug discovery 8 (7), 793-810, 2013
2582013
Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX
V Alterio, RM Vitale, SM Monti, C Pedone, A Scozzafava, A Cecchi, ...
Journal of the American Chemical Society 128 (25), 8329-8335, 2006
2402006
Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: three for the price of one
CT Supuran, V Alterio, A Di Fiore, K D’Ambrosio, F Carta, SM Monti, ...
Medicinal Research Reviews 38 (6), 1799-1836, 2018
2392018
Insights into peptide nucleic acid (PNA) structural features: The crystal structure of a d-lysine-based chiral PNA–DNA duplex
V Menchise, G De Simone, T Tedeschi, R Corradini, S Sforza, R Marchelli, ...
Proceedings of the National Academy of Sciences 100 (21), 12021-12026, 2003
2032003
Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity
CT Supuran, AD Fiore, GD Simone
Expert opinion on emerging drugs 13 (2), 383-392, 2008
1952008
(In) organic anions as carbonic anhydrase inhibitors
G De Simone, CT Supuran
Journal of Inorganic Biochemistry 111, 117-129, 2012
1932012
Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs?
GD Simone, AD Fiore, CT Supuran
Current Pharmaceutical Design 14 (7), 655-660, 2008
1882008
Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeantá…
V Menchise, G De Simone, V Alterio, A Di Fiore, C Pedone, A Scozzafava, ...
Journal of medicinal chemistry 48 (18), 5721-5727, 2005
1882005
The crystal structure of a hyper-thermophilic carboxylesterase from the archaeon Archaeoglobus fulgidus
G De Simone, V Menchise, G Manco, L Mandrich, N Sorrentino, D Lang, ...
Journal of Molecular Biology 314 (3), 507-518, 2001
1782001
A snapshot of a transition state analogue of a novel thermophilic esterase belonging to the subfamily of mammalian hormone-sensitive lipase
G De Simone, S Galdiero, G Manco, D Lang, M Rossi, C Pedone
Journal of Molecular Biology 303 (5), 761-771, 2000
1642000
The zinc coordination pattern in the η-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic families
G De Simone, A Di Fiore, C Capasso, CT Supuran
Bioorganic & medicinal chemistry letters 25 (7), 1385-1389, 2015
1352015
Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII
OO Guler, GD Simone, CT Supuran
Current medicinal chemistry 17 (15), 1516-1526, 2010
1322010
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